School of Chemistry, University of Manchester, Oxford Rd., Manchester M13 9PL, United Kingdom bicyclic cyclisation dearomatisation enol ether heterocycle pyridine quinoline The silyl enol ether derivatives of ketones or esters tethered by a hydrocarbon or ether linkage to the 3-position of a pyridine ring undergo dearomatising nucleophilic attack on the ring once it is activated (as an acylpyridinium species) by the addition of methyl chloroformate. The bicyclic dihydropyridine products are in some cases unstable, but may be isolated after hydrogenation as fused bicyclic piperidines.

Oxidative or reductive (nucleophilic) dearomatising cyclisation reactions are effective strategies for rapidly building complexity and new reactivity from simple, readily made starting materials. We have used cyclisations of benzamide-stabilised carbanions, for example, to give bicyclic functionalised indolinones as intermediates in the synthesis of the neuroactive amino acids , while related cyclisations of pyridyl-, nicotinamide- and isonicotinamide-containing carbanions yield related bicyclic dihydropyridines . While reactive carbanions derived from allyl or benzyllithiums will undergo dearomatising addition even into relatively electron rich rings , the scope of the dearomatisation can be extended to much less reactive nucleophiles with a more electron deficient aromatic acceptor . Thus enolates of glycine esters 1 carrying isonicotinoyl or nicotinoyl N-substituents cyclise readily to yield bicyclic amino acid derivatives 2 ( for example) . Even greater reactivity towards intramolecular nucleophilic attack is exhibited by isonicotinamides when activated by N-sulfonation . For example, the N -furylmethyl isonicotinamide 3 cyclises to the doubly dearomatised bis-spirocycle 4 on treatment with triflic anhydride in the presence of an alcohol ( ). In this paper we report the results of cyclising the enolates of ester and ketones tethered to a nicotinyl nucleus via chains which do not incorporate an amide linkage. The starting materials for these cyclisations do not benefit from the favourable conformational disposition of amides 1 and 3 , making the reactions more challenging. Likewise, the products are evidently less stable than those produced by the reactions in , but nonetheless they allow new, partially saturated “drug-like” heterocyclic systems to be formed.

The study was initiated with the synthesis of the δ-nicotinyl ketone 7 as illustrated in . Ethyl benzoylacetate was alkylated with 3-(3-iodopropyl)pyridine 5 and the product 6 hydrolysed and decarboxylated to yield the pyridine 7 in moderate yield. On treatment of 7 with LDA in THF at −78 °C, followed by trapping with methyl chloroformate, a yield of 40% of the bicyclic hexahydroisoquinoline 8 was obtained ( ), which even after extensive experimentation could not be improved. Lack of crystallinity and overlapping 1 H NMR signals prevented us from confirming the relative stereochemistry, and the assignment shown in is on the basis that the benzoyl group of 8 is likely to lie on the exo face of the azadecalin system. We assume, in line with previous results , that cyclisation occurs only after the addition of the electrophilic trap (which, precedent suggests, attacks the pyridine lone pair and activates the ring as an acylpyridinium species even in the presence of the lithium enolate). Attempts to use bases with a sodium or potassium counter ion led instead to a high yield of the Claisen product 6 (R = Me), presumably because the sodium and potassium enolates are more reactive than the lithium enolate and compete too well with N-acylation. We surmised that effective cyclisation onto the acylpyridinium species, avoiding the N- vs. C-acylation problem, might be made possible by decreasing the reactivity of the enolate still further, transforming it into a silyl enol ether 9 . Silyl enol ethers and ketene acetals are known to add effectively to pyridinium species in an intermolecular manner . Thus 7 was converted to silyl enol ether 9 in excellent yield under standard conditions. A single geometrical isomer was obtained, presumably Z as shown. On treatment with methyl chloroformate, enol ether 9 cyclised to yield 8 again as a single diastereoisomer but in a greatly improved yield of 93%. The strategy of using a less nucleophilic specific enolate equivalent is clearly an effective way of improving selectivity, allowing the chloroformate to activate the pyridine without competing attack by the enolate. Next we extended the reaction to the cyclisation of a δ-nicotinyl butyrate ester 12 encouraged by the observations of Onaka , who demonstrated that silyl ketene acetals can be added (in an intermolecular fashion) to electron deficient pyridines in the presence of trimethylsilyl triflate, tetrabutylammonium fluoride or a montmorillonite clay. The cyclisation precursor was synthesised by using the procedure of Hayashi employing a Horner–Wadsworth–Emmons olefination between nicotinaldehyde and phosphonate 10 . The resulting mixture of dienes 11 gave ester 12 after hydrogenation ( ). It proved challenging to isolate cleanly the silyl ketene acetal derived from 12 , so instead we decided to form and cyclise the silyl derivative in a single pot. Thus, ester 12 was added to LDA at −78 °C, and the enolate quenched with trimethylsilyl chloride. After 15 min methyl chloroformate was added and the solution warmed to room temperature. Complete consumption of starting material (by TLC) was accompanied by the appearance of a single less polar spot ( R f 0.77; EtOAc–petroleum ether 1:1). 1 H NMR analysis of the crude product after rapid work-up showed two significant sets of new signals at 6.55–6.80 ppm (2H) and 4.65–5.10 ppm (1H) consistent with the dihydropyridine protons of the expected dearomatised product 14 ( ). However, in contrast with the clean spectra and dearomatised product 8 derived from ketone 7 , duplication of many of the signals in the crude 1 H NMR spectrum of 14 suggested the existence of either a mixture of diastereoisomers or rotamers caused by restricted rotation of the carbamate group. No dihydropyridine was isolable from this mixture by flash chromatography, probably due to rapid re-aromatisation. However, immediate hydrogenation at ambient pressure using the conditions developed by Arnott for related 3,4-fused dihydropyridines gave 15 in 45% yield after chromatography as an inseparable mixture of two diastereoisomers in a ratio of approximately 6:1. A slightly improved yield of 48% was obtained by the use of an H-cube flow hydrogenation apparatus at 40 bar and 30 °C. Unfortunately, again the lack of crystallinity and the large number of overlapping signals in the 1 H NMR spectrum frustrated an unequivocal assignment of the stereochemistry. However, hydrogenation of related fused dihydropyridines has always led to cis stereochemistry at the ring junction . The consequent expected axial–equatorial relationship between the protons at the ring junction is supported by a coupling constant of 4.2 Hz between these protons in 15 ( ) in the major product diastereoisomer. The corresponding 12.9 Hz coupling to the proton α to the ester group is consistent with adoption of an exo –equatorial orientation by this substituent.

Encouraged by the successful formation of carbocyclic rings in dearomatising cyclisations of nicotinyl ketones and esters, we moved to extend the reaction to the analogous formation of tetrahydofuranyl esters by cyclisation of starting materials incorporating an enolate nucleophile and a nicotinyl electrophile tethered through an ether linkage. Alkylation of 3-hydroxymethylpyridine by t -butyl bromoacetate 17a or bromopropionate 17b suffered from competing N-alkylation but returned acceptable yields of the esters 18a and 18b ( ). As with 13 , we anticipated that the silyl ketene acetal derivatives 19 would be challenging to isolate, so both starting esters 18a and 18b were treated with LDA and Me 3 SiCl followed by methyl chloroformate ( ). As with 14 , re-aromatisation was fast and the crude products 19 were therefore hydrogenated at atmospheric pressure to give 20a in up to 32% yield from 18a and 20b in up to 35% yield from 18b . The instability of the two non-isolable intermediates meant however that these yields were not consistently reproducible and yields around 25% were more commonly observed. However, scrupulous avoidance of contact with oxygen before the hydrogenation step improved the yield of 20a to 41%. Attempted cyclisation without formation of the silyl enol ether (i.e. omitting Me 3 SiCl) led to a complex mixture of products. In both cases the cyclic products were obtained as single diastereoisomers, indicating a diastereoselective cyclisation and a face-selective hydrogenation. An nOe experiment on cyclic ether 20b , irradiating the 7a ring junction proton, showed nOe enhancements of protons 3a, 6 (1H) and 7 (1H) ( ). This result is consistent with a cis -fused ring junction. A lack of conclusive nOes prevented determination of the stereochemistry at the ester-bearing centres of 20a or 20b . However, a similar cyclisation with an amide tether had resulted in an endo -orientated ester substituent, and the stereochemistries of 20 are accordingly shown with the ester orientated endo .

