Synthesis in the glycosciences

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Editor: Prof. Thisbe K. Lindhorst
Christian-Albrechts-Universität zu Kiel
 
All cells are coated in carbohydrates and glycoconjugates. Today, after decades where sugars were regarded mainly as a means of energy storage or simply as molecular material, it is now known that carbohydrates are deeply involved in cellular communication. This awareness of the biological importance of carbohydrates has led to glycosciences becoming an intriguing and fascinating field of interdisciplinary research. However, the structural diversity found in the carbohydrate regime is unparalleled which makes the biological study of carbohydrate recognition and understanding the processes involved rather complicated. In addition, the multivalent nature of most carbohydrate ligands constitutes a special challenge in glycoscience.

See also the Thematic Series:
Synthesis in the glycosciences II
Multivalent glycosystems for nanoscience

See videos about glycoscience at Beilstein TV.

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Synthesis in the glycosciences

  • Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2010, 6, No. 16, doi:10.3762/bjoc.6.16

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Published 22 Feb 2010

Convergent syntheses of LeX analogues

  • An Wang,
  • Jenifer Hendel and
  • France-Isabelle Auzanneau

Beilstein J. Org. Chem. 2010, 6, No. 17, doi:10.3762/bjoc.6.17

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Published 22 Feb 2010
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Published 22 Feb 2010

Benzyne arylation of oxathiane glycosyl donors

  • Martin A. Fascione and
  • W. Bruce Turnbull

Beilstein J. Org. Chem. 2010, 6, No. 19, doi:10.3762/bjoc.6.19

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Preliminary Communication
Published 22 Feb 2010

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties

  • José L. Jiménez Blanco,
  • Fernando Ortega-Caballero,
  • Carmen Ortiz Mellet and
  • José M. García Fernández

Beilstein J. Org. Chem. 2010, 6, No. 20, doi:10.3762/bjoc.6.20

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Review
Published 22 Feb 2010

Synthesis of lipophilic 1-deoxygalactonojirimycin derivatives as D-galactosidase inhibitors

  • Georg Schitter,
  • Elisabeth Scheucher,
  • Andreas J. Steiner,
  • Arnold E. Stütz,
  • Martin Thonhofer,
  • Chris A. Tarling,
  • Stephen G. Withers,
  • Jacqueline Wicki,
  • Katrin Fantur,
  • Eduard Paschke,
  • Don J. Mahuran,
  • Brigitte A. Rigat,
  • Michael Tropak and
  • Tanja M. Wrodnigg

Beilstein J. Org. Chem. 2010, 6, No. 21, doi:10.3762/bjoc.6.21

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Published 01 Mar 2010

Bis(oxazolines) based on glycopyranosides – steric, configurational and conformational influences on stereoselectivity

  • Tobias Minuth and
  • Mike M. K. Boysen

Beilstein J. Org. Chem. 2010, 6, No. 23, doi:10.3762/bjoc.6.23

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Published 04 Mar 2010

Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid

  • Arne Homann,
  • Riaz-ul Qamar,
  • Sevnur Serim,
  • Petra Dersch and
  • Jürgen Seibel

Beilstein J. Org. Chem. 2010, 6, No. 24, doi:10.3762/bjoc.6.24

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Published 08 Mar 2010

Synthesis of glycosylated β3-homo-threonine conjugates for mucin-like glycopeptide antigen analogues

  • Florian Karch and
  • Anja Hoffmann-Röder

Beilstein J. Org. Chem. 2010, 6, No. 47, doi:10.3762/bjoc.6.47

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Published 12 May 2010

Preparation of aminoethyl glycosides for glycoconjugation

  • Robert Šardzík,
  • Gavin T. Noble,
  • Martin J. Weissenborn,
  • Andrew Martin,
  • Simon J. Webb and
  • Sabine L. Flitsch

Beilstein J. Org. Chem. 2010, 6, 699–703, doi:10.3762/bjoc.6.81

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Published 29 Jul 2010
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Published 26 Jul 2010

A bivalent glycopeptide to target two putative carbohydrate binding sites on FimH

  • Thisbe K. Lindhorst,
  • Kathrin Bruegge,
  • Andreas Fuchs and
  • Oliver Sperling

Beilstein J. Org. Chem. 2010, 6, 801–809, doi:10.3762/bjoc.6.90

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Published 24 Aug 2010

En route to photoaffinity labeling of the bacterial lectin FimH

  • Thisbe K. Lindhorst,
  • Michaela Märten,
  • Andreas Fuchs and
  • Stefan D. Knight

Beilstein J. Org. Chem. 2010, 6, 810–822, doi:10.3762/bjoc.6.91

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Published 26 Aug 2010

Design and synthesis of a cyclitol-derived scaffold with axial pyridyl appendages and its encapsulation of the silver(I) cation

  • Pierre-Marc Léo,
  • Christophe Morin and
  • Christian Philouze

Beilstein J. Org. Chem. 2010, 6, 1022–1024, doi:10.3762/bjoc.6.115

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Published 29 Oct 2010
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