TY - JOUR A1 - Weichelt, Franziska A1 - Lenz, Solvig A1 - Tiede, Stefanie A1 - Reinhardt, Ingrid A1 - Frerich, Bernhard A1 - Buchmeiser, Michael R. T1 - ROMP-Derived cyclooctene-based monolithic polymeric materials reinforced with inorganic nanoparticles for applications in tissue engineering JF - Beilstein Journal of Organic Chemistry PY - 2010/// VL - 6 SP - 1199 EP - 1205 SN - 1860-5397 DO - 10.3762/bjoc.6.137 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.6.137 KW - hybrid materials KW - monoliths KW - nanoparticles KW - ring-opening metathesis polymerization (ROMP) KW - tissue engineering N2 - Porous monolithic inorganic/polymeric hybrid materials have been prepared via ring-opening metathesis copolymerization starting from a highly polar monomer, i.e., cis-5-cyclooctene-trans-1,2-diol and a 7-oxanorborn-2-ene-derived cross-linker in the presence of porogenic solvents and two types of inorganic nanoparticles (i.e., CaCO3 and calcium hydroxyapatite, respectively) using the third-generation Grubbs initiator RuCl2(Py)2(IMesH2)(CHPh). The physico-chemical properties of the monolithic materials, such as pore size distribution and microhardness were studied with regard to the nanoparticle type and content. Moreover, the reinforced monoliths were tested for the possible use as scaffold materials in tissue engineering, by carrying out cell cultivation experiments with human adipose tissue-derived stromal cells. ER -