Tethered ketone or ester enolate nucleophiles undergo dearomatising attack on a pyridine ring to yield bicyclic products. Yields are greatest if the enolate is first stabilised as a silyl enol ether, presumably because acylation of the pyridine ring to give the electrophilic acylpyridinium species is cleaner. The bicyclic dihydropyridine products are unstable towards re-aromatisation, but can be isolated in moderate to excellent yield if they are hydrogenated in situ, especially when oxygen is excluded prior to and during the hydrogenation.

Methyl chloroformate (0.056 ml, 0.722 mmol) was added to a solution of 9 (45 mg, 0.144 mmol) and triethylamine (0.02 ml, 0.144 mmol) in dichloromethane (5 ml) at −78 °C. After warming to room temperature, dichloromethane was added (30 ml), and the solution washed with water (3 × 10 ml) and brine (10 ml). The combined aqueous layers were extracted with dichloromethane (10 ml) and the combined organic layers dried (Na 2 SO 4 ), filtered and concentrated under reduced pressure to furnish a light yellow oil. The oil was purified by flash column chromatography (SiO 2 ; petroleum ether–EtOAc 9:1) to yield the title compound as a colourless oil (40 mg, 0.135 mmol, 93%); silica gel TLC R f 0.38 (petroleum ether–EtOAc 4:1); IR (thin film) ν max (cm −1 ): 1721 (carbamate C=O), 1677 (ketone C=O); 1 H NMR (500 MHz, CDCl 3 , δ H ): 7.80 (2H, d, J = 7.5 Hz, Ph-H), 7.41 (1H, t, J = 8.0 Hz, Ph-H), 7.32 (2H, t, J = 8.0 Hz, Ph-H), 6.67 (1H, br, py-H 2 ), 6.54 (1H, br, py-H6), 4.60 (2H, br, py-H 5 ) 3.64 (3H, br, OCH 3 ), 3.33 (2H, m, py-H 4 and CH), 2.1–1.3 (6H, br-m, CH 2 ); 13 C NMR (125 MHz, CDCl 3 , δ C ): 202.9 (ketone C=O), 152.2 (carbamate C=O), 137.3, 133.6, 129.1 and 128.8 (aromatic), 123.4 and 123.0 (py-C 6 ), 120.9 and 119.9 (py-C 3 ), 117.1 and 116.8 (py-C 2 ), 108.1 and 107.7 (py-C 5 ), 60.8 (py-C 4 ), 53.8 and 53.7 (OCH 3 ), 38.0 and 37.8 (CH), 32.5 and 32.4 (CH 2 ), 31.7 and 31.6 (CH 2 ), 27.5 (CH 2 ); CIMS m/z (relative intensity): 298 (100%, M+H + ), 238 (40%, M-CO 2 Me); EIMS m/z (relative intensity): 297 (10%, M + ). [Found: M+H + , 298.1436. C 18 H 20 NO 3 requires 298.1438].

n -Butyllithium (0.36 mL of a 1.8 M solution in hexane) was added to a solution of diisopropylamine (0.11 mL, 0.75 mmol) in THF (15 mL) at 0 °C and the mixture stirred for 15 min before cooling to −78 °C. A solution of ester 12 (0.104 g, 0.5 mmol) in THF (5 mL) and then trimethylsilyl chloride (0.10 mL, 0.75 mmol) were added using a cannula. The solution was stirred at −78 °C for 15 min, methyl chloroformate (0.19 mL, 2.5 mmol) was added and the solution warmed to room temperature. The solution was rapidly added to a saturated sodium hydrogen carbonate solution (30 mL), extracted with EtOAc (2 × 30 mL), dried (MgSO 4 ), and concentrated to yield an oil. The crude oil was dissolved in isopropanol (6 mL), and 10% palladium/carbon (0.053 g, 0.05 mmol) was added and the suspension immediately placed under a hydrogen atmosphere. The suspension was warmed to 60 °C for 50 h, filtered through celite and evaporated under reduced pressure. The residue was purified by flash chromatography (SiO 2 ; EtOAc–petroleum ether 1:19 to 1:1) to yield the title compound (0.061 g, 45%) as a yellow oil which was approximately a 6:1 mixture of diastereoisomers; R f (EtOAc–petroleum ether 1:1) 0.45; IR (film) ν max (cm −1 ): 1730 (C=O ester), 1702 (C=O carbamate); 1 H NMR (300 MHz, CDCl 3 , δ H ): 3.95–4.25 (2H, m, 1-H and/or 3-H), 4.13 (2H, q, J = 7.5 Hz, C H 2 CH 3 ), 3.68 (3H, s, OMe maj ), 3.65 (OMe min ), 2.85–3.00 (1H, br m, 1-H or 3-H), 2.63–2.76 (1H, br, m, 1-H or 3-H), 2.49 (1H, dt, J = 13.0 Hz, 4.0, 5-H), 2.24 (1H, ap dq, J = 13.0 Hz, 4.0, CH), 1.83 (1H, dt, J = 12.5 Hz, 3.0, CH), 1.65–1.74 (3H, m, CH 2 ), 1.57 (1H, dd, J = 13.0 Hz, 3.5, CH 2 ), 1.37–1.51 (2H, m, CH 2 ), 1.17–1.35 (3H, m, CH 2 ), 1.25 (3H, t, J = 7.5 Hz, CH 2 C H 3 ); 13 C NMR (CDCl 3 , δ C ):174.6 (C=O), 156.7 (C=O), 60.5 (OCH 2 ), 52.8 (OMe), 49.9 (CH 2 ), 47.0 (COCH), 44.4 (NCH 2 ), 40.8 (CH), 37.1 (CH), 37.1 (CH min ), 30.0 (CH 2 ), 25.2 (CH 2 ), 24.5 (CH 2min ), 24.0 (CH 2 ), 22.1 (CH 2 ), 21.5 (CH 2min ), 14.6 (CH 2 C H 3 ); MS m/z (relative intensity): 270 (100%, MH + ); (Found: MH + , 270.1699. C 14 H 24 NO 4 requires MH + , 270.1700).

n -Butyllithium (0.34 mL of a 1.9 M solution in hexane) was added to a solution of diisopropylamine (0.11 mL, 0.75 mmol) in THF (10 mL) at 0 °C and stirred for 15 min before cooling to −78 °C. A solution of the ester 18a (0.112 g, 0.5 mmol) in THF (5 mL) was added using a cannula followed by trimethylsilyl chloride (0.10 mL, 0.75 mmol). The solution was then stirred at −78 °C for 45 min, methyl chloroformate (0.19 mL, 2.5 mmol) was added and the solution warmed to room temperature. The solution was rapidly worked-up under a nitrogen atmosphere by addition to saturated sodium hydrogen carbonate solution (30 mL) and extraction with EtOAc (15 mL). 10% Palladium on charcoal (0.053 g, 0.05 mmol) was added and the suspension immediately placed under a hydrogen atmosphere. The suspension was warmed to 45 °C for 18 h, filtered through Celite and evaporated under reduced pressure. The residue was purified by flash chromatography (SiO 2 ; EtOAc–petroleum ether 1:4 to 1:1) to yield the title compound (0.058 g, 41%) as white prisms; m.p. 49–51 °C (from Et 2 O); R f (EtOAc–petroleum ether 1:1) 0.23; IR (film) ν max (cm −1 ): 1745 (C=O ester), 1705 (C=O carbamate; 1 H NMR (300 MHz, CDCl 3 , δ H ): 4.37 (1H, d, J = 5.0 Hz, 1-H), 3.95–4.10 (2H, m, 4-H (1H) and 6-H (1H)), 3.98 (1H, t, J = 8.5 Hz, OC H a H b ), 3.79 (1H, t, J = 8.5 Hz, OCH a H b ), 3.67 (3H, s, OMe), 3.14–3.28 (1H, m, 4-H), 2.71–2.87 (1H, m, 6-H), 2.44–2.57 (2H, m, 3a-H and 7a-H), 1.50–1.58 (2H, m, 7-H), 1.47 (9H, s, (CH 3 ) 3 ); 13 C NMR (CDCl 3 , δ C ): 169.9 (C=O), 156.2 (C=O), 82.1( C (CH 3 ) 3 ), 81.3 (1-C), 69.2 (3-C), 52.9 (OMe), 42.6 (6-C), 41.7 (4-C), 39.6 (7a-C), 38.3 (3a-C), 28.4 ((CH 3 ) 3 ), 22.2 (7-C); MS m/z (relative intensity): 286 (15%, MH + ), 230 (100%, MH + −C(CH 3 ) 3 ); (Found: MH + , 286.1646. C 14 H 23 NO 5 requires MH + , 286.1649).

