Comparative electron microscopy particle sizing of TiO₂ pigments: sample preparation and measurement

• Ralf Theissmann,
• Christopher Drury,
• Markus Rohe,
• Thomas Koch,
• Jochen Winkler and
• Petr Pikal

Beilstein J. Nanotechnol. 2024, 15, 317–332, doi:10.3762/bjnano.15.29

• multimodal and why the spICP-MS D50n ECD results are much higher than equivalent D50n ECD results obtained by EM. Additionally, and somewhat unexpectedly, there are nearly no particles larger than 500 nm detected in the hand-shaken sample. As a result, both instrumental limitations and fundamental

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• passive targeting and offer multimodal tumor therapy. In recent years, the use of nanotechnology-based cancer drugs has emerged as a promising alternative treatment approach. Utilizing various nanostructures as specific vehicles for drug delivery enhances efficacy and pharmacokinetic properties of

Measurements of dichroic bow-tie antenna arrays with integrated cold-electron bolometers using YBCO oscillators

• Leonid S. Revin,
• Dmitry A. Pimanov,
• Alexander V. Chiginev,
• Anton V. Blagodatkin,
• Viktor O. Zbrozhek,
• Andrey V. Samartsev,
• Anastasia N. Orlova,
• Dmitry V. Masterov,
• Alexey E. Parafin,
• Victoria Yu. Safonova,
• Anna V. Gordeeva,
• Andrey L. Pankratov,
• Leonid S. Kuzmin,
• Anatolie S. Sidorenko,
• Silvia Masi and
• Paolo de Bernardis

Beilstein J. Nanotechnol. 2024, 15, 26–36, doi:10.3762/bjnano.15.3

• channels, one main channel at 145 GHz with 30% bandwidth, and two auxiliary channels at 210 GHz with 20% bandwidth and at 240 GHz with 10% bandwidth [3]. It is planned that multimodal TESs with spider-web antennas will be used as detecting elements in the current implementation of this project [8]. These

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• a low-power laser source. In a multimodal system of gold, iron oxide, and graphene oxide (GO) nanoparticles, the photothermal properties of graphene, the magnetic properties of iron oxide, and the surface plasmon resonance of gold enable multiple functions in a single system. The presence of gold

• 532 and 808 nm, the nanocomposite exhibited both photodynamic and photothermal properties. The same construct could be useful to design biosensors for the multimodal detection of analytes [85]. Recently, a catalytic and photothermal sensor was developed by Lu et al. for the detection of Salmonella

• diagnostic technologies. With further refinement and advancements, GNC-based photothermal assays could revolutionize the field of point-of-care diagnostics and reliable disease detection. Recent studies have proven the applicability of multimodal LFAs for accurate and quantitative diagnosis. Yang et al

Carboxylic acids and light interact to affect nanoceria stability and dissolution in acidic aqueous environments

• Matthew L. Hancock,
• Eric A. Grulke and
• Robert A. Yokel

Beilstein J. Nanotechnol. 2023, 14, 762–780, doi:10.3762/bjnano.14.63

• completed for each sample, and the average result of each run was analyzed and recorded. All samples were evaluated using the multimodal setting. Nanoceria, 1 mg, was dispersed in 2 mL (500 µg/mL) of 0.11 M iso-osmotic aqueous media at pH 4.5 representative of acidic soil and lysosomes [57][58]. Throughout

The steep road to nonviral nanomedicines: Frequent challenges and culprits in designing nanoparticles for gene therapy

• Yao Yao,
• Yeongun Ko,
• Grant Grasman,
• Jeffery E. Raymond and
• Joerg Lahann

Beilstein J. Nanotechnol. 2023, 14, 351–361, doi:10.3762/bjnano.14.30

• overview of the current status and outline important concerns regarding the need for standardized protocols to evaluate NP uptake, NP transfection efficacy, drug dose determination, and variability of nonviral gene delivery systems. Based on these concerns, we propose wide adherence to multimodal

