Biological responses to NPs

  1. editorImage
  1. Editor: Prof. Reinhard Zellner
    Universität Duisburg-Essen

Nanoscale particles are known to exhibit novel properties that make them different from their corresponding bulk-scale materials. Concerns have been raised that the very same properties that make them interesting might also have negative health effects, which cannot easily be derived from the known toxicity of the macroscopic material. Hence, major gaps in the knowledge necessary for assessing their risk to human health currently exist. There is also a lack of existing methodologies to improve techniques for nanoparticle characterization, their detection in biological systems, as well as the biological activity of such systems. The complexity of this problem is amplified by the huge variety of nanoscale materials and potential biomolecules and cells. This special issue mostly contains mini-reviews, which summarize the current and previous work of the contributing groups performing research in this field.

  • Editorial
  • Published 05 Feb 2015

Beilstein J. Nanotechnol. 2015, 6, 380–382, doi:10.3762/bjnano.6.37

Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats

  1. Nadine Haberl,
  2. Stephanie Hirn,
  3. Alexander Wenk,
  4. Jörg Diendorf,
  5. Matthias Epple,
  6. Blair D. Johnston,
  7. Fritz Krombach,
  8. Wolfgang G. Kreyling and
  9. Carsten Schleh
  • Full Research Paper
  • Published 19 Dec 2013

  • PDF

Beilstein J. Nanotechnol. 2013, 4, 933–940, doi:10.3762/bjnano.4.105

Injection of ligand-free gold and silver nanoparticles into murine embryos does not impact pre-implantation development

  1. Ulrike Taylor,
  2. Wiebke Garrels,
  3. Annette Barchanski,
  4. Svea Peterson,
  5. Laszlo Sajti,
  6. Andrea Lucas-Hahn,
  7. Lisa Gamrad,
  8. Ulrich Baulain,
  9. Sabine Klein,
  10. Wilfried A. Kues,
  11. Stephan Barcikowski and
  12. Detlef Rath
  • Full Research Paper
  • Published 21 May 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 677–688, doi:10.3762/bjnano.5.80

Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches

  1. Fabian Herzog,
  2. Kateryna Loza,
  3. Sandor Balog,
  4. Martin J. D. Clift,
  5. Matthias Epple,
  6. Peter Gehr,
  7. Alke Petri-Fink and
  8. Barbara Rothen-Rutishauser
  • Full Research Paper
  • Published 26 Aug 2014

  • PDF

  • Supp. Info

Beilstein J. Nanotechnol. 2014, 5, 1357–1370, doi:10.3762/bjnano.5.149

The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles

  1. Dominic Docter,
  2. Christoph Bantz,
  3. Dana Westmeier,
  4. Hajo J. Galla,
  5. Qiangbin Wang,
  6. James C. Kirkpatrick,
  7. Peter Nielsen,
  8. Michael Maskos and
  9. Roland H. Stauber
  • Full Research Paper
  • Published 27 Aug 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 1380–1392, doi:10.3762/bjnano.5.151

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver

  1. Markus Heine,
  2. Alexander Bartelt,
  3. Oliver T. Bruns,
  4. Denise Bargheer,
  5. Artur Giemsa,
  6. Barbara Freund,
  7. Ludger Scheja,
  8. Christian Waurisch,
  9. Alexander Eychmüller,
  10. Rudolph Reimer,
  11. Horst Weller,
  12. Peter Nielsen and
  13. Joerg Heeren
  • Full Research Paper
  • Published 02 Sep 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 1432–1440, doi:10.3762/bjnano.5.155

In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

  1. Moritz Nazarenus,
  2. Qian Zhang,
  3. Mahmoud G. Soliman,
  4. Pablo del Pino,
  5. Beatriz Pelaz,
  6. Susana Carregal-Romero,
  7. Joanna Rejman,
  8. Barbara Rothen-Rutishauser,
  9. Martin J. D. Clift,
  10. Reinhard Zellner,
  11. G. Ulrich Nienhaus,
  12. James B. Delehanty,
  13. Igor L. Medintz and
  14. Wolfgang J. Parak
  • Review
  • Published 09 Sep 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 1477–1490, doi:10.3762/bjnano.5.161

Current state of laser synthesis of metal and alloy nanoparticles as ligand-free reference materials for nano-toxicological assays