n -Butyllithium (0.34 mL of a 1.9 M solution in hexane) was added to a solution of diisopropylamine (0.11 mL, 0.75 mmol) in THF (15 mL) at 0 °C and stirred for 20 min before cooling to −78 °C. A solution of the ester 18b (0.098 g, 0.5 mmol) in THF (5 mL) was added using a cannula followed by trimethylsilyl chloride (0.10 mL, 0.75 mmol). The solution was then stirred at −78 °C for 15 min and methyl chloroformate (0.19 mL, 2.5 mmol) was added and the solution warmed to room temperature. The solution was rapidly worked-up by addition of saturated sodium hydrogen carbonate solution (30 mL), extracted with EtOAc (2 × 30 mL), dried (MgSO 4 ) and evaporated under reduced pressure. The residue was dissolved in propan-2-ol (7 mL), 10% palladium on charcoal (0.053 g, 0.05 mmol) was added and the suspension was immediately placed under a hydrogen atmosphere. The suspension was warmed to 50 °C for 24 h, filtered through celite, washed with EtOAc (5 × 10 mL) and evaporated under reduced pressure. The residue was purified by flash chromatography (SiO 2 ; EtOAc–petroleum ether 3:17 to 1:1) to yield the title compound (0.033 g, 35%) as a colourless oil; R f (EtOAc–petroleum ether 1:1) 0.25; IR (film) ν max (cm −1 ): 1752 (C=O ester), 1702 (C=O carbamate); 1 H NMR (300 MHz, CDCl 3 , δ H ): 4.07 (1H, t, J = 8.5 Hz, OC H a H b ), 3.81 (1H, t, J = 9.0 Hz, OCH a H b ), 3.75–4.02 (2H, m, 4-H and 6-H), 3.75 (3H, s, OMe), 3.24 (1H, br d, J = 12.5 Hz, 4-H or 6-H), 2.79 (1H, t, J = 12.0 Hz, 4-H or 6-H), 2.66 (1H, br s, 3a-H), 2.17–2.27 (1H, m, 7a-H), 1.49–1.64 (2H, m, 7-H), 1.46 (3H, s, (CH 3 ); 13 C NMR (CDCl 3 , δ C ): 174.0 (C=O ester), 156.4 (C=O carbamate), 87.5 (1-C), 69.1 (3-C), 53.0 (OMe), 52.4 (OMe), 45.1 (7a-C), 42.6 (6-C), 41.8 (4-C), 36.9 (3a-C), 25.1 (C C H 3 ), 23.6 (7-C); MS m/z (relative intensity): 258 (100%, MH + ), 275 (55%, MNH 4 + ); (Found: MH + , 258.1340. C 12 H 19 NO 5 requires MH + , 258.1336).

Coupling constants (Hz) in the major diastereoisomer of 15 .

Determination of the stereochemistry of 20b . Arrows indicate nuclear Overhauser enhancements.

Dearomatising cyclisations (a) of enolates; (b) of electron-rich heteroaromatics. Synthesis of ketone 7 . Dearomatising cyclisation to a 5-benzoylhexahydroisoquinoline. Synthesis of ester 12 . Dearomatising cyclisation of ester 12 . Synthesis of esters 18 . Dearomatising cyclisation to form tetrahydrofurans. PMZNWXCKNZMHMC-UHFFFAOYSA-N InChI=1S/C18H16N2O2/c21-18(16-8-10-19-11-9-16)20(14-17-7-4-12-22-17)13-15-5-2-1-3-6-15/h1-12H,13-14H2 C1=CC=C(C=C1)CN(CC2=CC=CO2)C(=O)C3=CC=NC=C3 C1=CN=CC=C1C(=O)N(CC2=CC=CC=C2)CC=3OC=CC3 |(8.87,-91.7,;3.09,-101.65,;8.82,-111.62,;20.32,-111.65,;26.09,-101.71,;20.37,-91.74,;26.15,-81.79,;20.43,-71.82,;37.65,-81.82,;43.43,-71.88,;54.93,-71.91,;60.65,-81.89,;72.15,-81.92,;77.93,-71.98,;72.2,-62,;60.7,-61.97,;43.37,-91.8,;54.87,-91.83,;62.98,-99.99,;73.24,-94.79,;72.32,-83.92,;60.64,-81.9,)| AuxInfo=1/0/N:13,12,14,21,11,15,22,1,5,2,4,20,16,17,10,6,18,7,3,9,8,19/E:(2,3)(5,6)(8,9)(10,11)/rA:22nCCNCCCCONCCCCCCCCCOCCC/rB:d1;s2;d3;s4;s1d5;s6;d7;s7;;d10;s11;d12;s13;s10d14;s9s10;s9;s17;s18;s19;d20;d18s21;/rC:8,8710,-91,7034,0;3,0931,-101,6466,0;8,8151,-111,6219,0;20,3151,-111,6542,0;26,0930,-101,7111,0;20,3710,-91,7357,0;26,1489,-81,7926,0;20,4268,-71,8172,0;37,6488,-81,8248,0;54,9267,-71,9139,0;60,6487,-81,8893,0;72,1487,-81,9216,0;77,9266,-71,9784,0;72,2045,-62,0031,0;60,7046,-61,9708,0;43,4267,-71,8817,0;43,3709,-91,8002,0;54,8708,-91,8325,0;62,9797,-99,9870,0;73,2409,-94,7948,0;72,3158,-83,9207,0;60,6408,-81,9030,0; C18H16N2O2 C1=CC=C(C=C1)C* Bn CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 22 24 0 0 0 M V30 BEGIN ATOM M V30 1 C 8.87102 -91.70345 0 0 M V30 2 C 3.09309 -101.64658 0 0 M V30 3 N 8.81514 -111.62195 0 0 M V30 4 C 20.31509 -111.65421 0 0 M V30 5 C 26.093 -101.71107 0 0 M V30 6 C 20.37097 -91.7357 0 0 M V30 7 C 26.14888 -81.79257 0 0 M V30 8 O 20.42683 -71.8172 0 0 M V30 9 N 37.64883 -81.82483 0 0 M V30 10 C 54.9267 -71.91394 0 0 M V30 11 C 60.64874 -81.88931 0 0 M V30 12 C 72.1487 -81.92157 0 0 M V30 13 C 77.92661 -71.97844 0 0 M V30 14 C 72.20454 -62.00307 0 0 M V30 15 C 60.70459 -61.97081 0 0 M V30 16 C 43.42674 -71.8817 0 0 M V30 17 C 43.37086 -91.80022 0 0 M V30 18 C 54.87082 -91.83246 0 0 M V30 19 O 62.97972 -99.98697 0 0 M V30 20 C 73.24091 -94.79483 0 0 M V30 21 C 72.31577 -83.9207 0 0 M V30 22 C 60.64082 -81.90295 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 6 7 M V30 8 2 7 8 M V30 9 1 7 9 M V30 10 2 10 11 M V30 11 1 11 12 M V30 12 2 12 13 M V30 13 1 13 14 M V30 14 2 14 15 M V30 15 1 10 15 M V30 16 1 10 16 M V30 17 1 9 16 M V30 18 1 9 17 M V30 19 1 17 18 M V30 20 1 18 19 M V30 21 1 19 20 M V30 22 2 20 21 M V30 23 1 21 22 M V30 24 2 22 18 M V30 END BOND M V30 END CTAB M END GKKZMYDNDDMXSE-UHFFFAOYSA-N InChI=1S/C11H12O3/c1-2-14-11(13)8-10(12)9-6-4-3-5-7-9/h3-7H,2,8H2,1H3 CCOC(=O)CC(=O)C1=CC=CC=C1 C(CC(OCC)=O)(=O)C1=CC=CC=C1 |(89.86,-15.4,;99.78,-21.13,;109.71,-15.4,;119.63,-15.4,;129.56,-21.13,;139.48,-15.4,;109.71,-3.9,;89.86,-3.94,;79.9,-21.15,;69.94,-15.4,;59.98,-21.15,;59.98,-32.65,;69.94,-38.4,;79.9,-32.65,)| AuxInfo=1/0/N:5,6,12,11,13,10,14,2,9,1,3,7,8,4/E:(4,5)(6,7)/rA:14nCCCOCCOOCCCCCC/rB:s1;s2;s3;;s4s5;d1;d3;s1;d9;s10;d11;s12;s9d13;/rC:89,8601,-15,4000,0;99,7848,-21,1300,0;109,7095,-15,4000,0;119,6342,-15,4000,0;139,4837,-15,4000,0;129,5590,-21,1300,0;89,8601,-3,9399,0;109,7095,-3,9000,0;79,9008,-21,1500,0;69,9415,-15,3999,0;59,9822,-21,1499,0;59,9822,-32,6499,0;69,9415,-38,3999,0;79,9008,-32,6500,0; C11H12O3 C1=CC=C(C=C1)* Ph,CCO* OEt CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 14 14 0 0 0 M V30 BEGIN ATOM M V30 1 C 89.86009 -15.39999 0 0 M V30 2 C 99.78481 -21.13004 0 0 M V30 3 C 109.70952 -15.39999 0 0 M V30 4 O 119.63425 -15.39999 0 0 M V30 5 C 139.48367 -15.39999 0 0 M V30 6 C 129.55896 -21.13004 0 0 M V30 7 O 89.86009 -3.93993 0 0 M V30 8 O 109.70952 -3.89999 0 0 M V30 9 C 79.90079 -21.14998 0 0 M V30 10 C 69.9415 -15.39995 0 0 M V30 11 C 59.98219 -21.14993 0 0 M V30 12 C 59.98218 -32.64993 0 0 M V30 13 C 69.94145 -38.39995 0 0 M V30 14 C 79.90076 -32.64996 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 1 2 3 M V30 3 1 4 6 M V30 4 1 5 6 M V30 5 1 3 4 M V30 6 2 1 7 M V30 7 2 3 8 M V30 8 2 9 10 M V30 9 1 10 11 M V30 10 2 11 12 M V30 11 1 12 13 M V30 12 2 13 14 M V30 13 1 9 14 M V30 14 1 1 9 M V30 END BOND M V30 END CTAB M END RRHCJOYHFBDDPM-UHFFFAOYSA-N InChI=1S/C16H17NO/c18-16(15-9-2-1-3-10-15)11-5-4-7-14-8-6-12-17-13-14/h1-3,6,8-10,12-13H,4-5,7,11H2 C1=CC=C(C=C1)C(=O)CCCCC2=CC=CN=C2 N1=CC=CC(=C1)CCCCC(C2=CC=CC=C2)=O |(60.35,-77.8,;60.35,-89.3,;70.31,-95.05,;80.27,-89.3,;80.27,-77.8,;70.31,-72.05,;90.23,-72.05,;100.19,-77.8,;110.15,-72.05,;120.11,-77.8,;130.07,-72.05,;140.02,-77.8,;140.02,-89.3,;149.98,-95.05,;159.94,-89.3,;159.94,-77.8,;149.98,-72.05,;130.07,-60.55,)| AuxInfo=1/0/N:15,14,16,8,9,3,7,4,13,17,10,2,6,5,12,11,1,18/E:(2,3)(9,10)/rA:18nNCCCCCCCCCCCCCCCCO/rB:d1;s2;d3;s4;s1d5;s5;s7;s8;s9;s10;s11;d12;s13;d14;s15;s12d16;d11;/rC:60,3500,-77,7995,0;60,3500,-89,2995,0;70,3093,-95,0495,0;80,2686,-89,2995,0;80,2686,-77,7995,0;70,3093,-72,0495,0;90,2279,-72,0495,0;100,1871,-77,7995,0;110,1464,-72,0495,0;120,1057,-77,7995,0;130,0650,-72,0495,0;140,0243,-77,7995,0;140,0243,-89,2995,0;149,9836,-95,0495,0;159,9429,-89,2995,0;159,9429,-77,7995,0;149,9836,-72,0495,0;130,0650,-60,5495,0; C16H17NO C1=CC=C(C=C1)* Ph CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 18 19 0 0 0 M V30 BEGIN ATOM M V30 1 N 60.34999 -77.79955 0 0 M V30 2 C 60.34999 -89.29955 0 0 M V30 3 C 70.30927 -95.04955 0 0 M V30 4 C 80.26857 -89.29955 0 0 M V30 5 C 80.26857 -77.79955 0 0 M V30 6 C 70.30927 -72.04955 0 0 M V30 7 C 90.22786 -72.04955 0 0 M V30 8 C 100.18715 -77.79955 0 0 M V30 9 C 110.14644 -72.04955 0 0 M V30 10 C 120.10573 -77.79955 0 0 M V30 11 C 130.06502 -72.04955 0 0 M V30 12 C 140.02431 -77.79953 0 0 M V30 13 C 140.02429 -89.29953 0 0 M V30 14 C 149.9836 -95.04955 0 0 M V30 15 C 159.94289 -89.29955 0 0 M V30 16 C 159.94289 -77.79955 0 0 M V30 17 C 149.9836 -72.04955 0 0 M V30 18 O 130.06502 -60.54955 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 8 M V30 9 1 8 9 M V30 10 1 9 10 M V30 11 1 10 11 M V30 12 2 12 13 M V30 13 1 13 14 M V30 14 2 14 15 M V30 15 1 15 16 M V30 16 2 16 17 M V30 17 1 12 17 M V30 18 1 11 12 M V30 19 2 11 18 M V30 END BOND M V30 END CTAB M END WDSKLPKCQAOHBK-UHFFFAOYSA-N InChI=1S/C8H10IN/c9-5-1-3-8-4-2-6-10-7-8/h2,4,6-7H,1,3,5H2 C(CC1=CC=CN=C1)CI N1=CC=CC(=C1)CCCI |(2.85,-28.8,;2.85,-40.3,;12.81,-46.05,;22.77,-40.3,;22.77,-28.8,;12.81,-23.05,;32.73,-23.05,;42.69,-28.8,;52.65,-23.05,;62.61,-28.8,)| AuxInfo=1/0/N:8,3,7,4,9,2,6,5,10,1/rA:10nNCCCCCCCCI/rB:d1;s2;d3;s4;s1d5;s5;s7;s8;s9;/rC:2,8500,-28,7995,0;2,8500,-40,2995,0;12,8093,-46,0495,0;22,7686,-40,2995,0;22,7686,-28,7995,0;12,8093,-23,0495,0;32,7279,-23,0495,0;42,6871,-28,7995,0;52,6464,-23,0495,0;62,6057,-28,7995,0; C8H10IN CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 10 10 0 0 0 M V30 BEGIN ATOM M V30 1 N 2.84999 -28.79955 0 0 M V30 2 C 2.84999 -40.29955 0 0 M V30 3 C 12.80927 -46.04955 0 0 M V30 4 C 22.76857 -40.29955 0 0 M V30 5 C 22.76857 -28.79955 0 0 M V30 6 C 12.80927 -23.04955 0 0 M V30 7 C 32.72786 -23.04955 0 0 M V30 8 C 42.68715 -28.79955 0 0 M V30 9 C 52.64644 -23.04955 0 0 M V30 10 I 62.60573 -28.79955 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 8 M V30 9 1 8 9 M V30 10 1 9 10 M V30 END BOND M V30 END CTAB M END KKSQLYWIGONXON-HZPDHXFCSA-N InChI=1S/C18H19NO3/c1-22-18(21)19-11-10-15-14(12-19)8-5-9-16(15)17(20)13-6-3-2-4-7-13/h2-4,6-7,10-12,15-16H,5,8-9H2,1H3/t15-,16-/m1/s1 COC(=O)N1C=C[C@]2([H])C(=C1)CCC[C@H]2C(=O)C3=CC=CC=C3 N1(C=C[C@@]2(C(=C1)CCC[C@H]2C(=O)C3=CC=CC=C3)[H])C(OC)=O |(185.99,-21.18,;185.99,-32.68,;195.95,-38.43,;205.91,-32.68,;205.91,-21.18,;195.95,-15.43,;215.87,-15.43,;225.83,-21.18,;225.83,-32.68,;215.87,-38.43,;215.87,-49.93,;205.91,-55.68,;225.83,-55.68,;225.83,-67.18,;235.79,-72.93,;245.75,-67.18,;245.75,-55.68,;235.79,-49.93,;205.91,-44.18,;176.04,-15.43,;166.08,-21.18,;166.08,-32.68,;176.04,-3.93,)| AuxInfo=1/0/N:9,21,20,22,13,19,23,14,12,3,2,6,18,5,4,11,15,7,1,17,10,8/E:(3,4)(6,7)/it:im/rA:23nNCCC.oCCCOCOC.oCCCCHOCCCCCC/rB:s1;d2;s3;s4;s1d5;s1;s7;s8;d7;s4;s11;s12;s5s13;P11;P4;d15;s15;d18;s19;d20;s21;s18d22;/rC:185,9949,-21,1833,0;185,9949,-32,6833,0;195,9542,-38,4333,0;205,9135,-32,6833,0;205,9135,-21,1833,0;195,9542,-15,4333,0;176,0356,-15,4333,0;166,0763,-21,1833,0;166,0763,-32,6833,0;176,0356,-3,9333,0;215,8728,-38,4333,0;225,8320,-32,6833,0;225,8320,-21,1833,0;215,8728,-15,4333,0;215,8728,-49,9333,0;205,9135,-44,1833,0;205,9135,-55,6833,0;225,8320,-55,6833,0;225,8320,-67,1833,0;235,7913,-72,9333,0;245,7506,-67,1833,0;245,7506,-55,6833,0;235,7913,-49,9333,0; C18H19NO3 C1=CC=C(C=C1)* Ph,CO* OMe CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 23 25 0 0 1 M V30 BEGIN ATOM M V30 1 N 185.99489 -21.18332 0 0 M V30 2 C 185.99489 -32.68332 0 0 M V30 3 C 195.95416 -38.43332 0 0 M V30 4 C 205.91347 -32.68332 0 0 CFG=1 M V30 5 C 205.91347 -21.18332 0 0 M V30 6 C 195.95416 -15.43332 0 0 M V30 7 C 176.03558 -15.43332 0 0 M V30 8 O 166.07629 -21.18332 0 0 M V30 9 C 166.07629 -32.68332 0 0 M V30 10 O 176.03558 -3.93332 0 0 M V30 11 C 215.87276 -38.43332 0 0 CFG=2 M V30 12 C 225.83205 -32.68332 0 0 M V30 13 C 225.83205 -21.18332 0 0 M V30 14 C 215.87276 -15.43332 0 0 M V30 15 C 215.87276 -49.93332 0 0 M V30 16 O 205.91347 -55.68332 0 0 M V30 17 C 225.83205 -55.68332 0 0 M V30 18 C 225.83203 -67.1833 0 0 M V30 19 C 235.79134 -72.93332 0 0 M V30 20 C 245.75063 -67.18332 0 0 M V30 21 C 245.75063 -55.68332 0 0 M V30 22 C 235.79134 -49.93332 0 0 M V30 23 H 205.91347 -44.18332 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 2 2 3 M V30 3 1 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 1 7 M V30 8 1 8 9 M V30 9 1 7 8 M V30 10 2 7 10 M V30 11 1 4 11 M V30 12 1 11 12 M V30 13 1 12 13 M V30 14 1 13 14 M V30 15 1 14 5 M V30 16 1 11 15 CFG=1 M V30 17 1 4 23 CFG=1 M V30 18 2 15 16 M V30 19 2 17 18 M V30 20 1 18 19 M V30 21 2 19 20 M V30 22 1 20 21 M V30 23 2 21 22 M V30 24 1 17 22 M V30 25 1 15 17 M V30 END BOND M V30 END CTAB M END XAOSWYIQXSXXED-RGEXLXHISA-N InChI=1S/C19H25NOSi/c1-22(2,3)21-19(18-12-5-4-6-13-18)14-8-7-10-17-11-9-15-20-16-17/h4-6,9,11-16H,7-8,10H2,1-3H3/b19-14- C[Si](C)(C)O/C(=C\CCCC1=CC=CN=C1)/C2=CC=CC=C2 N1=CC=CC(=C1)CCCC=C(C2=CC=CC=C2)O[Si](C)(C)C |(66.49,-103.43,;66.49,-114.93,;76.45,-120.68,;86.41,-114.93,;86.41,-103.43,;76.45,-97.68,;96.37,-97.68,;106.33,-103.43,;116.29,-97.68,;126.25,-103.43,;136.21,-97.68,;146.17,-103.43,;146.17,-114.93,;156.13,-120.68,;166.09,-114.93,;166.09,-103.43,;156.13,-97.68,;136.21,-86.18,;126.25,-80.43,;116.29,-74.68,;116.29,-86.18,;126.25,-68.93,)| AuxInfo=1/0/N:20,21,22,15,14,16,8,9,3,7,4,13,17,10,2,6,5,12,11,1,18,19/E:(1,2,3)(5,6)(12,13)/rA:22nNCCCCCCCCCCCCCCCCOSiCCC/rB:d1;s2;d3;s4;s1d5;s5;s7;s8;s9;d+10;s11;d12;s13;d14;s15;s12d16;s11;s18;s19;s19;s19;/rC:66,4949,-103,4333,0;66,4949,-114,9333,0;76,4542,-120,6833,0;86,4135,-114,9333,0;86,4135,-103,4333,0;76,4542,-97,6833,0;96,3728,-97,6833,0;106,3320,-103,4333,0;116,2913,-97,6833,0;126,2506,-103,4333,0;136,2099,-97,6833,0;146,1692,-103,4333,0;146,1692,-114,9333,0;156,1285,-120,6833,0;166,0878,-114,9333,0;166,0878,-103,4333,0;156,1285,-97,6833,0;136,2099,-86,1833,0;126,2506,-80,4333,0;116,2913,-74,6833,0;116,2913,-86,1833,0;126,2506,-68,9333,0; C19H25NOSi C1=CC=C(C=C1)* Ph,C[Si](C)(C)O* OSiMe3 CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 22 23 0 0 0 M V30 BEGIN ATOM M V30 1 N 66.49489 -103.43332 0 0 M V30 2 C 66.49489 -114.93332 0 0 M V30 3 C 76.45416 -120.68332 0 0 M V30 4 C 86.41347 -114.93332 0 0 M V30 5 C 86.41347 -103.43332 0 0 M V30 6 C 76.45416 -97.68332 0 0 M V30 7 C 96.37276 -97.68332 0 0 M V30 8 C 106.33205 -103.43332 0 0 M V30 9 C 116.29134 -97.68332 0 0 M V30 10 C 126.25063 -103.43332 0 0 M V30 11 C 136.20992 -97.68332 0 0 M V30 12 C 146.1692 -103.4333 0 0 M V30 13 C 146.16919 -114.9333 0 0 M V30 14 C 156.12849 -120.68332 0 0 M V30 15 C 166.08778 -114.93332 0 0 M V30 16 C 166.08778 -103.43332 0 0 M V30 17 C 156.12849 -97.68332 0 0 M V30 18 O 136.20992 -86.18332 0 0 M V30 19 Si 126.25061 -80.43332 0 0 M V30 20 C 116.29132 -74.68332 0 0 M V30 21 C 116.29132 -86.18332 0 0 M V30 22 C 126.25061 -68.93332 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 8 M V30 9 1 8 9 M V30 10 1 9 10 M V30 11 2 10 11 M V30 12 2 12 13 M V30 13 1 13 14 M V30 14 2 14 15 M V30 15 1 15 16 M V30 16 2 16 17 M V30 17 1 12 17 M V30 18 1 11 12 M V30 19 1 18 19 M V30 20 1 19 20 M V30 21 1 19 21 M V30 22 1 19 22 M V30 23 1 11 18 M V30 END BOND M V30 END CTAB M END GSZCCOFBHJPXPT-UHFFFAOYSA-N InChI=1S/C12H17NO2/c1-2-15-12(14)8-4-3-6-11-7-5-9-13-10-11/h5,7,9-10H,2-4,6,8H2,1H3 CCOC(=O)CCCCC1=CC=CN=C1 N1=CC=CC(=C1)CCCCC(OCC)=O |(151.85,-76.18,;151.85,-87.68,;161.81,-93.43,;171.77,-87.68,;171.77,-76.18,;161.81,-70.43,;181.73,-70.43,;191.69,-76.18,;201.65,-70.43,;211.61,-76.18,;221.57,-70.43,;231.52,-76.18,;241.48,-70.43,;251.44,-76.18,;221.57,-58.93,)| AuxInfo=1/0/N:13,14,8,9,3,7,4,10,2,6,5,11,1,15,12/rA:15nNCCCCCCCCCCOCCO/rB:d1;s2;d3;s4;s1d5;s5;s7;s8;s9;s10;s11;;s12s13;d11;/rC:151,8500,-76,1833,0;151,8500,-87,6833,0;161,8093,-93,4333,0;171,7686,-87,6833,0;171,7686,-76,1833,0;161,8093,-70,4333,0;181,7279,-70,4333,0;191,6871,-76,1833,0;201,6464,-70,4333,0;211,6057,-76,1833,0;221,5650,-70,4333,0;231,5243,-76,1833,0;251,4429,-76,1833,0;241,4836,-70,4333,0;221,5650,-58,9333,0; C12H17NO2 