Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management

• Uzma Azeem Awan,
• Abida Raza,
• Shaukat Ali,
• Rida Fatima Saeed and
• Nosheen Akhtar

Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24

• properties such as significant absorption or scattering in the visible and near-infrared (NIR) regions, tunable aspect ratio, biocompatibility, fluorescence properties, and the ease of biofunctionalization, which makes them ideal in biomedical applications [13]. Gold-based nanomaterials (i.e., nanospheres

• , nanorods, nanoshells, and nanocages) have great potential in photothermal cancer therapy due to plasmonic properties and the ease of biofunctionalization. Gold nanorods (GNRs) are more preferable than other gold nanomaterials because of their photothermal conversion efficiency. Better nanotherapeutics can

Molecular architectonics of DNA for functional nanoarchitectures

• Debasis Ghosh,
• Lakshmi P. Datta and
• Thimmaiah Govindaraju

Beilstein J. Nanotechnol. 2020, 11, 124–140, doi:10.3762/bjnano.11.11

• the edges can be covalently modified with several active functionalities or biomolecules. The groups of Shangguan and Tan reported on the biofunctionalization of metal nanoparticles using aptamer-appended DNA tetrahedron nanostructures [68]. The aptamer-appended tetrahedron structures were constructed

Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents

• Natalia E. Gervits,
• Andrey A. Gippius,
• Alexey V. Tkachev,
• Evgeniy I. Demikhov,
• Sergey S. Starchikov,
• Igor S. Lyubutin,
• Alexander L. Vasiliev,
• Vladimir P. Chekhonin,
• Maxim A. Abakumov,
• Alevtina S. Semkina and
• Alexander G. Mazhuga

Beilstein J. Nanotechnol. 2019, 10, 1964–1972, doi:10.3762/bjnano.10.193

• and human serum albumin coated iron oxide nanoparticles was observed by Mössbauer spectroscopy. Conclusion: This difference in magnetic behavior is explained by the influence of biofunctionalization on the magnetic and electronic properties of the iron oxide nanoparticles. The ZF-NMR spectra analysis

Experimental study of an evanescent-field biosensor based on 1D photonic bandgap structures

• Jad Sabek,
• Francisco Javier Díaz-Fernández,
• Luis Torrijos-Morán,
• Zeneida Díaz-Betancor,
• Ángel Maquieira,
• María-José Bañuls,
• Elena Pinilla-Cienfuegos and
• Jaime García-Rupérez

Beilstein J. Nanotechnol. 2019, 10, 967–974, doi:10.3762/bjnano.10.97

• , biofunctionalization is a key step for providing a label-free biosensing device able to analyze a chemical or a biological sample without requiring any pre-treatment (as for example labeling). Since the operation of photonic biosensors based on evanescent waves relies on the interaction between the target analytes and

• biofunctionalization procedures that allow one to obtain biorecognition layers being as thin as possible and with robust links to the surface. This can be achieved, for example, by using covalent biofunctionalization strategies [8]. In this paper, we report the experimental work carried out to characterize and enhance

• into account, the PBG structures have been biofunctionalized using a light-assisted biofunctionalization protocol allowing for the covalent immobilization of half-antibodies, so that the thickness of the biorecognition layer can be significantly reduced. This biofunctionalization process was already

A biofunctionalizable ink platform composed of catechol-modified chitosan and reduced graphene oxide/platinum nanocomposite

• Peter Sobolewski,
• Agata Goszczyńska,
• Małgorzata Aleksandrzak,
• Karolina Urbaś,
• Joanna Derkowska,
• Agnieszka Bartoszewska,
• Jacek Podolski,
• Ewa Mijowska and
• Mirosława El Fray

Beilstein J. Nanotechnol. 2017, 8, 1508–1514, doi:10.3762/bjnano.8.151

• printing, it may be necessary to reduce the viscosity, in order to increase the Z value and reduce ligament length, for example by reducing the concentration of CHI-HCA polymer. Ink biofunctionalization and confocal imaging The biorecognition interface of any biosensor plays a crucial role, as it is the

• the catechol-modified chitosan matrix (Figure 4B). Chitosan/DNA interactions are largely driven by electrostatic interaction and, as a result, solution pH value, degree of deacetylation and molecular weight all play important roles [18]. Following biofunctionalization via glutaraldehyde linker to the

