Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan-Thang Cao,
• Vy Tran-Anh and
• Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

• of these systems to serve as medication and imaging agent carriers for cancer treatment and diagnostics, respectively. Keywords: cancer; chlorambucil; F127-folate; IR780; iron oxide nanoparticles; PLGA; theragnostics; Introduction Theragnostic nanoparticles (NPs) are a diagnostic and therapeutic

• diagnostics, near-infrared (NIR) fluorescent dyes are a potential alternative for the diagnosis and excision of residual malignant cancer, which is invisible by conventional visual examination and palpation [16][17][18]. Indocyanine green is the only NIR dye permitted for clinical use [19]. Dyes such as IR780

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• . Pronase was purchased from Roche diagnostics GmbH, Mannheim, Germany. Bovine hemoglobin (Actoheme®) was provided by Biophyll GmbH, Dietersburg, Germany. PHAGOTEST™ and PHAGOBURST™ test kits were purchased from Glycotope Biotechnology GmbH, Berlin, Germany. Mouse-derived monoclonal anti-human CD14 antibody

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• to detect analytes of interest in a wide range of applications such as diagnostics, environmental monitoring, and food quality measurements [1][2][3]. LFAs are well known for their simplicity, affordability, accessibility to patients, and ease of use [4]. Since the discovery of this technique in the

• application in photothermal LFA. Size-dependent photothermal properties Gold nanoparticles have benefits in the field of diagnostics because of their high absorption cross section, LSPR, ease of preparation, stability, and variable surface chemistry [48]. Most importantly, the high number of synthesis methods

• diagnostic technologies. With further refinement and advancements, GNC-based photothermal assays could revolutionize the field of point-of-care diagnostics and reliable disease detection. Recent studies have proven the applicability of multimodal LFAs for accurate and quantitative diagnosis. Yang et al

Microneedle patches – the future of drug delivery and vaccination?

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2023, 14, 494–495, doi:10.3762/bjnano.14.40

• diagnostics. Microneedles provide shallow transdermal access to the ISF and are an excellent match to these and other developments when integrated into arrays on a substrate to form a patch. The possibility of inexpensive mass-manufactured MN patches for drug delivery, vaccination, and diagnostic testing is a

• ][9]. Recent progress may be broadly categorised as MN design, fabrication, skin penetration studies, and applications, ranging from drug delivery and vaccination to diagnostics. The first two of these have received most attention, but considerable work is still to be done in all categories – more in

• vaccination and drug delivery, but there is growing evidence of future potential in diagnostics and even in plant science [11]. If the thematic issue helps to inform existing researchers and to encourage others to join them, as editors, we will meet our objectives, the ultimate goal being the acceptance and

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• care for patients with advanced NSCLC [13][14][15]. This review article briefly covers some of the advances in therapeutic protocols based on the novel discoveries in molecular profiles and mutational diagnostics of NSCLC, which harbor activating and resistance EGFR mutations along with corresponding

Concentration-dependent photothermal conversion efficiency of gold nanoparticles under near-infrared laser and broadband irradiation

• Vikas,
• Raj Kumar and
• Sanjeev Soni

Beilstein J. Nanotechnol. 2023, 14, 205–217, doi:10.3762/bjnano.14.20

• , therapeutics, and diagnostics [1][2][3][4][5]. The interaction of free electrons of gold nanoparticles with electromagnetic fields leads to oscillations of the electrons at plasmonic resonance frequencies. Nonradioactive decay of these oscillations causes the conversion of electromagnetic energy into heat [6

Microneedle-based ocular drug delivery systems – recent advances and challenges

• Piotr Gadziński,
• Anna Froelich,
• Monika Wojtyłko,
• Antoni Białek,
• Julia Krysztofiak and
• Tomasz Osmałek

Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98

• types and properties Microneedles applied for drug and vaccine delivery, as well as in diagnostics, can be classified according to several different criteria (Figure 1). The most common microneedle typifications are based on the geometry, the material applied to obtain the systems, the method of

• /). Microscopic image of the MNs obtained by Amer and Chen. Figure 6 was adapted from [178], M. Amer; R. K. Chen, "Hydrogel-Forming Microneedle Arrays for Sustained and Controlled Ocular Drug Delivery", Journal of Engineering and Science in Medical Diagnostics and Therapy, with permission from ASME. Copyright

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

Fabrication and testing of polymer microneedles for transdermal drug delivery

• Vahid Ebrahiminejad,
• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2022, 13, 629–640, doi:10.3762/bjnano.13.55

• considerable potential for medical applications such as transdermal drug delivery, point-of-care diagnostics, and vaccination. These miniature microdevices should successfully pierce the skin tissues while having enough stiffness to withstand the forces imposed by penetration. Developing low-cost and simple

