Optical techniques for cervical neoplasia detection

• Tatiana Novikova

Beilstein J. Nanotechnol. 2017, 8, 1844–1862, doi:10.3762/bjnano.8.186

• 70% and specificity of 80% in detecting neoplastic areas, when using histopathology analysis as gold-standard diagnosis. Lower average sensitivity compared to conventional colposcopy performance was attributed to the fact that during the patient-based colposcopy analysis a delimitation of abnormal

Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

• Anja Ostrowski,
• Daniel Nordmeyer,
• Alexander Boreham,
• Cornelia Holzhausen,
• Lars Mundhenk,
• Christina Graf,
• Martina C. Meinke,
• Annika Vogt,
• Sabrina Hadam,
• Jürgen Lademann,
• Eckart Rühl,
• Ulrike Alexiev and
• Achim D. Gruber

Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25

• these techniques should therefore respect their specific merits and limitations as no single approach combines all desired properties. Keywords: fluorescence lifetime imaging; fluorescence microscopy; histopathology; light microscopic autoradiography; structured illumination microscopy; Introduction

• developments of both hard- and software have further contributed to the advancement of FLIM [102] that seems to hold great potential for its use in a number of biomedical applications, for example, as diagnostic tool for histopathology [99]. Spectral imaging and linear unmixing Spectral imaging combined with

• suitability for toxicological evaluation in a larger tissue context. The advantages and disadvantages of each detection method must be weighed against each other with regard to the study goal, nature of particles to be detected, need for reliable histopathology, technical expertise and equipment available