Beilstein J. Nanotechnol.2016,7, 484–491, doi:10.3762/bjnano.7.42
microrheology is a valuable tool to determine viscoelastic properties of polymer networks. Observing the response of the beads to the excitation of a reference leads to dynamic and morphological information of the material. In this work we present an expansion of the well-known active two-point microrheology
ability of the network to transmit mechanical forces. We also take a closer look at the influence of noise on lock-in measurements and state some simple rules for improving the signal-to-noise ratio.
Keywords: cytoskeleton; intermediate filaments; lock-in technique; microrheology; optical tweezers
, this method is named passive microrheology [1][2][3][4]. The resulting shear modulus shows the elastic and diffusive behavior of the investigated medium over the frequency range accessible by the measuring setup. This output is the result of different methods handling the unilateral Laplace transform
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Figure 1:
Simulations of the accuracy of the lock-in method. The red line shows the ratio between expected os...