Beilstein J. Nanotechnol.2014,5, 1380–1392, doi:10.3762/bjnano.5.151
interface in general.
Keywords: biobarrier; gastrointestinal tract; high-throughput profiling; nanomedicine; nanotoxicity; Introduction
Besides the wide use of nanomaterials in industrial products, biomedical applications of nanoparticles (NP) are steadily increasing [1][2][3][4][5]. However, despite
biomedical application as contrast agents or drug delivery devices [9][10]. From our experience in pharmaceutical and medical history, we have learned that oral delivery is the preferred administration route for patients [9][10]. Similar to the lung, also the GI tract is a major biobarrier target organ for
MTT assay (Figure 6). Similar to the lung surfactant [32], also epithelial cell of the GI tract are covered by an additional biobarrier, i.e., by mucous matrices [33]. To investigate the impact of mucus associated to GI tract cells on the observed effects, we included the mucus-secreting colorectal
PDF
Figure 1:
Transmission electron microscopy (TEM) images of representative ASP used in the study. Scale bar = ...