Kinetic studies and predictions on the hydrolysis and aminolysis of esters of 2-S-phosphorylacetates

Milena Trmčić and David R. W. Hodgson
Beilstein J. Org. Chem. 2010, 6, 732–741. https://doi.org/10.3762/bjoc.6.87

Supporting Information

Supporting information features a PDF document presenting details of studies using the bromoacetyl-OBt system 1 (R = Bt) and bromoacetyl-NHS system 1 (R = NHS), and associated experimental details, as well as Excel™ spreadsheets for the prediction of product outcomes and the optimisation of leaving group pKaH values of 2-S-thiophosphate esters with reference to controlling aminolysis over hydrolysis.

Supporting Information File 1: Synthesis and application of bromoacetyl-OBt and NHS systems
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Supporting Information File 2: Prediction of product distribution using p-nitrophenyl ester 7 (R = pNP)
Format: XLS Size: 410.5 KB Download
Supporting Information File 3: Prediction of product distribution using m-nitrophenyl ester 7 (R = mNP)
Format: XLS Size: 408.5 KB Download
Supporting Information File 4: Optimisation of leaving group pKaH values of 2-S-thiophosphate esters
Format: XLS Size: 444.0 KB Download

Cite the Following Article

Kinetic studies and predictions on the hydrolysis and aminolysis of esters of 2-S-phosphorylacetates
Milena Trmčić and David R. W. Hodgson
Beilstein J. Org. Chem. 2010, 6, 732–741. https://doi.org/10.3762/bjoc.6.87

How to Cite

Trmčić, M.; Hodgson, D. R. W. Beilstein J. Org. Chem. 2010, 6, 732–741. doi:10.3762/bjoc.6.87

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