Nanoencapsulation of ultra-small superparamagnetic particles of iron oxide into human serum albumin nanoparticles

• Matthias G. Wacker,
• Mahmut Altinok,
• Stephan Urfels and
• Johann Bauer

Beilstein J. Nanotechnol. 2014, 5, 2259–2266, doi:10.3762/bjnano.5.235

• particles of iron oxide (USPIO) are used as contrast agents in magnetic resonance imaging, their encapsulation into the protein matrix enables the synthesis of diagnostic and theranostic agents by surface modification and co-encapsulation of active pharmaceutical ingredients. The present investigation deals

• with the surface modification and nanoencapsulation of USPIO into an albumin matrix by using ethanolic desolvation. Particles of narrow size distribution and with a defined particle structure have been achieved. Keywords: diagnostics; HSA; nanoencapsulation; nanoparticles; USPIO; Introduction Over

• the present study, nanoparticles consisting of HSA were formed by ethanolic desolvation [9]. These nanocarriers were used matrix system for the encapsulation of USPIO. USPIO have been efficiently applied as contrast agents for magnetic resonance imaging and allow the tracking of nanoparticles in vivo