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Search for "chemotherapeutics" in Full Text gives 12 result(s) in Beilstein Journal of Nanotechnology.
Ion beam processing of DNA origami nanostructures
Beilstein J. Nanotechnol. 2024, 15, 207–214, doi:10.3762/bjnano.15.20
- DNA origami nanostructures is rarely explored, yet promising applications are foreseen to require such information. DNA nanostructures have been explored as drug delivery vessels for chemotherapeutics [1][2]. With the constant pursuit of effective targeting strategies [3], they could eventually be
Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics
Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17
- particle [25][26]. PLGA is one of the finest materials for transporting chemotherapy drugs. PLGA transports not only hydrophobic but also hydrophilic drugs. The encapsulation of chemotherapeutics in PLGA nanoparticles has been extensively studied. PLGA has been loaded with doxorubicin, for instance, for
Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics
Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75
- , India Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India 10.3762/bjnano.14.75 Abstract Nanotechnology provides effective methods for precisely delivering chemotherapeutics to cancer cells, thereby improving efficacy and reducing off-target side effects. The targeted delivery
- of nanoscale chemotherapeutics is accomplished by two different approaches, namely the exploitation of leaky tumor vasculature (EPR effect) and the surface modification of nanoparticles (NPs) with various tumor-homing peptides, aptamers, oligonucleotides, and monoclonal antibodies (mAbs). Because of
- chemotherapeutics specifically to the targeted cancer cells. ACNPs combine the benefits of NPs and mAbs to provide high drug loads at the tumor site with better selectivity and delivery efficiency. The mAbs on the NP surfaces recognize their specific receptors expressed on the target cells and release the
Use of nanosystems to improve the anticancer effects of curcumin
Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78
- %) [2]. The most commonly used treatments involve chemotherapy, surgery, or a combination of both. Chemotherapy is based on the use of molecules such as doxorubicin, paclitaxel, cisplatin, and some proteins and peptides that induce cell death [3]. Conventional or low molecular weight chemotherapeutics
The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors
Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31
- toxicity and lack of efficacy (resistance). Nevertheless, the application of cytotoxic chemotherapeutics (e.g., daunorubicin and cytarabine), with or without HSCT, still remains the backbone of treatment for AML [6][7]. All chemotherapy agents interfere somehow with the DNA replication process or with cell
Rational design of block copolymer self-assemblies in photodynamic therapy
Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15
Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment
Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144
- Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development of drug delivery systems is important to
- : Docetaxel-loaded nanoparticles dispersed in a bioadhesive film were shown to be suitable for application of chemotherapeutics directly to the action site during surgical operation. The system was found to release chemotherapeutics for several days at the tumor site and neighboring tissue. This can be
- suggested to result in a more effective brain tumor treatment when compared to chemotherapeutics administered as an intravenous bolus infusion. Keywords: bioadhesive film; cationic nanoparticle; core–shell nanoparticle; docetaxel; glioma; Introduction A brain tumor is known as an abnormal growth of
Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation
Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132
- , Dresden 01171, Germany 10.3762/bjnano.8.132 Abstract We have previously shown that carbon nanofibers (CNFs) and carbon nanotubes (CNTs) can sensitize prostate cancer (PCa) cells to platinum-based chemotherapeutics. In order to further verify this concept and to avoid a bias, the present study
- investigates the chemosensitizing potential of CNFs and CNTs to the conventional chemotherapeutics docetaxel (DTX) and mitomycin C (MMC), which have different molecular structures and mechanisms of action than platinum-based chemotherapeutics. DU-145 PCa cells were treated with DTX and MMC alone or in
- contrast, the dose of platinum-based chemotherapeutics could only be reduced by up to 3-fold by combination with carbon nanomaterials. Furthermore, combinatory treatments with CNFs led mostly to an additive inhibition of short- and long-term proliferation compared to the individual treatments. Also, higher
Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles
Beilstein J. Nanotechnol. 2017, 8, 381–393, doi:10.3762/bjnano.8.40
- a tumour suppressor function for HTRA1. In various cancer types, an epigenetic silencing of HTRA1 has been observed. Moreover, a decreased HTRA1 expression is correlated both with a reduced response to chemotherapeutics and an augmented cell migration. Additionally, a reduced proliferation of tumour
Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels
Beilstein J. Nanotechnol. 2016, 7, 675–684, doi:10.3762/bjnano.7.60
- easily find them in, e.g., cosmetics [1], food additives [2], industrial process [3] and, especially, in medical therapy [4] and diagnostics [5]. In light of medical therapy, NPs have shown their extraordinary potential in cancer chemotherapeutics [6] and drug delivery systems [7], which successfully
Fulleropeptide esters as potential self-assembled antioxidants
Beilstein J. Nanotechnol. 2015, 6, 1065–1071, doi:10.3762/bjnano.6.107
- wide range of activities of fullerene–peptide conjugates has been studied [3][7][16]. Fulleropeptides synthesized by Prato's research group [17] showed a good bacteriostatic activity against Gram-positive bacterium S. aureus making it interesting for potential antimicrobial chemotherapeutics. Recently
Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer
Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107
- toxicity by incorporating mechanisms for targeted delivery of chemotherapeutics. Nanomedicine has become a viable solution for the specificity and toxicity problems with current chemotherapy treatment regimens [6][7][8][9]. Nanoparticles have facilitated tumor targeting and drug delivery in a variety of
- various chemotherapeutics [16][21][24]. Since the ND-DGEA+DOX system had superior efficacy and improved drug delivery, there may be a synergistic effect in using both the NDs and DGEA. Several researchers have confirmed that integrin targeting increases drug delivery and ultimately efficacy [38][39][40
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