CCO* OEt CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 15 15 0 0 0 M V30 BEGIN ATOM M V30 1 N 151.84999 -76.18332 0 0 M V30 2 C 151.84999 -87.68332 0 0 M V30 3 C 161.80927 -93.43332 0 0 M V30 4 C 171.76857 -87.68332 0 0 M V30 5 C 171.76857 -76.18332 0 0 M V30 6 C 161.80927 -70.43332 0 0 M V30 7 C 181.72786 -70.43332 0 0 M V30 8 C 191.68715 -76.18332 0 0 M V30 9 C 201.64644 -70.43332 0 0 M V30 10 C 211.60573 -76.18332 0 0 M V30 11 C 221.56502 -70.43332 0 0 M V30 12 O 231.52431 -76.18332 0 0 M V30 13 C 251.44289 -76.18333 0 0 M V30 14 C 241.4836 -70.43333 0 0 M V30 15 O 221.56502 -58.93332 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 8 M V30 9 1 8 9 M V30 10 1 9 10 M V30 11 1 10 11 M V30 12 1 12 14 M V30 13 1 13 14 M V30 14 1 11 12 M V30 15 2 11 15 M V30 END BOND M V30 END CTAB M END LXLODBXSCRTXFG-BQYQJAHWSA-N InChI=1S/C10H19O5P/c1-4-13-10(11)8-7-9-16(12,14-5-2)15-6-3/h7-8H,4-6,9H2,1-3H3/b8-7+ CCOC(=O)/C=C/CP(=O)(OCC)OCC P(=O)(OCC)(OCC)CC=CC(OCC)=O |(33.73,-15.43,;23.77,-9.68,;33.73,-26.93,;23.77,-32.68,;23.77,-44.18,;43.69,-9.68,;43.69,1.82,;53.65,7.57,;43.69,-21.18,;53.65,-15.43,;63.61,-21.18,;73.57,-15.43,;83.52,-21.18,;93.48,-15.43,;103.44,-21.18,;73.57,-3.93,)| AuxInfo=1/0/N:14,4,7,15,5,8,10,11,9,12,16,2,13,3,6,1/E:(2,3)(5,6)(14,15)/rA:16nPOOCCOCCCCCCOCCO/rB:d1;s1;;s3s4;s1;;s6s7;s1;s9;d+10;s11;s12;;s13s14;d12;/rC:33,7279,-15,4333,0;23,7686,-9,6833,0;33,7278,-26,9333,0;23,7686,-44,1833,0;23,7686,-32,6833,0;43,6871,-9,6833,0;53,6464,7,5667,0;43,6871,1,8167,0;43,6871,-21,1833,0;53,6464,-15,4333,0;63,6057,-21,1833,0;73,5650,-15,4333,0;83,5243,-21,1833,0;103,4429,-21,1833,0;93,4836,-15,4333,0;73,5650,-3,9333,0; C10H19O5P CCO* OEt,CCOP(=O)(OCC)* PO(OEt)2 CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 16 15 0 0 0 M V30 BEGIN ATOM M V30 1 P 33.72786 -15.43332 0 0 M V30 2 O 23.76855 -9.6833 0 0 M V30 3 O 33.72784 -26.9333 0 0 M V30 4 C 23.76855 -44.1833 0 0 M V30 5 C 23.76855 -32.6833 0 0 M V30 6 O 43.68715 -9.68332 0 0 M V30 7 C 53.64644 7.56667 0 0 M V30 8 C 43.68715 1.81667 0 0 M V30 9 C 43.68715 -21.18332 0 0 M V30 10 C 53.64644 -15.43332 0 0 M V30 11 C 63.60573 -21.18332 0 0 M V30 12 C 73.56502 -15.43332 0 0 M V30 13 O 83.52431 -21.18332 0 0 M V30 14 C 103.44289 -21.18333 0 0 M V30 15 C 93.4836 -15.43333 0 0 M V30 16 O 73.56502 -3.93332 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 1 3 M V30 3 1 1 6 M V30 4 1 3 5 M V30 5 1 4 5 M V30 6 1 6 8 M V30 7 1 7 8 M V30 8 1 1 9 M V30 9 1 9 10 M V30 10 2 10 11 M V30 11 1 11 12 M V30 12 1 13 15 M V30 13 1 14 15 M V30 14 1 12 13 M V30 15 2 12 16 M V30 END BOND M V30 END CTAB M END QJZUKDFHGGYHMC-UHFFFAOYSA-N InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H C1=CN=CC(=C1)C=O N1=CC=CC(=C1)C=O |(121.85,-31.68,;121.85,-43.18,;131.81,-48.93,;141.77,-43.18,;141.77,-31.68,;131.81,-25.93,;151.73,-25.93,;161.69,-31.68,)| AuxInfo=1/0/N:3,4,2,6,7,5,1,8/rA:8nNCCCCCCO/rB:d1;s2;d3;s4;s1d5;s5;d7;/rC:121,8500,-31,6833,0;121,8500,-43,1833,0;131,8093,-48,9333,0;141,7686,-43,1833,0;141,7686,-31,6833,0;131,8093,-25,9333,0;151,7279,-25,9333,0;161,6871,-31,6833,0; C6H5NO C(=O)* CHO CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 8 8 0 0 0 M V30 BEGIN ATOM M V30 1 N 121.84999 -31.68332 0 0 M V30 2 C 121.84999 -43.18332 0 0 M V30 3 C 131.80927 -48.93332 0 0 M V30 4 C 141.76857 -43.18332 0 0 M V30 5 C 141.76857 -31.68332 0 0 M V30 6 C 131.80927 -25.93332 0 0 M V30 7 C 151.72786 -25.93332 0 0 M V30 8 O 161.68715 -31.6833 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 2 7 8 M V30 8 1 5 7 M V30 END BOND M V30 END CTAB M END WGSMUXGSKWSTAD-BARCQMOHSA-N InChI=1S/C12H13NO2/c1-2-15-12(14)8-4-3-6-11-7-5-9-13-10-11/h3-10H,2H2,1H3/b6-3?,8-4+ CCOC(=O)C=CC=CC1=CC=CN=C1 N1=CC=CC(=C1)C=CC=CC(OCC)=O |(2.85,-76.18,;2.85,-87.68,;12.81,-93.43,;22.77,-87.68,;22.77,-76.18,;12.81,-70.43,;32.73,-70.43,;42.69,-76.18,;52.65,-70.43,;62.61,-76.18,;72.57,-70.43,;82.52,-76.18,;92.48,-70.43,;102.44,-76.18,;72.57,-58.93,)| AuxInfo=1/0/N:13,14,8,9,3,7,4,10,2,6,5,11,1,15,12/rA:15nNCCCCCCCCCCOCCO/rB:d1;s2;d3;s4;s1d5;s5;d7;V8;d9;s10;s11;;s12s13;d11;/rC:2,8500,-76,1833,0;2,8500,-87,6833,0;12,8093,-93,4333,0;22,7686,-87,6833,0;22,7686,-76,1833,0;12,8093,-70,4333,0;32,7279,-70,4333,0;42,6871,-76,1833,0;52,6464,-70,4333,0;62,6057,-76,1833,0;72,5650,-70,4333,0;82,5243,-76,1833,0;102,4429,-76,1833,0;92,4836,-70,4333,0;72,5650,-58,9333,0; C12H13NO2 CCO* OEt CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 15 15 0 0 0 M V30 BEGIN ATOM M V30 1 N 2.84999 -76.18332 0 0 M V30 2 C 2.84999 -87.68332 0 0 M V30 3 C 12.80927 -93.43332 0 0 M V30 4 C 22.76857 -87.68332 0 0 M V30 5 C 22.76857 -76.18332 0 0 M V30 6 C 12.80927 -70.43332 0 0 M V30 7 C 32.72786 -70.43332 0 0 M V30 8 C 42.68715 -76.18332 0 0 M V30 9 C 52.64644 -70.43332 0 0 M V30 10 C 62.60573 -76.18332 0 0 M V30 11 C 72.56502 -70.43332 0 0 M V30 12 O 82.52431 -76.18332 0 0 M V30 13 C 102.44289 -76.18333 0 0 M V30 14 C 92.4836 -70.43333 0 0 M V30 15 O 72.56502 -58.93332 