pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

• Karishma Berta Cotta,
• Sarika Mehra and
• Rajdip Bandyopadhyaya

Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84

• -TB drugs against mycobacteria, which are found to be resistant to rifampicin and/or isoniazid, the first-line drugs [17]. Although at present, moxifloxacin, ofloxacin and levofloxacin are the major fluoroquinolones used in tuberculosis therapeutics [21], many clinical isolates of M. tuberculosis have

Perovskite-structured CaTiO₃ coupled with g-C₃N₄ as a heterojunction photocatalyst for organic pollutant degradation

• Ashish Kumar,
• Christian Schuerings,
• Suneel Kumar,
• Ajay Kumar and
• Venkata Krishnan

Beilstein J. Nanotechnol. 2018, 9, 671–685, doi:10.3762/bjnano.9.62

• of a wide band gap material with a low band gap material [30]. Natarajan et al. have demonstrated the enhanced degradation of isoniazid (a pharmaceutical pollutant) over the g-C3N4–TiO2 nanocomposite via a direct Z-scheme charge transfer mechanism [31]. The enhanced photocatalytic activity has been

Preparation of alginate–chitosan–cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds

• Albert Ivancic,
• Fliur Macaev,
• Fatma Aksakal,
• Veaceslav Boldescu,
• Serghei Pogrebnoi and
• Gheorghe Duca

Beilstein J. Nanotechnol. 2016, 7, 1208–1218, doi:10.3762/bjnano.7.112

• , 41400, Turkey 10.3762/bjnano.7.112 Abstract This paper describes the synthesis and application of alginate–chitosan–cyclodextrin micro- and nanoparticulate systems loaded with isoniazid (INH) and isoconazole nitrate (ISN) as antimycobacterial compounds. Preparation and morphology of the obtained

• density distribution. It has been detected that alginate–chitosan–cyclodextrin microparticulate systems loaded with INH and ISN are as effective as pure INH applied in higher dosages. Keywords: chitosan; β-cyclodextrin; density functional theory (DFT); isoconazole; isoniazid; molecular docking

• cell walls [17], disorganizing their double lipid layer and increasing their penetrability for active compounds [18]. We propose the preparation of chitosane–alginate–cyclodextrin particles containing the antimycobacterial compounds isoniazid (INH) and isoconazole nitrate (ISN). INH (4