• , importantly, that the printed structures resist washing following biofunctionalization and hybridization, thanks to the adhesive properties of the catechol moiety. Our proof of concept involving DNA oligonucleotide probes demonstrates that the printed structures can be functionalized in a way that preserves

Comparison of four methods for the biofunctionalization of gold nanorods by the introduction of sulfhydryl groups to antibodies

• Xuefeng Wang,
• Zhong Mei,
• Yanyan Wang and
• Liang Tang

Beilstein J. Nanotechnol. 2017, 8, 372–380, doi:10.3762/bjnano.8.39

• GNR biofunctionalization and can be easily extended to other sensing applications based on other gold nanostructures or new biomolecules. Keywords: biofunctionalization; biosensing; four methods; gold nanorod; introduction of sulfhydryl groups; Introduction Gold nanorods (GNRs) are widely used in

• methods for the biofunctionalization of GNRs through the introduction of sulfhydryl groups to antibodies by using Traut’s reagent, DTT, PEG6-CONHNH2, and SH-PEG-NH2. We compared the sensitivity and specificity to detection of human IgG targets of four thiolated antibodies by using a functionalized-GNR

• GNR biofunctionalization developed in this work. They can be extended to other Au nanostructures (e.g., spheres, cages) to develop new protein-based applications for biosensors and multiplexed biosensing by immobilization of different-sized nanorods. Experimental Materials Hydrogen tetrachloroaurate

Comparison of four functionalization methods of gold nanoparticles for enhancing the enzyme-linked immunosorbent assay (ELISA)

• Paula Ciaurriz,
• Fátima Fernández,
• Edurne Tellechea,
• Jose F. Moran and
• Aaron C. Asensio

Beilstein J. Nanotechnol. 2017, 8, 244–253, doi:10.3762/bjnano.8.27

• biofunctionalization strategies with covalent and directional/adsorption: comparison by ELISA As described above, we decided to evaluate two other new approaches (Figure 1c,d). One approach is covalent conjugation, where antibodies and HRP are covalently bound to the surface by the means of a PEG linker through its

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

• Alexandra M. Greiner,
• Adria Sales,
• Hao Chen,
• Sarah A. Biela,
• Dieter Kaufmann and
• Ralf Kemkemer

Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155

• techniques that have been used for the fabrication of appropriate substrates for in vitro studies with vascular cells. We give a brief overview over possible surface structure geometries, mention compounds and methods for surface biofunctionalization and present the importance of the mechanical

Electrochemical coating of dental implants with anodic porous titania for enhanced osteointegration

• Amirreza Shayganpour,
• Alberto Rebaudi,
• Pierpaolo Cortella,
• Alberto Diaspro and
• Marco Salerno

Beilstein J. Nanotechnol. 2015, 6, 2183–2192, doi:10.3762/bjnano.6.224

• of the fabricated APT coating with phosphate ions occurs spontaneously, which can be already considered as a biofunctionalization of the nanoporous surface. Further in situ functionalization aiming at improved bioactivity of the nanoporous surfaces may be obtained by using additive species in the

Nanobioarchitectures based on chlorophyll photopigment, artificial lipid bilayers and carbon nanotubes

• Marcela Elisabeta Barbinta-Patrascu,
• Stefan Marian Iordache,
• Ana Maria Iordache,
• Nicoleta Badea and
• Camelia Ungureanu

Beilstein J. Nanotechnol. 2014, 5, 2316–2325, doi:10.3762/bjnano.5.240

• carbon nanotubes [18]. Bianco et al. [19] showed that carbon nanotube biofunctionalization lead not only to the improved solubility and biocompatibility of CNTs, but also transformed them into platforms for biomedical applications. Carbon nanotubes are generally considered biocompatible and of low

Influence of the PDMS substrate stiffness on the adhesion of Acanthamoeba castellanii

• Sören B. Gutekunst,
• Carsten Grabosch,
• Alexander Kovalev,
• Stanislav N. Gorb and
• Christine Selhuber-Unkel

Beilstein J. Nanotechnol. 2014, 5, 1393–1398, doi:10.3762/bjnano.5.152

• need for further biofunctionalization, as the PDMS was used in its hydrophobic, non-functionalized state. This is very important to note, as recently, indications have been found that not only the elasticity of the substrate is a decisive parameter for cell adhesion, but instead also the linkage of