  1. Christoph Rehbock,
  2. Jurij Jakobi,
  3. Lisa Gamrad,
  4. Selina van der Meer,
  5. Daniela Tiedemann,
  6. Ulrike Taylor,
  7. Wilfried Kues,
  8. Detlef Rath and
  9. Stephan Barcikowski
  • Review
  • Published 12 Sep 2014

  • PDF

  • Video

Beilstein J. Nanotechnol. 2014, 5, 1523–1541, doi:10.3762/bjnano.5.165

Silica nanoparticles are less toxic to human lung cells when deposited at the air–liquid interface compared to conventional submerged exposure

  1. Alicja Panas,
  2. Andreas Comouth,
  3. Harald Saathoff,
  4. Thomas Leisner,
  5. Marco Al-Rawi,
  6. Michael Simon,
  7. Gunnar Seemann,
  8. Olaf Dössel,
  9. Sonja Mülhopt,
  10. Hanns-Rudolf Paur,
  11. Susanne Fritsch-Decker,
  12. Carsten Weiss and
  13. Silvia Diabaté
  • Full Research Paper
  • Published 19 Sep 2014

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  • Supp. Info

Beilstein J. Nanotechnol. 2014, 5, 1590–1602, doi:10.3762/bjnano.5.171

  • Full Research Paper
  • Published 23 Sep 2014

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Beilstein J. Nanotechnol. 2014, 5, 1616–1624, doi:10.3762/bjnano.5.173

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages

  1. Dagmar A. Kuhn,
  2. Dimitri Vanhecke,
  3. Benjamin Michen,
  4. Fabian Blank,
  5. Peter Gehr,
  6. Alke Petri-Fink and
  7. Barbara Rothen-Rutishauser
  • Full Research Paper
  • Published 24 Sep 2014

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  • Supp. Info

Beilstein J. Nanotechnol. 2014, 5, 1625–1636, doi:10.3762/bjnano.5.174

In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics

  1. Wolfgang G. Kreyling,
  2. Stefanie Fertsch-Gapp,
  3. Martin Schäffler,
  4. Blair D. Johnston,
  5. Nadine Haberl,
  6. Christian Pfeiffer,
  7. Jörg Diendorf,
  8. Carsten Schleh,
  9. Stephanie Hirn,
  10. Manuela Semmler-Behnke,
  11. Matthias Epple and
  12. Wolfgang J. Parak
  • Review
  • Published 02 Oct 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 1699–1711, doi:10.3762/bjnano.5.180

The surface properties of nanoparticles determine the agglomeration state and the size of the particles under physiological conditions

  1. Christoph Bantz,
  2. Olga Koshkina,
  3. Thomas Lang,
  4. Hans-Joachim Galla,
  5. C. James Kirkpatrick,
  6. Roland H. Stauber and
  7. Michael Maskos
  • Full Research Paper
  • Published 15 Oct 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 1774–1786, doi:10.3762/bjnano.5.188

  • Full Research Paper
  • Published 17 Oct 2014

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  • Supp. Info

Beilstein J. Nanotechnol. 2014, 5, 1795–1807, doi:10.3762/bjnano.5.190

Imaging the intracellular degradation of biodegradable polymer nanoparticles

  1. Anne-Kathrin Barthel,
  2. Martin Dass,
  3. Melanie Dröge,
  4. Jens-Michael Cramer,
  5. Daniela Baumann,
  6. Markus Urban,
  7. Katharina Landfester,
  8. Volker Mailänder and
  9. Ingo Lieberwirth
  • Full Research Paper
  • Published 29 Oct 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 1905–1917, doi:10.3762/bjnano.5.201

PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments

  1. Sebastian Ahlberg,
  2. Alexandra Antonopulos,
  3. Jörg Diendorf,
  4. Ralf Dringen,
  5. Matthias Epple,
  6. Rebekka Flöck,
  7. Wolfgang Goedecke,
  8. Christina Graf,
  9. Nadine Haberl,
  10. Jens Helmlinger,
  11. Fabian Herzog,
  12. Frederike Heuer,
  13. Stephanie Hirn,
  14. Christian Johannes,
  15. Stefanie Kittler,
  16. Manfred Köller,
  17. Katrin Korn,
  18. Wolfgang G. Kreyling,
  19. Fritz Krombach,
  20. Jürgen Lademann,
  21. Kateryna Loza,
  22. Eva M. Luther,
  23. Marcelina Malissek,
  24. Martina C. Meinke,
  25. Daniel Nordmeyer,
  26. Anne Pailliart,
  27. Jörg Raabe,
  28. Fiorenza Rancan,
  29. Barbara Rothen-Rutishauser,
  30. Eckart Rühl,
  31. Carsten Schleh,
  32. Andreas Seibel,
  33. Christina Sengstock,
  34. Lennart Treuel,
  35. Annika Vogt,
  36. Katrin Weber and
  37. Reinhard Zellner
  • Review
  • Published 03 Nov 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 1944–1965, doi:10.3762/bjnano.5.205

