Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• ]. For decades, science has been trying to overcome these problems [6]. Although erythrocytes also pose as a CO2 transporter and native hemoglobin as a buffer system [7], research is being focused on their function as oxygen transporters. The search is on for a laboratory-produced oxygen carrier that is

• retention time of oxygen carriers in the circulatory system. Erythrocytes and the Hb they contain have a mean survival time of about 120 days within the human body [7]. HBOCs, in contrast, have been eliminated within minutes to a few hours in previous experiments [5][23]. Much of this process appears to

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• -VEHICLE and NLC-BNZ, the latter exhibiting a higher HA, could be explained by adding the HA of the free drug to the effect of the vehicle on erythrocytes. More studies would be necessary to investigate the effect of the composition, size, or porosity of these nanoparticles after a long term exposure to

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• membranes, provides a new approach to address NP deficiencies [9]. The encapsulation of NPs with cell membranes can endow the NPs with biomimetic functions and replicate the biological characteristics derived from the original cells, such as the immune evasion of erythrocytes [10] and platelets [11] and the

• membranes have been exploited for the development of novel membrane NP-based therapies, such as erythrocytes [10], platelets [11], cancer cells [14], stem cells [12], immune cells [13], central nervous system-derived cells [17], bacterial outer membrane vesicles [18], and extracellular vesicles [19]. Cancer

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• and high biocompatibility. SPIONs are metabolized in the lysosomes into a soluble non-superparamagnetic form or iron. Then, iron ions join the iron pool in the blood and can be incorporated by erythrocytes as part of hemoglobin [21][183]. However, the concern about serious anaphylactic reactions, the

Understanding nanoparticle flow with a new in vitro experimental and computational approach using hydrogel channels

• Armel Boutchuen,
• Dell Zimmerman,
• Abdollah Arabshahi,
• John Melnyczuk and
• Soubantika Palchoudhury

Beilstein J. Nanotechnol. 2020, 11, 296–309, doi:10.3762/bjnano.11.22

• Newtonian. Particle–particle interactions between erythrocytes and NPs and ligand–receptor binding have not been considered in this model as we first wanted to understand the flow of NPs through soft, biomimetic channels. In addition, particles that came in contact with the wall were assumed to be deposited

Facile biogenic fabrication of hydroxyapatite nanorods using cuttlefish bone and their bactericidal and biocompatibility study

• Satheeshkumar Balu,
• Manisha Vidyavathy Sundaradoss,
• Swetha Andra and
• Jaison Jeevanandam

Beilstein J. Nanotechnol. 2020, 11, 285–295, doi:10.3762/bjnano.11.21

• and Materials standard F756-00. Generally, the addition of hydroxyapatite microcrystals with blood will lead to hemolysis via aggregation of erythrocytes and membrane damage induced by crystals [49]. Moreover, Wiessner et al. (1988) showed that the crystallinity of the Hap plays a crucial role in

Non-agglomerated silicon–organic nanoparticles and their nanocomplexes with oligonucleotides: synthesis and properties

• Asya S. Levina,
• Marina N. Repkova,
• Nadezhda V. Shikina,
• Zinfer R. Ismagilov,
• Svetlana A. Yashnik,
• Dmitrii V. Semenov,
• Yulia I. Savinovskaya,
• Natalia A. Mazurkova,
• Inna A. Pyshnaya and
• Valentina F. Zarytova

Beilstein J. Nanotechnol. 2018, 9, 2516–2525, doi:10.3762/bjnano.9.234

• -glutamine (Sigma-Aldrich, USA); RPMI-1640 medium; antibiotics (BioloT, Russia); fetal calf serum (Gibco, USA). Сhicken erythrocytes, MDCK cells, and influenza A virus strain A/chicken/Kurgan/05/2005 (H5N1) were from FBRI Vector, Russia. Trypsin (1 mg/mL) and penicillin-streptomycin (100 U/mL) were stored at

• the virus titer. The presence of the virus was visually determined under a microscope by the cytopathic action and in the hemagglutination reaction with a 1% suspension of chicken erythrocytes. The virus titer was expressed in terms of log TCID50/mL (Figure 6). The titer was evaluated by noting the

Evaluation of quantum dot conjugated antibodies for immunofluorescent labelling of cellular targets

• Jennifer E. Francis,
• David Mason and
• Raphaël Lévy

Beilstein J. Nanotechnol. 2017, 8, 1238–1249, doi:10.3762/bjnano.8.125

• fibrillary acidic proteins (GFAPs) [12], mortalin [23], erythrocytes [24], GRP78 protein [25], caveolin-1 [26], golgi [20], and nuclear HER2 targets [6]. The majority of this labelling, however, was done with in-house synthesised Qdots rather than commercially available Qdots [27]. The use of commercially