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 2 7 8 M V30 9 1 8 9 CFG=2 M V30 10 2 9 10 M V30 11 1 10 11 M V30 12 1 12 14 M V30 13 1 13 14 M V30 14 1 11 12 M V30 15 2 11 15 M V30 END BOND M V30 END CTAB M END DNHYZERWBNHRTC-QJPTWQEYSA-N InChI=1S/C14H23NO4/c1-3-19-13(16)12-6-4-5-10-9-15(14(17)18-2)8-7-11(10)12/h10-12H,3-9H2,1-2H3/t10-,11+,12+/m0/s1 CCOC(=O)[C@@H]1CCC[C@@]2([H])CN(CC[C@]21[H])C(=O)OC N1(CC[C@@]2([C@](C1)(CCC[C@H]2C(=O)OCC)[H])[H])C(OC)=O |(186.49,-89.18,;186.49,-100.68,;196.45,-106.43,;206.41,-100.68,;206.41,-89.18,;196.45,-83.43,;216.37,-83.43,;226.33,-89.18,;226.33,-100.68,;216.37,-106.43,;216.37,-117.93,;226.33,-123.68,;206.41,-123.68,;206.41,-135.18,;196.45,-140.93,;206.41,-77.68,;206.41,-112.18,;176.54,-83.43,;166.58,-89.18,;166.58,-100.68,;176.54,-71.93,)| AuxInfo=1/0/N:18,9,19,13,14,12,3,2,6,5,4,11,15,7,1,16,10,8,17/it:im/rA:21nNCCC.oC.oCCOCOC.oCCCCOOCCHH/rB:s1;s2;s3;s4;s1s5;s1;s7;s8;d7;s4;s11;s12;s5s13;P11;d15;s15;;s17s18;P4;P5;/rC:186,4949,-89,1833,0;186,4949,-100,6833,0;196,4542,-106,4333,0;206,4135,-100,6833,0;206,4135,-89,1833,0;196,4542,-83,4333,0;176,5356,-83,4333,0;166,5763,-89,1833,0;166,5763,-100,6833,0;176,5356,-71,9333,0;216,3728,-106,4333,0;226,3320,-100,6833,0;226,3320,-89,1833,0;216,3728,-83,4333,0;216,3728,-117,9333,0;226,3320,-123,6833,0;206,4135,-123,6833,0;196,4542,-140,9333,0;206,4135,-135,1833,0;206,4135,-112,1833,0;206,4135,-77,6833,0; C14H23NO4 CCOC(=O)* CO2Et,CO* OMe CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 21 22 0 0 1 M V30 BEGIN ATOM M V30 1 N 186.49489 -89.18332 0 0 M V30 2 C 186.49489 -100.68332 0 0 M V30 3 C 196.45416 -106.43332 0 0 M V30 4 C 206.41347 -100.68332 0 0 CFG=1 M V30 5 C 206.41347 -89.18332 0 0 CFG=1 M V30 6 C 196.45416 -83.43332 0 0 M V30 7 C 176.53558 -83.43332 0 0 M V30 8 O 166.57629 -89.18332 0 0 M V30 9 C 166.57629 -100.68332 0 0 M V30 10 O 176.53558 -71.93332 0 0 M V30 11 C 216.37276 -106.43332 0 0 CFG=2 M V30 12 C 226.33205 -100.68332 0 0 M V30 13 C 226.33205 -89.18332 0 0 M V30 14 C 216.37276 -83.43332 0 0 M V30 15 C 216.37276 -117.93332 0 0 M V30 16 O 226.33205 -123.68332 0 0 M V30 17 O 206.41345 -123.68332 0 0 M V30 18 C 196.45416 -140.93332 0 0 M V30 19 C 206.41345 -135.18332 0 0 M V30 20 H 206.41347 -112.18332 0 0 M V30 21 H 206.41347 -77.68332 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 1 2 3 M V30 3 1 3 4 M V30 4 1 4 5 M V30 5 1 5 6 M V30 6 1 6 1 M V30 7 1 1 7 M V30 8 1 8 9 M V30 9 1 7 8 M V30 10 2 7 10 M V30 11 1 4 11 M V30 12 1 11 12 M V30 13 1 12 13 M V30 14 1 13 14 M V30 15 1 14 5 M V30 16 2 15 16 M V30 17 1 15 17 M V30 18 1 17 19 M V30 19 1 18 19 M V30 20 1 11 15 CFG=1 M V30 21 1 4 20 CFG=1 M V30 22 1 5 21 CFG=1 M V30 END BOND M V30 END CTAB M END JTRYFJWNUYPWLN-VXGBXAGGSA-N InChI=1S/C14H19NO4/c1-3-19-13(16)12-6-4-5-10-9-15(14(17)18-2)8-7-11(10)12/h7-9,11-12H,3-6H2,1-2H3/t11-,12-/m1/s1 CCOC(=O)[C@@H]1CCCC2=CN(C=C[C@]21[H])C(=O)OC N1(C=C[C@@]2(C(=C1)CCC[C@H]2C(=O)OCC)[H])C(OC)=O |(46.99,-89.18,;46.99,-100.68,;56.95,-106.43,;66.91,-100.68,;66.91,-89.18,;56.95,-83.43,;76.87,-83.43,;86.83,-89.18,;86.83,-100.68,;76.87,-106.43,;76.87,-117.93,;86.83,-123.68,;66.91,-123.68,;66.91,-135.18,;56.95,-140.93,;66.91,-112.18,;37.04,-83.43,;27.08,-89.18,;27.08,-100.68,;37.04,-71.93,)| AuxInfo=1/0/N:18,9,19,13,14,12,3,2,6,5,4,11,15,7,1,16,10,8,17/it:im/rA:20nNCCC.oCCCOCOC.oCCCCOOCCH/rB:s1;d2;s3;s4;s1d5;s1;s7;s8;d7;s4;s11;s12;s5s13;P11;d15;s15;;s17s18;P4;/rC:46,9949,-89,1833,0;46,9949,-100,6833,0;56,9542,-106,4333,0;66,9135,-100,6833,0;66,9135,-89,1833,0;56,9542,-83,4333,0;37,0356,-83,4333,0;27,0763,-89,1833,0;27,0763,-100,6833,0;37,0356,-71,9333,0;76,8728,-106,4333,0;86,8320,-100,6833,0;86,8320,-89,1833,0;76,8728,-83,4333,0;76,8728,-117,9333,0;86,8320,-123,6833,0;66,9135,-123,6833,0;56,9542,-140,9333,0;66,9135,-135,1833,0;66,9135,-112,1833,0; C14H19NO4 CCOC(=O)* CO2Et,CO* OMe CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 20 21 0 0 1 M V30 BEGIN ATOM M V30 1 N 46.99489 -89.18332 0 0 M V30 2 C 46.99489 -100.68332 0 0 M V30 3 C 56.95416 -106.43332 0 0 M V30 4 C 66.91347 -100.68332 0 0 CFG=1 M V30 5 C 66.91347 -89.18332 0 0 M V30 6 C 56.95416 -83.43332 0 0 M V30 7 C 37.03558 -83.43332 0 0 M V30 8 O 27.07629 -89.18332 0 0 M V30 9 C 27.07629 -100.68332 0 0 M V30 10 O 37.03558 -71.93332 0 0 M V30 11 C 76.87276 -106.43332 0 0 CFG=2 M V30 12 C 86.83205 -100.68332 0 0 M V30 13 C 86.83205 -89.18332 0 0 M V30 14 C 76.87276 -83.43332 0 0 M V30 15 C 76.87276 -117.93332 0 0 M V30 16 O 86.83205 -123.68332 0 0 M V30 17 O 66.91345 -123.68332 0 0 M V30 18 C 56.95416 -140.93332 0 0 M V30 19 C 66.91345 -135.18332 0 0 M V30 20 H 66.91347 -112.18332 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 2 2 3 M V30 3 1 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 1 7 M V30 8 1 8 9 M V30 9 1 7 8 M V30 10 2 7 10 M V30 11 1 4 11 M V30 12 1 11 12 M V30 13 1 12 13 M V30 14 1 13 14 M V30 15 1 14 5 M V30 16 2 15 16 M V30 17 1 15 17 M V30 18 1 17 19 M V30 19 1 18 19 M V30 20 1 11 15 CFG=1 M V30 21 1 4 20 CFG=1 M V30 END BOND M V30 END CTAB M END LRZJEAOVTAKKLT-PTNGSMBKSA-N