• note, this perspective is not intended to provide a comprehensive overview of the best practice (for such comprehensive reviews the reader is referred to for instance Rennick et al. [1]), but rather aims at highlighting the importance of multimodal, multiparameter, and multistudy analysis of NP systems

• Need for Multimodal Characterization of Nanoparticles The methods chosen to investigate NP uptake and transfection can be biased towards particular properties and may provide limited insights into the efficiency of NP internalization and efficacy. Typically, cellular uptake and transfection efficiency

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• the ability to target tumor tissue and enable multimodal imaging was fabricated for more efficient diagnosis and treatment by the Shu group. The biomimetic nanoformulation utilized hollow mesoporous Prussian blue nanoparticles as the core, endowing it with photothermal conversion and photoacoustic

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• lung cancers. A plethora of multimodal treatments for the co-administration of: (i) conventional cytotoxic agents with signaling pathway inhibitor/s, (ii) inhibitors of two or more signaling pathways within a signaling network, (iii) inhibitors of multiple targets within a single pathway exerting

• growth factor inhibition in vitro, maintaining its biological efficacy in cells and xenograft models with different mutation statuses [70][72][73][74]. Further advances in the multimodal combination therapy approach KRAS proteins operate as guanosine diphosphate (GDP)/guanosine triphosphate (GTP

A cantilever-based, ultrahigh-vacuum, low-temperature scanning probe instrument for multidimensional scanning force microscopy

• Hao Liu,
• Zuned Ahmed,
• Sasa Vranjkovic,
• Manfred Parschau,
• Andrada-Oana Mandru and
• Hans J. Hug

Beilstein J. Nanotechnol. 2022, 13, 1120–1140, doi:10.3762/bjnano.13.95

• properties using multifrequency and multimodal AFM operation modes. Research of new quantum materials and devices, however, often requires low temperatures and ultrahigh vacuum (UHV) conditions and, more specifically, AFM instrumentation providing atomic resolution. For this, AFM instrumentation based on a

• tuning fork force sensor became increasingly popular. In comparison to microfabricated cantilevers, the more macroscopic tuning forks, however, lack sensitivity, which limits the measurement bandwidth. Moreover, multimodal and multifrequency techniques, such as those available in cantilever-based AFM

• cantilever-based AFM offers experimental flexibility by permitting multimodal or multifrequency operations with superior force derivative sensitivities and bandwidths. Our instrument has a sub-picometer gap stability and can simultaneously map not only vertical and lateral forces with atomic-scale resolution

The role of convolutional neural networks in scanning probe microscopy: a review

• Ido Azuri,
• Irit Rosenhek-Goldian,
• Neta Regev-Rudzki,
• Georg Fantner and
• Sidney R. Cohen

Beilstein J. Nanotechnol. 2021, 12, 878–901, doi:10.3762/bjnano.12.66

• using that association to categorize, identify, and isolate subsets of the data. Scanning probe microscopy measures multimodal surface properties, combining morphology with electronic, mechanical, and other characteristics. In this review, we focus on a subset of deep learning algorithms, that is

• molecules, the test set can be generated computationally from first principles. Various fast-scanning approaches have also been applied. Augmentation techniques are often required. Another characteristic of SPM is that it is multimodal. One scan can provide multiple mappings simultaneously with the

• multimodal and non-imaging techniques As mentioned at the beginning of this section, one of the strengths of SPM is that it is multimodal, that is, several different physical phenomena are measured in one scan. This was exemplified by application of a CNN to extract physical information under low S/N

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• combinations have been used in theranostics for simultaneous imaging and drug delivery [182][183][184] or for multimodal imaging [185]. Microbubbles can enhance the endocytosis process by affecting cell signaling pathways [186]. One study showed that MBs, in addition to US irradiation, had a synergistic effect

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• -exposed molecules. Considering that leukemia has shown a vast genomic heterogeneity, the integration of the molecular profile of the tumor into the design of the multimodal nanoscale carriers will have a tremendous impact for the future development of personalized nanomedicine for a safe and efficacious

Intracranial recording in patients with aphasia using nanomaterial-based flexible electronics: promises and challenges

