TY - JOUR A1 - Hornung, Christian H. A1 - Álvarez-Diéguez, Miguel Á. A1 - Kohl, Thomas M. A1 - Tsanaktsidis, John T1 - Diels–Alder reactions of myrcene using intensified continuous-flow reactors JF - Beilstein Journal of Organic Chemistry PY - 2017/// VL - 13 SP - 120 EP - 126 SN - 1860-5397 DO - 10.3762/bjoc.13.15 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.13.15 KW - continuous processing KW - flow chemistry KW - renewable feedstock KW - surfactant N2 - This work describes the Diels–Alder reaction of the naturally occurring substituted butadiene, myrcene, with a range of different naturally occurring and synthetic dienophiles. The synthesis of the Diels–Alder adduct from myrcene and acrylic acid, containing surfactant properties, was scaled-up in a plate-type continuous-flow reactor with a volume of 105 mL to a throughput of 2.79 kg of the final product per day. This continuous-flow approach provides a facile alternative scale-up route to conventional batch processing, and it helps to intensify the synthesis protocol by applying higher reaction temperatures and shorter reaction times. ER -