Continuous parallel ESI-MS analysis of reactions carried out in a bespoke 3D printed device

• Jennifer S. Mathieson,
• Mali H. Rosnes,
• Victor Sans,
• Philip J. Kitson and
• Leroy Cronin

Beilstein J. Nanotechnol. 2013, 4, 285–291, doi:10.3762/bjnano.4.31

• parallel analysis; ESI-MS; 3D printing; reactionware; supramolecular chemistry; Introduction Flow chemistry is a growing field that can increase productivity and control, ensure reproducibility and reduce manual handling [1]. There is currently a huge interest in directly interfacing milli- and

• /outcome. Traditionally, when interfacing flow devices with ESI-MS analysis complicated and expensive microscale fluidic devices have been required. Herein, we present an approach interfacing ESI-MS with a 3D-printed milliscale device, or tailored “reactionware” [4]. The use of 3D printing bypasses

• manipulation of reaction environment results in strict control of the final device and the subsequent reactions carried out. We have previously demonstrated the versatility and configurability of reusable and bespoke reactionware, in which a 3D-printed “reactionware” matrix, with the reagents printed directly