Rapid degradation of zinc oxide nanoparticles by phosphate ions

  1. Rudolf Herrmann,
  2. F. Javier García-García and
  3. Armin Reller
  • Full Research Paper
  • Published 05 Nov 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2007–2015, doi:10.3762/bjnano.5.209

Data-adaptive image-denoising for detecting and quantifying nanoparticle entry in mucosal tissues through intravital 2-photon microscopy

  1. Torsten Bölke,
  2. Lisa Krapf,
  3. Regina Orzekowsky-Schroeder,
  4. Tobias Vossmeyer,
  5. Jelena Dimitrijevic,
  6. Horst Weller,
  7. Anna Schüth,
  8. Antje Klinger,
  9. Gereon Hüttmann and
  10. Andreas Gebert
  • Full Research Paper
  • Published 06 Nov 2014

  • PDF

  • Supp. Info

Beilstein J. Nanotechnol. 2014, 5, 2016–2025, doi:10.3762/bjnano.5.210

Effects of surface functionalization on the adsorption of human serum albumin onto nanoparticles – a fluorescence correlation spectroscopy study

  1. Pauline Maffre,
  2. Stefan Brandholt,
  3. Karin Nienhaus,
  4. Li Shang,
  5. Wolfgang J. Parak and
  6. G. Ulrich Nienhaus
  • Full Research Paper
  • Published 07 Nov 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2036–2047, doi:10.3762/bjnano.5.212

Effect of silver nanoparticles on human mesenchymal stem cell differentiation

  1. Christina Sengstock,
  2. Jörg Diendorf,
  3. Matthias Epple,
  4. Thomas A. Schildhauer and
  5. Manfred Köller
  • Full Research Paper
  • Published 10 Nov 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2058–2069, doi:10.3762/bjnano.5.214

The gut wall provides an effective barrier against nanoparticle uptake

  1. Heike Sinnecker,
  2. Thorsten Krause,
  3. Sabine Koelling,
  4. Ingmar Lautenschläger and
  5. Andreas Frey
  • Full Research Paper
  • Published 12 Nov 2014

  • PDF

  • Supp. Info

Beilstein J. Nanotechnol. 2014, 5, 2092–2101, doi:10.3762/bjnano.5.218

  • Full Research Paper
  • Published 02 Dec 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2308–2315, doi:10.3762/bjnano.5.239

Inorganic Janus particles for biomedical applications

  1. Isabel Schick,
  2. Steffen Lorenz,
  3. Dominik Gehrig,
  4. Stefan Tenzer,
  5. Wiebke Storck,
  6. Karl Fischer,
  7. Dennis Strand,
  8. Frédéric Laquai and
  9. Wolfgang Tremel
  • Review
  • Published 05 Dec 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2346–2362, doi:10.3762/bjnano.5.244

Interaction of dermatologically relevant nanoparticles with skin cells and skin

  1. Annika Vogt,
  2. Fiorenza Rancan,
  3. Sebastian Ahlberg,
  4. Berouz Nazemi,
  5. Chun Sik Choe,
  6. Maxim E. Darvin,
  7. Sabrina Hadam,
  8. Ulrike Blume-Peytavi,
  9. Kateryna Loza,
  10. Jörg Diendorf,
  11. Matthias Epple,
  12. Christina Graf,
  13. Eckart Rühl,
  14. Martina C. Meinke and
  15. Jürgen Lademann
  • Full Research Paper
  • Published 08 Dec 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2363–2373, doi:10.3762/bjnano.5.245

Synthesis of radioactively labelled CdSe/CdS/ZnS quantum dots for in vivo experiments

  1. Gordon M. Stachowski,
  2. Christoph Bauer,
  3. Christian Waurisch,
  4. Denise Bargheer,
  5. Peter Nielsen,
  6. Jörg Heeren,
  7. Stephen G. Hickey and
  8. Alexander Eychmüller
  • Full Research Paper
  • Published 10 Dec 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2383–2387, doi:10.3762/bjnano.5.247