High antiviral effect of TiO₂·PL–DNA nanocomposites targeted to conservative regions of (−)RNA and (+)RNA of influenza A virus in cell culture

• Asya S. Levina,
• Marina N. Repkova,
• Elena V. Bessudnova,
• Ekaterina I. Filippova,
• Natalia A. Mazurkova and
• Valentina F. Zarytova

Beilstein J. Nanotechnol. 2016, 7, 1166–1173, doi:10.3762/bjnano.7.108

• : RPMI-1640 medium; antibiotics (BioloT, Russia); trypsin, L-glutamine; PBS buffer (Sigma, USA); and fetal calf serum (Gibco, USA). TiO2 nanoparticles were synthesized in the crystal form (anatase) as described in [17]. Сhicken erythrocytes, MDCK cells, and influenza A virus strains Aichi/2/68 (H3N2), A

• visually determined under a microscope by the cytopathic action and in the hemagglutination reaction with a 1% suspension of chicken erythrocytes. The virus titer was expressed in terms of TCID50/mL or log TCID50/mL (Table 2 and Figure 2, respectively). The titer was evaluated by noting the highest

Fabrication of hybrid graphene oxide/polyelectrolyte capsules by means of layer-by-layer assembly on erythrocyte cell templates

• Joseba Irigoyen,
• Nikolaos Politakos,
• Eleftheria Diamanti,
• Elena Rojas,
• Marco Marradi,
• Raquel Ledezma,
• Layza Arizmendi,
• J. Alberto Rodríguez,
• Ronald F. Ziolo and
• Sergio E. Moya

Beilstein J. Nanotechnol. 2015, 6, 2310–2318, doi:10.3762/bjnano.6.237

• FTIR spectroscopies. Keywords: capsules; erythrocytes; graphene; layer by layer; polyelectrolyte membranes; Introduction The past decades have witnessed explosive growth in research on low-dimensional carbon forms with graphene and carbon nanotubes in the forefront [1][2][3]. The unique electrical

• top of the erythrocytes, 3D closed films containing walls of PE/GO and an empty volume can be produced. Capsules based on GO can have applications in drug delivery, especially for topical applications, as the LbL capsules provide low degradability and high stability through the GO. The use of GO in

• and show the prominent (002) peak at 12.0 degrees 2θ, indicating an inter-planar GO sheet distance of 0.737 nm [29]. Prominent FTIR bands for GO were observed at 3415, 1723, 1623, 1394 and 1050 cm−1 as reported in [30]. A scheme of the layer-by-layer assembly applied on the erythrocytes for the

Protein corona – from molecular adsorption to physiological complexity

• Lennart Treuel,
• Dominic Docter,
• Michael Maskos and
• Roland H. Stauber

Beilstein J. Nanotechnol. 2015, 6, 857–873, doi:10.3762/bjnano.6.88

• experiments by using primary human cell models of the blood system. Pristine NPs immediately affected the vitality of endothelial cells, triggered thrombocyte activation and aggregation, and resulted in hemolysis of erythrocytes. However, such pristine NPs existed only for a very brief period of time in the

Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation

• Ivonne Brüstle,
• Thomas Simmet,
• Gerd Ulrich Nienhaus,
• Katharina Landfester and
• Volker Mailänder

Beilstein J. Nanotechnol. 2015, 6, 383–395, doi:10.3762/bjnano.6.38

• assume that this is due to an increase of free intracellular iron ions but obviously also depends on the cell type. For hHSCs and hMSCs, lineage differentiation into erythrocytes, granulocytes, and megakaryocytes or adipocytes, osteocytes and chondrocytes, was not influenced by the particles when

Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

• Anja Ostrowski,
• Daniel Nordmeyer,
• Alexander Boreham,
• Cornelia Holzhausen,
• Lars Mundhenk,
• Christina Graf,
• Martina C. Meinke,
• Annika Vogt,
• Sabrina Hadam,
• Jürgen Lademann,
• Eckart Rühl,
• Ulrike Alexiev and
• Achim D. Gruber

Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25

• pink cells with finely stippled cytoplasm whereas erythrocytes within sinusoids can be identified by their intensely pink color. Autoradiographic detection of radiolabeled dPG35S amine in organs and tissues. (a) Semiquantitative micro imager analysis detected different amounts of dPG35S amine in mouse

Distinction of nucleobases – a tip-enhanced Raman approach

• Regina Treffer,
• Xiumei Lin,
• Elena Bailo,
• Tanja Deckert-Gaudig and
• Volker Deckert

Beilstein J. Nanotechnol. 2011, 2, 628–637, doi:10.3762/bjnano.2.66

• virus investigation [10] and studies of bacterial [11] and cellular systems [12][13], as well as of erythrocytes [14]. The first TERS experiments on DNA base nanocrystals [15][16][17] and a study of the hydrogen bonding between adenine and thymine on a gold substrate [18] showed that a distinction of