Supporting Information
Supporting information contains full experimental and spectral data for thiolactone 5, the desired hybrids 3, tetracycles 4 and the general procedure for the synthesis of the N-alkylated 5-substituted isatin/isatin intermediates 6. The 1H NMR and 13C NMR spectra for compounds 3 and 4 are also included.
| Supporting Information File 1: Experimental procedures and spectral data for compounds 3–6 | ||
| Format: PDF | Size: 7.2 MB | Download |
| Supporting Information File 2: X-ray crystallography data for tetracycles 4a–c | ||
| Format: CIF | Size: 64.7 KB | Download |
Cite the Following Article
Novel tetracyclic structures from the synthesis of thiolactone-isatin hybrids
Renate Hazel Hans, Hong Su and Kelly Chibale
Beilstein J. Org. Chem. 2010, 6, No. 78.
https://doi.org/10.3762/bjoc.6.78
How to Cite
Hans, R. H.; Su, H.; Chibale, K. Beilstein J. Org. Chem. 2010, 6, No. 78. doi:10.3762/bjoc.6.78
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- Bogdanov, A. V.; Musin, L. I.; Il'in, A. V.; Mironov, V. F. Novel 1‐Aminomethylisatins: Peculiarities of the Synthesis and the Reaction with Tris(diethylamino)phosphine. Journal of Heterocyclic Chemistry 2013, 51, 1027–1030. doi:10.1002/jhet.2011
- Szostak, M.; Aubé, J. Chemistry of Bridged Lactams and Related Heterocycles. Chemical reviews 2013, 113, 5701–5765. doi:10.1021/cr4000144
- Brahmachari, A. O. G. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds: An Overview. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds; CRC Press, 2013; pp 23–30. doi:10.1201/b13867-5
- Hans, R. H.; Wiid, I.; van Helden, P. D.; Wan, B.; Franzblau, S. G.; Gut, J.; Rosenthal, P. J.; Chibale, K. Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents. Bioorganic & medicinal chemistry letters 2011, 21, 2055–2058. doi:10.1016/j.bmcl.2011.02.008
