Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• mechanisms involved in cancer, such as apoptotic proteins (e.g., Bcl-2 survival protein, tumour protein p53, tumour necrosis factor, and nuclear factor kappa-B) [23][24], cancer surface markers (CD44, CD133, and ALDH1) [25] signaling pathways (e.g., PI3K/AKT/mTOR pathway, Hippo pathway, Wnt/β-catenin pathway

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• pathway inhibitor/s EGFR signal transduction pathways can be roughly divided into a pro-survival arm with the PI3K-mTOR-AKT cascade and a proliferative arm with the Ras-Raf-Mek-Erk cascade. Enhanced kinase activity on mutated EGFR with exon 19 deletion is associated with upregulated c-MYC levels through

• several downstream effectors [75][76][77]. The binding of KRAS-GTP to several effectors, among them PIK3K and RAF kinases, triggers activation of downstream AKT and mTOR (PIK3K), which regulates apoptosis, metabolism, and translation, as well as MEK and ERK signaling (RAF kinases), which influences cell

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• proapoptotic effect through its interaction with multiple molecular targets, including caspases (3, 9, and 8), Apaf1, PARP, Bax, Cyto-C, PUMA, MCL-1, and Survivin, while also suppressing the expression of β-catenin, p-glycogen synthase kinase-3β (GSK-3β), cyclin D1, c-myc, and the PI3K/Akt/mTOR pathway [24

Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

• Cornelia Loos,
• Tatiana Syrovets,
• Anna Musyanovych,
• Volker Mailänder,
• Katharina Landfester,
• G. Ulrich Nienhaus and
• Thomas Simmet

Beilstein J. Nanotechnol. 2014, 5, 2403–2412, doi:10.3762/bjnano.5.250

• used superparamagnetic iron oxide nanoparticles. Keywords: amino groups; apoptosis; carboxyl groups; cell proliferation; leukemia cell lines; macrophages; mTOR; polystyrene nanoparticles; Review Applications of polystyrene Polystyrene, one of the most extensively used types of plastic [1], is an

• rapamycin (mTOR), a key kinase controlling cell growth and proliferation and implicated in many human diseases including cancer and diabetes [65]. Thus, the integrity of membranes of acidic lysosomal compartments are important for the activation of mTOR [65]. We could show that PS-NH2 inhibits, whereas PS

• -COOH activates the mTOR signaling in leukemia cells. Consistently, PS-NH2 inhibits the activation of the mTOR downstream targets, Akt and p70 ribosomal S6 kinase 1, and blocked proliferation in three leukemia cell lines in vitro and in vivo [41]. Conclusion In these studies, we have used functionalized