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Synthesis in the glycosciences

Editor: Prof. Thisbe K. Lindhorst
Christian-Albrechts-Universität zu Kiel

All cells are coated in carbohydrates and glycoconjugates. Today, after decades where sugars were regarded mainly as a means of energy storage or simply as molecular material, it is now known that carbohydrates are deeply involved in cellular communication. This awareness of the biological importance of carbohydrates has led to glycosciences becoming an intriguing and fascinating field of interdisciplinary research. However, the structural diversity found in the carbohydrate regime is unparalleled which makes the biological study of carbohydrate recognition and understanding the processes involved rather complicated. In addition, the multivalent nature of most carbohydrate ligands constitutes a special challenge in glycoscience.

See also the Thematic Series:
Synthesis in the glycosciences II
Multivalent glycosystems for nanoscience

See videos about glycoscience at Beilstein TV.


Synthesis in the glycosciences

Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2010, 6, No. 16. published 22 Feb 2010


Convergent syntheses of LeX analogues

An Wang, Jenifer Hendel, France-Isabelle Auzanneau

Beilstein J. Org. Chem. 2010, 6, No. 17. published 22 Feb 2010

Full Research Paper

Benzyne arylation of oxathiane glycosyl donors

Martin A. Fascione, W. Bruce Turnbull

Beilstein J. Org. Chem. 2010, 6, No. 19. published 22 Feb 2010

Preliminary Communication

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties

José L. Jiménez Blanco, Fernando Ortega-Caballero, Carmen Ortiz Mellet, José M. García Fernández

Beilstein J. Org. Chem. 2010, 6, No. 20. published 22 Feb 2010


Synthesis of lipophilic 1-deoxygalactonojirimycin derivatives as D-galactosidase inhibitors

Georg Schitter, Elisabeth Scheucher, Andreas J. Steiner, Arnold E. Stütz, Martin Thonhofer, Chris A. Tarling, Stephen G. Withers, Jacqueline Wicki, Katrin Fantur, Eduard Paschke, Don J. Mahuran, Brigitte A. Rigat, Michael Tropak, Tanja M. Wrodnigg

Beilstein J. Org. Chem. 2010, 6, No. 21. published 01 Mar 2010

Full Research Paper

Bis(oxazolines) based on glycopyranosides – steric, configurational and conformational influences on stereoselectivity

Tobias Minuth, Mike M. K. Boysen

Beilstein J. Org. Chem. 2010, 6, No. 23. published 04 Mar 2010

Full Research Paper

Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid

Arne Homann, Riaz-ul Qamar, Sevnur Serim, Petra Dersch, Jürgen Seibel

Beilstein J. Org. Chem. 2010, 6, No. 24. published 08 Mar 2010

Full Research Paper

Synthesis of glycosylated β3-homo-threonine conjugates for mucin-like glycopeptide antigen analogues

Florian Karch, Anja Hoffmann-Röder

Beilstein J. Org. Chem. 2010, 6, No. 47. published 12 May 2010

Full Research Paper

Preparation of aminoethyl glycosides for glycoconjugation

Robert Šardzík, Gavin T. Noble, Martin J. Weissenborn, Andrew Martin, Simon J. Webb, Sabine L. Flitsch

Beilstein J. Org. Chem. 2010, 6, 699–703. published 29 Jul 2010

Full Research Paper

A bivalent glycopeptide to target two putative carbohydrate binding sites on FimH

Thisbe K. Lindhorst, Kathrin Bruegge, Andreas Fuchs, Oliver Sperling

Beilstein J. Org. Chem. 2010, 6, 801–809. published 24 Aug 2010

Full Research Paper

En route to photoaffinity labeling of the bacterial lectin FimH

Thisbe K. Lindhorst, Michaela Märten, Andreas Fuchs, Stefan D. Knight

Beilstein J. Org. Chem. 2010, 6, 810–822. published 26 Aug 2010

Full Research Paper

Design and synthesis of a cyclitol-derived scaffold with axial pyridyl appendages and its encapsulation of the silver(I) cation

Pierre-Marc Léo, Christophe Morin, Christian Philouze

Beilstein J. Org. Chem. 2010, 6, 1022–1024. published 29 Oct 2010