Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• Sciences, Phenikaa University, Hanoi 12116, Vietnam 10.3762/bjnano.15.7 Abstract Hydrophobic berberine powder (BBR) and hydrophilic BBR nanoparticles (BBR NPs) were loaded into an electrospun polylactic acid (PLA) nanofiber scaffold for modulating the release behavior of BBR in an aqueous medium. The BBR

• systems, and tissue engineering, according to the requirement of BBR concentration for the desired therapeutic effects. Keywords: antibacterial activity; berberine; drug-release system; electrospun nanofiber; polylactic acid; Introduction Medicinal plants have various biologically active compounds, such

• as phenolic acids, alkaloids, saponins, coumarins, flavonoids, terpenoids, and carotenoids with great therapeutic effects [1]. Berberine (BBR) is a quaternary isoquinoline alkaloid, extracted from different medicinal plants, such as Coptis chinensis and Berberis vulgaris [2], and used in the

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• liposomes: 20–100 nm and large liposomes: >100 nm) are capable of loading both hydrophilic and lipophilic drugs [82][83]. Leishmanial drugs, such as miltefosine [84], buparvaquone [85], nitazoxanide [86], artemisinin [75], berberine [87], and paromomycin [88] have already been successfully loaded into

Antibacterial activity of a berberine nanoformulation

• Hue Thi Nguyen,
• Tuyet Nhung Pham,
• Anh-Tuan Le,
• Nguyen Thanh Thuy,
• Tran Quang Huy and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2022, 13, 641–652, doi:10.3762/bjnano.13.56

• the preparation of berberine (BBR) in nanoformulation to enhance its solubility and increase its antibacterial effectiveness against hospital-acquired infections. BBR nanoparticles (BBR NPs) were formed by antisolvent precipitation (ASP) using glycerol as a safe organic solvent. UV–vis absorption

• bacterial cells and severely damaged the cell walls. Therefore, BBR NPs prepared by ASP appear to be a potential candidate for the treatment of bacterial pathogens. Keywords: antibacterial activity; antisolvent precipitation (ASP); berberine nanoparticles (BBR NPs); glycerol; solubility; Introduction

• Phytochemicals are organic substances produced by plants with pharmacological and biological activity. Phytochemical-based medicines have become popular in the pharmaceutical market because of their diversity, availability, low cost, and little or no undesirable side effects [1]. Berberine (BBR) has been widely

Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure

• Giovanni N. Roviello,
• Domenica Musumeci,
• Valentina Roviello,
• Marina Pirtskhalava,
• Alexander Egoyan and
• Merab Mirtskhulava

Beilstein J. Nanotechnol. 2015, 6, 1338–1347, doi:10.3762/bjnano.6.138

• in the field of the development of novel anticancer drugs, we report a description of different classes of molecules characterized by their ability to interact with poly(rA). Some of them are of natural origin, as in the case of neomycin, palmatine, berberine, chelerythrine and other alkaloids and

• berberine, palmatine, coralyne and sanguinarine (Figure 3). The binding process involving these molecules, whose structures bring positive charges, is characterized predominantly by electrostatic interactions with the RNA, and in some cases by intercalative binding. The first report on the interaction of a

• isoquinoline compound with poly(rA) concerned berberine [24]. In particular, this alkaloid was found to bind poly(rA) with greater affinity than double-stranded B-DNA or tRNA [24]. Recently, the ability of berberine to interact with single-stranded poly(rA) was the object of another investigation presented by