• setting. Keywords: hot embossing; microneedles; penetration efficiency; thermoplastic polymers; two-photon polymerization; Introduction During the past two decades, MN devices have become a promising tool for transdermal drug delivery, vaccination, and point-of-care diagnostics [1][2]. MNs are a

• bacterial infections and medical emergencies, with point-of-care patch diagnostics replacing ponderous and expensive laboratory testing. Therefore, there is a growing interest in small patches incorporating mass manufacturable polymer MNs [4][5], with the point-of-care rapid diagnosis market alone predicted

Bacterial safety study of the production process of hemoglobin-based oxygen carriers

• Axel Steffen,
• Yu Xiong,
• Radostina Georgieva,
• Ulrich Kalus and
• Hans Bäumler

Beilstein J. Nanotechnol. 2022, 13, 114–126, doi:10.3762/bjnano.13.8

• (own cultivation) and Escherichia coli (ATCC 25922) were kindly provided by the Bereswill Lab, Institute of Microbiology, Infectious Diseases and Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany. Columbia agar with 5% of sheep blood was purchased from Thermo Fisher Diagnostics GmbH

Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

• Rouhollah Khodadust,
• Ozlem Unal and
• Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

• a fluorescence microscope. Considering the strong T2 signal of SPION@bPEI [35], these nanoparticles may be considered as dye-free dual-mode (MRI and optic) imaging agents. Such combinations are highly desired for diagnostics combined with intraoperative imaging, ex vivo analysis of nanoparticle

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• nanosystems. According to previous evidence, the use of nanosystems is highly flexible since it can be tailored for numerous applications with highly specific goals. Polymeric micelles and theranostics (a strategy that combines treatment and diagnostics) are two examples of such applications that are based on

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• expand the scope for delivery of vaccines and therapeutic agents through the skin and withdrawing biofluids for point-of-care diagnostics – so-called theranostics. Unskilled and painless applications of microneedle patches for blood collection or drug delivery are two of the advantages of microneedle

• microneedle systems applications, designs, material selection, and manufacturing methods. Keywords: drug delivery; microelectromechanical systems (MEMS); microfabrication; microneedles; point-of-care diagnostics; Introduction The concept of microneedle structures to penetrate painlessly the outermost layer

• channelling of the drug load to the active area [42]. It is likely that some increase in drug concentrations will be necessary, while applying multiple patches over time would mimic catheter infusions. Point-of-care diagnostics In addition to drug delivery, microneedles may be used for drawing blood or

A Au/CuNiCoS₄/p-Si photodiode: electrical and morphological characterization

• Adem Koçyiğit,
• Adem Sarılmaz,
• Teoman Öztürk,
• Faruk Ozel and
• Murat Yıldırım

Beilstein J. Nanotechnol. 2021, 12, 984–994, doi:10.3762/bjnano.12.74

• great attention due their unique electronic, magnetic, optical, and gas sensing properties. Spinel compounds can be employed in data storage applications, lithium-ion batteries, gas sensors, and medical diagnostics [1][2]. Spinels have a cubic crystal structure with the general chemical formula AB2X4

The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles

• Nabojit Das,
• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2021, 12, 924–938, doi:10.3762/bjnano.12.69

• variations and flexibility of tuning the size and shape of the metal nanoparticles at the nanoscale made them promising candidates for biomedical applications such as therapeutics, diagnostics, and drug delivery. However, safety and risk assessment of the nanomaterials for clinical purposes are yet to be

Fate and transformation of silver nanoparticles in different biological conditions

• Barbara Pem,
• Marija Ćurlin,
• Darija Domazet Jurašin,
• Valerije Vrček,
• Rinea Barbir,
• Vedran Micek,
• Raluca M. Fratila,
• Jesus M. de la Fuente and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2021, 12, 665–679, doi:10.3762/bjnano.12.53

• diagnostics (biosensing, bioimaging) [2][3]. Such prevalence has raised concerns among the regulatory authorities about the safety of AgNPs for humans due to significant lack of relevant regulatory data. Thus, the Scientific Committee on Consumer Safety (SCCS) highlighted in its final Opinion on Colloidal

On the stability of microwave-fabricated SERS substrates – chemical and morphological considerations

• Limin Wang,
• Aisha Adebola Womiloju,
• Christiane Höppener,
• Ulrich S. Schubert and
• Stephanie Hoeppener

Beilstein J. Nanotechnol. 2021, 12, 541–551, doi:10.3762/bjnano.12.44

• in chemical and bioanalytical research [1][2]. Its application in chemistry, biosensing, materials science, engineering, and medical diagnostics was successfully introduced and can provide valuable information [1][2][3][4]. Since it was discovered in 1974 by Fleischmann et al. that the intensity of

