Influence of gold, silver and gold–silver alloy nanoparticles on germ cell function and embryo development

• Ulrike Taylor,
• Daniela Tiedemann,
• Christoph Rehbock,
• Wilfried A. Kues,
• Stephan Barcikowski and
• Detlef Rath

Beilstein J. Nanotechnol. 2015, 6, 651–664, doi:10.3762/bjnano.6.66

• design of nanoparticles with increased biosafety is highly relevant for biomedical applications. Keywords: bimetallic nanoparticles, nano gold; nano silver; ontogenesis, oocyte; reprotoxicity; spermatozoa; Review Reprotoxicology Repotoxicological studies are a mandatory part during every stage of drug

• developmental anomalies of the emerging embryos [72]. Future research needs to clarify the effect of nanoparticle exposure on the fertilising capability of spermatozoa, since it has proven to be a sensitive indicator of nanoparticle reprotoxicity. A valuable tool for such examinations could be recently