• Qingchun Wang and
• Wai Ting Siok

Beilstein J. Nanotechnol. 2021, 12, 330–342, doi:10.3762/bjnano.12.27

• visual or multimodal images of words. Both regions showed stronger activity to letter strings than objects, implying their specific role in orthographic processing [50][51]. Based on previous neuroimaging studies with epileptic patients, Cohen et al. [51] proposed the visual word form area (VWFA

• methods. McDonald et al. [58] conducted a multimodal imaging study to investigate word processing in both healthy people and patients with epilepsy. Twelve healthy participants completed a semantics judgement task while being evaluated with fMRI and MEG, and six patients performed the same task while

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

• Cynthia Kembuan,
• Helena Oliveira and
• Christina Graf

Beilstein J. Nanotechnol. 2021, 12, 35–48, doi:10.3762/bjnano.12.3

• chemical inertness and relatively low toxicity are also claimed advantages [7][10][11]. Due to these unique features, UCNPs have already been used in medical and biological applications, such as multimodal bioimaging, drug delivery, photodynamic therapy, and biosensing [9][12][13][14][15][16][17]. However

Uniform Fe₃O₄/Gd₂O₃-DHCA nanocubes for dual-mode magnetic resonance imaging

• Miao Qin,
• Yueyou Peng,
• Mengjie Xu,
• Hui Yan,
• Yizhu Cheng,
• Xiumei Zhang,
• Di Huang,
• Weiyi Chen and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2020, 11, 1000–1009, doi:10.3762/bjnano.11.84

• multimodal magnetic resonance imaging (MRI) technique has been extensively studied over the past few years since it offers complementary information that can increase diagnostic accuracy. Simple methods to synthesize contrast agents are necessary for the development of multimodal MRI. Herein, uniformly

• into multimodal contrast agents in order to synergistically maximize their advantages while compensating for their drawbacks [20][21]. In addition, this strategy also allows for complementary diagnostic information, which can improve the sensitivity and reliability in detecting lesions. Given that

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• is an example of “all in one“ nanomedicine used for chemotherapy combining loading with doxorubicin, PDT and PTT. This is possible thanks to the activation of the photosensitizer and multimodal imaging using the fluorescence of the photosensitizer (near-infrared fluorescence imaging, NIRFI) and the

• design point to the development of versatile and “all in one” nanocarriers embedding different functions in order to both visualize the tumor and kill it. For this purpose, PDT has been associated with multimodal imaging and other treatments such as chemotherapy or photothermal therapy (PTT). Doxorubicin

A review of demodulation techniques for multifrequency atomic force microscopy

• David M. Harcombe,
• Michael G. Ruppert and
• Andrew J. Fleming

Beilstein J. Nanotechnol. 2020, 11, 76–91, doi:10.3762/bjnano.11.8

• components. Small interaction forces associated with higher-harmonic AFM have been imaged in free air [18] as well as liquid [19]. This has lead to relatively large biological objects being imaged including viruses [20] and cells [21]. Multimodal AFM, where two or more resonance frequencies are driven, has

Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells

• Mohammad J. Akbar,
• Pâmela C. Lukasewicz Ferreira,
• Melania Giorgetti,
• Leanne Stokes and
• Christopher J. Morris

Beilstein J. Nanotechnol. 2019, 10, 2553–2562, doi:10.3762/bjnano.10.246

• function of both incubation time and temperature. For example, the control-lipo vesicles increased to 125 nm diameter after 24 or 72 h incubation at 37 °C. We noted a transition from a unimodal size distribution of liposomes in PBS buffer to a multimodal size distribution after extended incubation with 10

Small protein sequences can induce cellular uptake of complex nanohybrids

• Jan-Philip Merkl,
• Malak Safi,
• Christian Schmidtke,
• Fadi Aldeek,
• Johannes Ostermann,
• Tatiana Domitrovic,
• Sebastian Gärtner,
• John E. Johnson,
• Horst Weller and
• Hedi Mattoussi

