@Article{Lopez2008,
author="Susana S. Lopez and Gregory B. Dudley",
title="Convenient method for preparing benzyl ethers and esters using 2-benzyloxypyridine",
journal="Beilstein Journal of Organic Chemistry",
year="2008",
volume="4",
pages="44",
issn="1860-5397",
doi="10.3762/bjoc.4.44",
copyright="Lopez and Dudley; licensee Beilstein-Institut",
publisher="Beilstein-Institut",
URL="https://doi.org/10.3762/bjoc.4.44",
keywords="alcohols; alkylation; benzyl; electrophilic substitution; esters; ethers; protecting groups; reagent",
abstract="2-Benzyloxy-1-methylpyridinium triflate (1) is emerging as a mild, convenient, and in some cases uniquely effective new reagent for the synthesis of benzyl ethers and esters. This article provides a revised benzyl transfer protocol in which N-methylation of 2-benzyloxypyridine delivers the active reagent in situ. Observations on the appropriate choice of solvent (toluene vs. trifluorotoluene) and the extension of this methodology to the synthesis of other arylmethyl ethers are included.",
}