Nanoparticle interactions with live cells: Quantitative fluorescence microscopy of nanoparticle size effects

  1. Li Shang,
  2. Karin Nienhaus,
  3. Xiue Jiang,
  4. Linxiao Yang,
  5. Katharina Landfester,
  6. Volker Mailänder,
  7. Thomas Simmet and
  8. G. Ulrich Nienhaus
  • Full Research Paper
  • Published 11 Dec 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2388–2397, doi:10.3762/bjnano.5.248

Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

  1. Cornelia Loos,
  2. Tatiana Syrovets,
  3. Anna Musyanovych,
  4. Volker Mailänder,
  5. Katharina Landfester,
  6. G. Ulrich Nienhaus and
  7. Thomas Simmet
  • Review
  • Published 15 Dec 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2403–2412, doi:10.3762/bjnano.5.250

  • Review
  • Published 16 Dec 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2413–2423, doi:10.3762/bjnano.5.251

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices

  1. Stephanie Hirn,
  2. Nadine Haberl,
  3. Kateryna Loza,
  4. Matthias Epple,
  5. Wolfgang G. Kreyling,
  6. Barbara Rothen-Rutishauser,
  7. Markus Rehberg and
  8. Fritz Krombach
  • Full Research Paper
  • Published 18 Dec 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2440–2449, doi:10.3762/bjnano.5.253

Intake of silica nanoparticles by giant lipid vesicles: influence of particle size and thermodynamic membrane state

  1. Florian G. Strobl,
  2. Florian Seitz,
  3. Christoph Westerhausen,
  4. Armin Reller,
  5. Adriano A. Torrano,
  6. Christoph Bräuchle,
  7. Achim Wixforth and
  8. Matthias F. Schneider
  • Full Research Paper
  • Published 23 Dec 2014

  • PDF

Beilstein J. Nanotechnol. 2014, 5, 2468–2478, doi:10.3762/bjnano.5.256

Mammalian cell growth on gold nanoparticle-decorated substrates is influenced by the nanoparticle coating

  1. Christina Rosman,
  2. Sebastien Pierrat,
  3. Marco Tarantola,
  4. David Schneider,
  5. Eva Sunnick,
  6. Andreas Janshoff and
  7. Carsten Sönnichsen
  • Full Research Paper
  • Published 24 Dec 2014

  • PDF

  • Supp. Info

Beilstein J. Nanotechnol. 2014, 5, 2479–2488, doi:10.3762/bjnano.5.257

The fate of a designed protein corona on nanoparticles in vitro and in vivo

  1. Denise Bargheer,
  2. Julius Nielsen,
  3. Gabriella Gébel,
  4. Markus Heine,
  5. Sunhild C. Salmen,
  6. Roland Stauber,
  7. Horst Weller,
  8. Joerg Heeren and
  9. Peter Nielsen
  • Full Research Paper
  • Published 06 Jan 2015

  • PDF

Beilstein J. Nanotechnol. 2015, 6, 36–46, doi:10.3762/bjnano.6.5

The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice

  1. Denise Bargheer,
  2. Artur Giemsa,
  3. Barbara Freund,
  4. Markus Heine,
  5. Christian Waurisch,
  6. Gordon M. Stachowski,
  7. Stephen G. Hickey,
  8. Alexander Eychmüller,
  9. Jörg Heeren and
  10. Peter Nielsen
  • Full Research Paper
  • Published 09 Jan 2015

  • PDF

Beilstein J. Nanotechnol. 2015, 6, 111–123, doi:10.3762/bjnano.6.11

  • Full Research Paper
  • Published 14 Jan 2015

  • PDF

Beilstein J. Nanotechnol. 2015, 6, 167–176, doi:10.3762/bjnano.6.16

Mechanical properties of MDCK II cells exposed to gold nanorods

  1. Anna Pietuch,
  2. Bastian Rouven Brückner,
  3. David Schneider,
  4. Marco Tarantola,
  5. Christina Rosman,
  6. Carsten Sönnichsen and
  7. Andreas Janshoff
  • Full Research Paper
  • Published 20 Jan 2015

  • PDF

Beilstein J. Nanotechnol. 2015, 6, 223–231, doi:10.3762/bjnano.6.21

Tailoring the ligand shell for the control of cellular uptake and optical properties of nanocrystals

