Influence of calcium on ceramide-1-phosphate monolayers

• Joana S. L. Oliveira,
• Gerald Brezesinski,
• Alexandra Hill and
• Arne Gericke

Beilstein J. Nanotechnol. 2016, 7, 236–245, doi:10.3762/bjnano.7.22

• 10.3762/bjnano.7.22 Abstract Ceramide-1-phosphate (C1P) plays an important role in several biological processes, being identified as a key regulator of many protein functions. For instance, it acts as a mediator of inflammatory responses. The mediation of the inflammation process happens due to the

• the monolayer structure can be seen in the presence of a 150 times larger concentration of monovalent sodium ions. Therefore, calcium ions have clearly a strong affinity for the phosphomonoester of C1P. Keywords: calcium; ceramide-1-phosphate; Langmuir monolayers; phase behaviour; structural

• properties; Introduction Ceramide-1-phosphate (C1P) is a sphingoid analogue of phosphatidic acid, which has a sphingoid base with a phosphomonoester head group (Figure 1). It is synthesized in the trans-Golgi network (TGN), where ceramide is phosphorylated into C1P in a reaction catalyzed by a ceramide