pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

• Karishma Berta Cotta,
• Sarika Mehra and
• Rajdip Bandyopadhyaya

Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84

• identical treatment conditions (Figure 6a). The increased uptake could be due to active engulfment of nanoparticles by macrophages, due to their larger size (20–120 nm size range) and surface charge (+29 mV or −16.5 mV) [46], which results in simultaneous internalization of larger amounts of drug. Figure 6b

On the pathway of cellular uptake: new insight into the interaction between the cell membrane and very small nanoparticles

• Claudia Messerschmidt,
• Daniel Hofmann,
• Anja Kroeger,
• Katharina Landfester,
• Volker Mailänder and
• Ingo Lieberwirth

Beilstein J. Nanotechnol. 2016, 7, 1296–1311, doi:10.3762/bjnano.7.121

• suspension was added to the cell culture medium, yielding the final concentration for exposure. For transmission electron microscopy and for cytotoxicity assays, cells were incubated with SiNPs for 10 min to 24 h at 37 °C and 5% CO2 before further processing. To check if the observed particle engulfment is

Silica-coated upconversion lanthanide nanoparticles: The effect of crystal design on morphology, structure and optical properties

• Uliana Kostiv,
• Miroslav Šlouf,
• Hana Macková,
• Alexander Zhigunov,
• Hana Engstová,
• Katarína Smolková,
• Petr Ježek and
• Daniel Horák

Beilstein J. Nanotechnol. 2015, 6, 2290–2299, doi:10.3762/bjnano.6.235

• specific application. Thus, various ligands and functionalities have to be attached to the particle surface to provide efficient drug delivery, to ensure engulfment by the cells, or to control the release of biomolecules and their specific target. Finally, the surface modification must ensure that the

Intake of silica nanoparticles by giant lipid vesicles: influence of particle size and thermodynamic membrane state

• Florian G. Strobl,
• Florian Seitz,
• Christoph Westerhausen,
• Armin Reller,
• Adriano A. Torrano,
• Christoph Bräuchle,
• Achim Wixforth and
• Matthias F. Schneider

Beilstein J. Nanotechnol. 2014, 5, 2468–2478, doi:10.3762/bjnano.5.256

• of nanoparticles into cells often involves their engulfment by the plasma membrane and a fission of the latter. Understanding the physical mechanisms underlying these uptake processes may be achieved by the investigation of simple model systems that can be compared to theoretical models. Here, we

• models and indicate that these models have to be extended in order to capture the interaction between nanomaterials and biological membranes correctly. Keywords: cells; endocytosis; engulfment; fission; gel phase; giant unilamellar lipid vesicles (GUV); lipid membranes; liquid phase; nanoparticle

• . Especially the dependence of the uptake efficiency on the particle size is still an important topic [11][12]. Usually, a complex cell machinery is involved in endocytosis. However, particle uptake including the engulfment by the membrane has also been reported for red blood cells, which are known for not