Beilstein J. Nanotechnol. 2019, 10, 2477–2482, doi:10.3762/bjnano.10.238

• nanostructures made of more than one component nanomaterial, combined with biomolecules is a highly sought goal in biomedical science, and can find applications in multimodal imaging and therapeutics [1][2]. Although interest in developing such hybrid nanostructures by, for example, combining plasmonic and

• macrophages to these hybrid materials combined with an improvement in their in vivo tumour accumulation [6]. Weil and co-workers described the use of multimodal platforms, made of diamond dots combined with gold nanoparticles, as imaging probes of live cell cultures [7]. We have recently characterized a

Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration

• Nashrawan Lababidi,
• Valentin Sigal,
• Aljoscha Koenneke,
• Konrad Schwarzkopf,
• Andreas Manz and
• Marc Schneider

Beilstein J. Nanotechnol. 2019, 10, 2280–2293, doi:10.3762/bjnano.10.220

• 0.05 (0.27 ms) in contrast to τmix = 2.19 ms at a FRR of 0.6. Additionally, a focus channel of 50 µm was tested, but this, unfortunately, resulted in a multimodal size distribution of NPs, which is most likely due to the non-stable flow pattern (turbulent flow instead of laminar flow). Effect of

Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications

• Alberto Boretti,
• Lorenzo Rosa,
• Jonathan Blackledge and
• Stefania Castelletto

Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207

• the singlet state. Magnetic nanoparticles (MNPs) can act as contrast agents [16] to improve the imaging of tumors in specific cancer MRI. Multimodal imaging has been recently made possible by functionalizing the particle surface with biocompatible chemicals, where surface coverings (such as the

Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging: effective stabilization via fluorous interactions

• Da Shi,
• Justine Wallyn,
• Dinh-Vu Nguyen,
• Francis Perton,
• Delphine Felder-Flesch,
• Sylvie Bégin-Colin,
• Mounir Maaloum and
• Marie Pierre Krafft

Beilstein J. Nanotechnol. 2019, 10, 2103–2115, doi:10.3762/bjnano.10.205

• osmotic agent [14][15] and as a co-surfactant to phospholipids [16] and block co-polymers [17]. Nanoparticles can be attached to the bubble shells to extend their diagnostic and therapeutic potential by combining multimodal imaging, drug or gene delivery, and/or enhancement and control of the acoustic

Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting

• Xianping Liu,
• Chengjuan Du,
• Haichun Li,
• Ting Jiang,
• Zimiao Luo,
• Zhiqing Pang,
• Daoying Geng and
• Jun Zhang

Beilstein J. Nanotechnol. 2019, 10, 1860–1872, doi:10.3762/bjnano.10.181

• bimodal imaging capability, this novel and versatile multimodal nanoprobe could bring a new perspective for elucidating intracranial glioblastoma preoperative diagnosis and the accuracy of tumor resection. Keywords: epidermal growth factor receptor variant III (EGFRvIII); glioblastoma; magnetic resonance

• for sensitive characterization and detection of glioblastoma. Compared with single mode imaging, multimodal imaging can facilitate early cancer detection, providing a more comprehensive and multidimensional description of tumor biological behavior [27][28][29]. Optical imaging enables the

• multimodal imaging nanoprobe, which has both high sensitivity and high spatial resolution for early and precise detection and localization of glioblastoma, is constructed in this work. The multimodal imaging of EGFRvIII overexpression in glioblastoma was performed using Cy7.5-labeled SPIONs with EGFRvIII

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• theranostics in the future. Keywords: Au nanorods; cancer theranostics; fluorescent bioimaging; folate; polydopamine; targeted phototherapy; Introduction Multifunctional imaging and combined multimodal therapy strategies are very promising in cancer theranostics [1][2]. Possible way for such purpose is to

• efficient multimodal cancer treatments both in vitro and in vivo. An ideal nanorod coating for efficient nanocomposite formation should meet several important criteria. First, the resulting nanoparticles should be nontoxic and colloidally stable in blood serum. Second, the shell should have high loading