Nanolesions induced by heavy ions in human tissues: Experimental and theoretical studies

• Marcus Bleicher,
• Lucas Burigo,
• Marco Durante,
• Maren Herrlitz,
• Michael Krämer,
• Igor Mishustin,
• Iris Müller,
• Francesco Natale,
• Igor Pshenichnov,
• Stefan Schramm,
• Gisela Taucher-Scholz and
• Cathrin Wälzlein

Beilstein J. Nanotechnol. 2012, 3, 556–563, doi:10.3762/bjnano.3.64

• . Keywords: DNA repair; heavy ions; microdosimetry; Monte Carlo simulations; nanolesions; radiation-induced nanostructures; Introduction In a low-dose field of γ-rays, such as that normally experienced on Earth due to background radiation, each human cell is traversed by very few electrons, which hence

• less compact state (high GC content) could be a more favorable environment for γH2AX spreading than highly compact heterochromatin [14]. MCHIT simulations of microdosimetry distributions The Monte Carlo method is a convenient technique to account for the interactions of beam nuclei and all secondary

• . The energy ε delivered to the small sensitive volume in a single event fluctuates due to the stochastic nature of particle propagation in media. Microdosimetry measurements provide the probability distributions for lineal energy defined as y = ε/, where is the mean chord length of the sensitive