Self-assembled anchor layers/polysaccharide coatings on titanium surfaces: a study of functionalization and stability

• Ognen Pop-Georgievski,
• Dana Kubies,
• Josef Zemek,
• Neda Neykova,
• Roman Demianchuk,
• Eliška Mázl Chánová,
• Miroslav Šlouf,
• Milan Houska and
• František Rypáček

Beilstein J. Nanotechnol. 2015, 6, 617–631, doi:10.3762/bjnano.6.63

• anchoring layers of self-assembled bisphosphonate neridronate monolayers and polymer films of 3-aminopropyltriethoxysilane and biomimetic poly(dopamine). These were further used to bind a bio-functional alginate coating. The success of the titanium surface activation, anchoring layer formation and alginate

• ; neridronate; poly(dopamine); spectroscopic ellipsometry; surface characterization; surface modification; titanium; XPS; Introduction Titanium and titanium alloys are widely used in medicine and dentistry to replace and support hard tissues [1]. The absence of toxic alloying metals [1], extraordinary specific

• controlled cell adhesion [37]. The presence of amine groups in PDA has been used for functionalization with moieties for photo-induced grafting reactions [38][39]. In this work, we study the immobilization of three compounds to the titanium surface: bisphosphonate neridronate, APTES and PDA. The neridronate