Supporting Information
| Supporting Information File 1: Experimental part. | ||
| Format: PDF | Size: 2.0 MB | Download |
Cite the Following Article
Fluorinated cyclohexanes: Synthesis of amine building blocks of the all-cis 2,3,5,6-tetrafluorocyclohexylamine motif
Tetiana Bykova, Nawaf Al-Maharik, Alexandra M. Z. Slawin and David O'Hagan
Beilstein J. Org. Chem. 2017, 13, 728–733.
https://doi.org/10.3762/bjoc.13.72
How to Cite
Bykova, T.; Al-Maharik, N.; Slawin, A. M. Z.; O'Hagan, D. Beilstein J. Org. Chem. 2017, 13, 728–733. doi:10.3762/bjoc.13.72
Download Citation
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window
below.
Citation data in RIS format can be imported by all major citation management software, including EndNote,
ProCite, RefWorks, and Zotero.
Presentation Graphic
| Picture with graphical abstract, title and authors for social media postings and presentations. | ||
| Format: PNG | Size: 123.5 KB | Download |
Citations to This Article
Up to 20 of the most recent references are displayed here.
Scholarly Works
- O'Hagan, D. The Emergence and Properties of Selectively Fluorinated 'Janus' Cyclohexanes. Chemical record (New York, N.Y.) 2023, 23, e202300027. doi:10.1002/tcr.202300027
- Grygorenko, O. O.; Melnykov, K. P.; Holovach, S.; Demchuk, O. Fluorinated Cycloalkyl Building Blocks for Drug Discovery. ChemMedChem 2022, 17, e202200365. doi:10.1002/cmdc.202200365
- Poskin, T. J.; Piscelli, B. A.; Yoshida, K.; Cordes, D. B.; Slawin, A. M. Z.; Cormanich, R. A.; Yamada, S.; O'Hagan, D. Janus faced fluorocyclohexanes for supramolecular assembly: synthesis and solid state structures of equatorial mono-, di- and tri alkylated cyclohexanes and with tri-axial C-F bonds to impart polarity. Chemical communications (Cambridge, England) 2022, 58, 7968–7971. doi:10.1039/d2cc03010a
- Clark, J.; Neyyappadath, R. M.; Yu, C.; Slawin, A. M. Z.; Cordes, D. B.; O'Hagan, D. Janus All-Cis 2,3,4,5,6-Pentafluorocyclohexyl Building Blocks Applied to Medicinal Chemistry and Bioactives Discovery Chemistry. Chemistry (Weinheim an der Bergstrasse, Germany) 2021, 27, 16000–16005. doi:10.1002/chem.202102819
- Clark, J.; Taylor, A.; Geddis, A.; Neyyappadath, R. M.; Piscelli, B.; Yu, C.; Cordes, D. B.; Slawin, A. M. Z.; Cormanich, R. A.; Guldin, S.; O'Hagan, D. Supramolecular packing of alkyl substituted Janus face all-cis 2,3,4,5,6-pentafluorocyclohexyl motifs. Chemical science 2021, 12, 9712–9719. doi:10.1039/d1sc02130c
- Mondal, R.; Agbaria, M.; Nairoukh, Z. Fluorinated Rings: Conformation and Application. Chemistry (Weinheim an der Bergstrasse, Germany) 2021, 27, 7193–7213. doi:10.1002/chem.202005425
- O'Hagan, D. Polar Organofluorine Substituents: Multivicinal Fluorines on Alkyl Chains and Alicyclic Rings. Chemistry (Weinheim an der Bergstrasse, Germany) 2020, 26, 7981–7997. doi:10.1002/chem.202000178
- Bykova, T.; Al-Maharik, N.; Slawin, A. M. Z.; Bühl, M.; Lebl, T.; O'Hagan, D. Benzylic Functionalisation of Phenyl all-cis-2,3,5,6-Tetrafluorocyclohexane Provides Access to New Organofluorine Building Blocks. Chemistry (Weinheim an der Bergstrasse, Germany) 2018, 24, 13290–13296. doi:10.1002/chem.201802166
- Rodil, A.; Bosisio, S.; Ayoup, M. S.; Quinn, L.; Cordes, D. B.; Slawin, A. M. Z.; Murphy, C. D.; Michel, J.; O'Hagan, D. Metabolism and hydrophilicity of the polarised ‘Janus face’ all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery. Chemical science 2018, 9, 3023–3028. doi:10.1039/c8sc00299a