  1. Johannes Ostermann,
  2. Christian Schmidtke,
  3. Christopher Wolter,
  4. Jan-Philip Merkl,
  5. Hauke Kloust and
  6. Horst Weller
  • Review
  • Published 21 Jan 2015

  • PDF

  • Supp. Info

Beilstein J. Nanotechnol. 2015, 6, 232–242, doi:10.3762/bjnano.6.22

Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

  1. Anja Ostrowski,
  2. Daniel Nordmeyer,
  3. Alexander Boreham,
  4. Cornelia Holzhausen,
  5. Lars Mundhenk,
  6. Christina Graf,
  7. Martina C. Meinke,
  8. Annika Vogt,
  9. Sabrina Hadam,
  10. Jürgen Lademann,
  11. Eckart Rühl,
  12. Ulrike Alexiev and
  13. Achim D. Gruber
  • Review
  • Published 23 Jan 2015

  • PDF

Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25

The effect of surface charge on nonspecific uptake and cytotoxicity of CdSe/ZnS core/shell quantum dots

  1. Vladimir V. Breus,
  2. Anna Pietuch,
  3. Marco Tarantola,
  4. Thomas Basché and
  5. Andreas Janshoff
  • Full Research Paper
  • Published 26 Jan 2015

  • PDF

  • Supp. Info

Beilstein J. Nanotechnol. 2015, 6, 281–292, doi:10.3762/bjnano.6.26

Comparative evaluation of the impact on endothelial cells induced by different nanoparticle structures and functionalization

  1. Lisa Landgraf,
  2. Ines Müller,
  3. Peter Ernst,
  4. Miriam Schäfer,
  5. Christina Rosman,
  6. Isabel Schick,
  7. Oskar Köhler,
  8. Hartmut Oehring,
  9. Vladimir V. Breus,
  10. Thomas Basché,
  11. Carsten Sönnichsen,
  12. Wolfgang Tremel and
  13. Ingrid Hilger
  • Full Research Paper
  • Published 27 Jan 2015

  • PDF

  • Supp. Info

Beilstein J. Nanotechnol. 2015, 6, 300–312, doi:10.3762/bjnano.6.28

Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation

  1. Ivonne Brüstle,
  2. Thomas Simmet,
  3. Gerd Ulrich Nienhaus,
  4. Katharina Landfester and
  5. Volker Mailänder
  • Full Research Paper
  • Published 05 Feb 2015

  • PDF

  • Supp. Info

Beilstein J. Nanotechnol. 2015, 6, 383–395, doi:10.3762/bjnano.6.38

A surface acoustic wave-driven micropump for particle uptake investigation under physiological flow conditions in very small volumes

  1. Florian G. Strobl,
  2. Dominik Breyer,
  3. Phillip Link,
  4. Adriano A. Torrano,
  5. Christoph Bräuchle,
  6. Matthias F. Schneider and
  7. Achim Wixforth
  • Full Research Paper
  • Published 09 Feb 2015

  • PDF

Beilstein J. Nanotechnol. 2015, 6, 414–419, doi:10.3762/bjnano.6.41

Pulmonary surfactant augments cytotoxicity of silica nanoparticles: Studies on an in vitro air–blood barrier model

  1. Jennifer Y. Kasper,
  2. Lisa Feiden,
  3. Maria I. Hermanns,
  4. Christoph Bantz,
  5. Michael Maskos,
  6. Ronald E. Unger and
  7. C. James Kirkpatrick
  • Full Research Paper
  • Published 20 Feb 2015

  • PDF

Beilstein J. Nanotechnol. 2015, 6, 517–528, doi:10.3762/bjnano.6.54

Influence of gold, silver and gold–silver alloy nanoparticles on germ cell function and embryo development

  1. Ulrike Taylor,
  2. Daniela Tiedemann,
  3. Christoph Rehbock,
  4. Wilfried A. Kues,
  5. Stephan Barcikowski and
  6. Detlef Rath
  • Full Research Paper
  • Published 05 Mar 2015

  • PDF

  • Video

Beilstein J. Nanotechnol. 2015, 6, 651–664, doi:10.3762/bjnano.6.66

Protein corona – from molecular adsorption to physiological complexity

  1. Lennart Treuel,
  2. Dominic Docter,
  3. Michael Maskos and
  4. Roland H. Stauber
  • Review
  • Published 30 Mar 2015

  • PDF

Beilstein J. Nanotechnol. 2015, 6, 857–873, doi:10.3762/bjnano.6.88

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