Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment

• Lester Uy Vinzons,
• Guo-Chung Dong and
• Shu-Ping Lin

Beilstein J. Nanotechnol. 2023, 14, 1157–1168, doi:10.3762/bjnano.14.96

• . However, few studies have investigated the impact of discrete nanostructures, such as nanopillars and nanoholes, and their combination with microgrooves on neurite outgrowth and alignment. Furthermore, numerous techniques have been developed for surface micro-/nanopatterning, but simple and low-cost

• approaches are quite limited. In this work, we show that nanopillars and nanoholes, and their combination with microgrooves, can be patterned on polyurethane (PU) films using a low-cost, reusable photoresist master mold prepared via nanosphere lens lithography and UV-LED photolithography, with specific

• axons. Also, Huang et al. [12] showed that microgrooves with scattered nanodots result in neurite elongation and alignment of spinal cord neurons as well as functional connection between spinal cord slices. Studies on the application of discrete nanostructures and multiscale structures on peripheral

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

An investigation on the drag reduction performance of bioinspired pipeline surfaces with transverse microgrooves

• Weili Liu,
• Hongjian Ni,
• Peng Wang and
• Yi Zhou

Beilstein J. Nanotechnol. 2020, 11, 24–40, doi:10.3762/bjnano.11.3

• Chemical and Petroleum Engineering, University of Calgary, Calgary T2N1N4, Canada 10.3762/bjnano.11.3 Abstract A novel surface morphology for pipelines using transverse microgrooves was proposed in order to reduce the pressure loss of fluid transport. Numerical simulation and experimental research efforts

• were undertaken to evaluate the drag reduction performance of these bionic pipelines. It was found that the vortex ‘cushioning’ and ‘driving’ effects produced by the vortexes in the microgrooves were the main reason for obtaining a drag reduction effect. The shear stress of the microgrooved surface was

• surface morphology of shark skin and bird feathers. In Figure 1a, it is evident that the surface of shark skin is rough and covered with microgrooves. Sharks are known to be one of the fastest fish in the ocean. The phenomenon of nonsmooth surfaces with low drag has attracted the attention of researchers

Silicon microgrooves for contact guidance of human aortic endothelial cells

• Sara Fernández-Castillejo,
• Pilar Formentín,
• Úrsula Catalán,
• Josep Pallarès,
• Lluís F. Marsal and
• Rosa Solà

Beilstein J. Nanotechnol. 2017, 8, 675–681, doi:10.3762/bjnano.8.72

• microscale features to mimic the endothelium in lineal vessels. Keywords: cell morphology; contact guidance; microgrooves; silicon; human aortic endothelial cells (HAECs); Introduction Micro- and nanostructured materials for medical devices have demonstrated that surface topography as well as surface

• images demonstrating the contact-guidance effect of the microgrooves on cells cultured on these substrates for 2 days. Cells cultured on flat silicon substrates exhibited a random orientation, while HAECs seeded onto grooved surfaces were elongated and aligned in the direction of the grooves. These

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

• Alexandra M. Greiner,
• Adria Sales,
• Hao Chen,
• Sarah A. Biela,
• Dieter Kaufmann and
• Ralf Kemkemer

Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155

• the feature geometry and size. Some studies reported that proliferation of SMCs was negatively affected by PDMS microgrooves [204][205] and titanium oxide (TiO2) nanotube surfaces [31]. However, nanopits positively regulated SMC proliferation and gene expression [30]. In other studies, human SMCs from

• microgrooved PDMS substrates an enhanced aspect ratio (cell length to width ratio) and a parallel alignment of the cell body with respect to the groove axis (Figure 4C) [21][24]. Rat-derived SMCs aligned stronger along the direction of microgrooves, the narrower these grooves were [21]. Moreover, cells also

• groove axis [21][24]. The fact that the nuclear shape is influenced by microstructures leads to the assumption that some changes in the genetic material could take place. It was revealed that changes in nuclear shape, non-invasively induced by microgrooves, caused reorganization of nuclear lamina and