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• , Doha, Qatar 10.3762/bjnano.12.31 Abstract Nanomedicine has emerged as a novel cancer treatment and diagnostic modality, whose design constantly evolves towards increasing the safety and efficacy of the chemotherapeutic and diagnostic protocols. Molecular diagnostics, which create a great amount of

• therapy goals in myeloid leukemia. Hence, the design of the nanoscale carriers needs to integrate strategies for extravasation in the bone marrow niches and subsequent specific molecular recognition of the LSC. Current advances in molecular diagnostics offer a glimpse into the molecular profile of each

Free and partially encapsulated manganese ferrite nanoparticles in multiwall carbon nanotubes

• Saja Al-Khabouri,
• Salim Al-Harthi,
• Toru Maekawa,
• Mohamed E. Elzain,
• Ashraf Al-Hinai,
• Ahmed D. Al-Rawas,
• Abbsher M. Gismelseed,
• Ali A. Yousif and
• Myo Tay Zar Myint

Beilstein J. Nanotechnol. 2020, 11, 1891–1904, doi:10.3762/bjnano.11.170

• drawbacks, it has been suggested that encapsulating materials into the hollow regions of carbon nanotubes can result in a significant change of the properties of the inserted materials [1][2][3]. Manganese ferrite nanoparticles can be used in biomedical diagnostics and have good properties as contrast

Selective detection of complex gas mixtures using point contacts: concept, method and tools

• Alexander P. Pospelov,
• Victor I. Belan,
• Dmytro O. Harbuz,
• Volodymyr L. Vakula,
• Lyudmila V. Kamarchuk,
• Yuliya V. Volkova and
• Gennadii V. Kamarchuk

Beilstein J. Nanotechnol. 2020, 11, 1631–1643, doi:10.3762/bjnano.11.146

• –desorption processes on the active surface of the sensor are eventually reversible and are characterized by a significant hysteresis. This complex nature of the response unfolds broad prospects for identifying the specific metabolism of each patient. Therefore, using the sensor in medical diagnostics is an

Transient coating of γ-Fe₂O₃ nanoparticles with glutamate for its delivery to and removal from brain nerve terminals

• Konstantin Paliienko,
• Artem Pastukhov,
• Michal Babič,
• Daniel Horák,
• Olga Vasylchenko and
• Tatiana Borisova

Beilstein J. Nanotechnol. 2020, 11, 1381–1393, doi:10.3762/bjnano.11.122

• neurological disorders. Excessive ambient glutamate concentration is a characteristic feature of, among others, stroke, brain trauma, epilepsy, and seizure development. Superparamagnetic γ-Fe2O3 nanoparticles are very promising in targeted drug delivery, cancer therapy, diagnostics, and hyperthermia treatment

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• and dosages for the safe usage of SPIONs [26]. SPIONs have immense potential in diagnostics and treatment of various diseases, and also, in biotechnology and research. However, there is still a lack of understanding about how to synthesize SPIONs that are truly safe for human application and also for

• detection. SPIONs have gained a lot of interest in theranostics, which combines diagnostics and treatment by a single intervention, where they show a lot of promise [64][134][135][136][137][138]. Depending on the dimension of the SPIONs, the heating during hyperthermia is determined by Néel relaxation for

Gas-sensing features of nanostructured tellurium thin films

• Dumitru Tsiulyanu

Beilstein J. Nanotechnol. 2020, 11, 1010–1018, doi:10.3762/bjnano.11.85

• ] for extended reviews on the topic). In the last decade, Te has also become an attractive element with great biological applicability since it can be used as quantum dots in imaging and diagnostics and has antibiotic properties [3]. Even though Te has a biological relevance, it is largely used in the

Uniform Fe₃O₄/Gd₂O₃-DHCA nanocubes for dual-mode magnetic resonance imaging

• Miao Qin,
• Yueyou Peng,
• Mengjie Xu,
• Hui Yan,
• Yizhu Cheng,
• Xiumei Zhang,
• Di Huang,
• Weiyi Chen and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2020, 11, 1000–1009, doi:10.3762/bjnano.11.84

• -weighted images showed that FGDA nanocubes act as a dual-mode contrast agent enhancing MRI quality. Overall, these experimental results suggest that the FGDA nanocubes are interesting tools that can be used to increase MRI quality, enabling accurate clinical diagnostics. Keywords: 3,4

• diagnostics due to its high spatial resolution and capability to differentiate between healthy and unhealthy soft tissues [1][2][3][4][5]. However, due to the substantial increase in the number and complexity of diseases, and also to the fact that MRI has low sensitivity in the absence of contrast, many

Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

• compounds lies in their ability to target specific molecules and biological pathways, and thus, modulate molecular activities in a positive or negative manner [4]. The outstanding possibilities offered by the use of such molecules (proteins, peptides and nucleic acids) in the diagnostics and treatment of a