InChI=1S/C15H25NO2Si/c1-5-17-15(18-19(2,3)4)11-7-6-9-14-10-8-12-16-13-14/h8,10-13H,5-7,9H2,1-4H3/b15-11- CCO/C(=C/CCCC1=CC=CN=C1)/O[Si](C)(C)C N1=CC=CC(=C1)CCCC=C(OCC)O[Si](C)(C)C |(87.99,-32.18,;87.99,-43.68,;97.95,-49.43,;107.91,-43.68,;107.91,-32.18,;97.95,-26.43,;117.87,-26.43,;127.83,-32.18,;137.79,-26.43,;147.75,-32.18,;157.71,-26.43,;167.67,-32.18,;177.63,-26.43,;187.59,-32.18,;157.71,-14.93,;147.75,-9.18,;137.79,-3.43,;137.79,-14.93,;147.75,2.32,)| AuxInfo=1/0/N:13,17,18,19,14,8,9,3,7,4,10,2,6,5,11,1,12,15,16/E:(2,3,4)/rA:19nNCCCCCCCCCCOCCOSiCCC/rB:d1;s2;d3;s4;s1d5;s5;s7;s8;s9;d+10;s11;;s12s13;s11;s15;s16;s16;s16;/rC:87,9949,-32,1833,0;87,9949,-43,6833,0;97,9542,-49,4333,0;107,9135,-43,6833,0;107,9135,-32,1833,0;97,9542,-26,4333,0;117,8728,-26,4333,0;127,8320,-32,1833,0;137,7913,-26,4333,0;147,7506,-32,1833,0;157,7099,-26,4333,0;167,6692,-32,1833,0;187,5878,-32,1833,0;177,6285,-26,4333,0;157,7099,-14,9333,0;147,7506,-9,1833,0;137,7913,-3,4333,0;137,7913,-14,9333,0;147,7506,2,3167,0; C15H25NO2Si CCO* OEt,C[Si](C)(C)O* OSiMe3 CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 19 19 0 0 0 M V30 BEGIN ATOM M V30 1 N 87.99489 -32.18332 0 0 M V30 2 C 87.99489 -43.68332 0 0 M V30 3 C 97.95416 -49.43332 0 0 M V30 4 C 107.91347 -43.68332 0 0 M V30 5 C 107.91347 -32.18332 0 0 M V30 6 C 97.95416 -26.43332 0 0 M V30 7 C 117.87276 -26.43332 0 0 M V30 8 C 127.83205 -32.18332 0 0 M V30 9 C 137.79134 -26.43332 0 0 M V30 10 C 147.75063 -32.18332 0 0 M V30 11 C 157.70992 -26.43332 0 0 M V30 12 O 167.6692 -32.18332 0 0 M V30 13 C 187.58778 -32.18333 0 0 M V30 14 C 177.62849 -26.43333 0 0 M V30 15 O 157.70992 -14.93332 0 0 M V30 16 Si 147.75061 -9.18332 0 0 M V30 17 C 137.79132 -3.43332 0 0 M V30 18 C 137.79132 -14.93332 0 0 M V30 19 C 147.75061 2.31668 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 8 M V30 9 1 8 9 M V30 10 1 9 10 M V30 11 2 10 11 M V30 12 1 12 14 M V30 13 1 13 14 M V30 14 1 11 12 M V30 15 1 15 16 M V30 16 1 16 17 M V30 17 1 16 18 M V30 18 1 16 19 M V30 19 1 11 15 M V30 END BOND M V30 END CTAB M END MVQVNTPHUGQQHK-UHFFFAOYSA-N InChI=1S/C6H7NO/c8-5-6-2-1-3-7-4-6/h1-4,8H,5H2 C1=CN=CC(=C1)CO N1=CC=CC(=C1)CO |(2.85,-28.57,;2.85,-40.07,;12.81,-45.82,;22.77,-40.07,;22.77,-28.57,;12.81,-22.82,;32.73,-22.82,;42.69,-28.57,)| AuxInfo=1/0/N:3,4,2,6,7,5,1,8/rA:8nNCCCCCCO/rB:d1;s2;d3;s4;s1d5;s5;s7;/rC:2,8500,-28,5667,0;2,8500,-40,0667,0;12,8093,-45,8167,0;22,7686,-40,0667,0;22,7686,-28,5667,0;12,8093,-22,8167,0;32,7279,-22,8167,0;42,6871,-28,5667,0; C6H7NO CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 8 8 0 0 0 M V30 BEGIN ATOM M V30 1 N 2.84999 -28.56665 0 0 M V30 2 C 2.84999 -40.06665 0 0 M V30 3 C 12.80927 -45.81665 0 0 M V30 4 C 22.76857 -40.06665 0 0 M V30 5 C 22.76857 -28.56665 0 0 M V30 6 C 12.80927 -22.81665 0 0 M V30 7 C 32.72786 -22.81665 0 0 M V30 8 O 42.68715 -28.56665 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 8 M V30 END BOND M V30 END CTAB M END HSOIXTVLJSEGAG-UHFFFAOYSA-N InChI=1S/C10H13NO3/c1-8(10(12)13-2)14-7-9-4-3-5-11-6-9/h3-6,8H,7H2,1-2H3 CC(C(=O)OC)OCC1=CC=CN=C1 N1=CC=CC(=C1)COC(C(=O)OC)C |(2.87,-156.63,;2.87,-167.78,;12.53,-173.35,;22.18,-167.78,;22.18,-156.63,;12.53,-151.06,;31.83,-151.06,;41.48,-156.63,;51.13,-151.06,;60.79,-156.63,;70.44,-151.06,;60.79,-167.78,;70.44,-173.35,;51.13,-139.91,)| AuxInfo=1/0/N:14,13,3,4,2,6,7,9,5,10,1,11,12,8/rA:14nNCCCCCCOCCOOCC/rB:d1;s2;d3;s4;s1d5;s5;s7;s8;s9;d10;s10;s12;s9;/rC:2,8750,-156,6325,0;2,8750,-167,7774,0;12,5268,-173,3499,0;22,1786,-167,7774,0;22,1786,-156,6325,0;12,5268,-151,0600,0;31,8305,-151,0600,0;41,4823,-156,6325,0;51,1341,-151,0600,0;60,7859,-156,6325,0;70,4378,-151,0600,0;60,7859,-167,7774,0;70,4378,-173,3499,0;51,1341,-139,9150,0; C10H13NO3 COC(=O)* CO2Me CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 14 14 0 0 0 M V30 BEGIN ATOM M V30 1 N 2.87498 -156.63246 0 0 M V30 2 C 2.87498 -167.77744 0 0 M V30 3 C 12.52679 -173.34991 0 0 M V30 4 C 22.17863 -167.77744 0 0 M V30 5 C 22.17863 -156.63246 0 0 M V30 6 C 12.52679 -151.05998 0 0 M V30 7 C 31.83046 -151.05998 0 0 M V30 8 O 41.48228 -156.63246 0 0 M V30 9 C 51.13412 -151.05998 0 0 M V30 10 C 60.78595 -156.63246 0 0 M V30 11 O 70.43777 -151.05998 0 0 M V30 12 O 60.78593 -167.77742 0 0 M V30 13 C 70.43777 -173.34991 0 0 M V30 14 C 51.13412 -139.91499 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 8 M V30 9 1 8 9 M V30 10 2 10 11 M V30 11 1 10 12 M V30 12 1 12 13 M V30 13 1 9 10 M V30 14 1 9 14 M V30 END BOND M V30 END CTAB M END KDDZZXLKDFOTOE-LNLATYFQSA-N InChI=1S/C12H19NO5/c1-12(10(14)16-2)9-4-5-13(11(15)17-3)6-8(9)7-18-12/h8-9H,4-7H2,1-3H3/t8-,9-,12+/m1/s1 C[C@]1([C@]2([H])CCN(C[C@]2([H])CO1)C(=O)OC)C(=O)OC N1(CC[C@@]2([C@](C1)(CO[C@@]2(C(=O)OC)C)[H])[H])C(OC)=O |(91.55,-211.39,;91.55,-222.53,;101.2,-228.11,;110.85,-222.53,;110.85,-211.39,;101.2,-205.82,;121.45,-207.94,;128,-216.96,;121.45,-225.98,;121.45,-237.12,;131.11,-242.69,;111.8,-242.69,;111.8,-253.84,;132.22,-228.86,;110.85,-200.24,;110.85,-233.68,;81.9,-205.82,;72.25,-211.39,;72.25,-222.53,;81.9,-194.67,)| AuxInfo=1/0/N:20,18,9,3,2,6,14,5,4,15,7,12,1,16,10,17,8,13/it:im/rA:20nNCCC.eC.oCCOCOHC.oOCCOOCHC/rB:s1;s2;s3;s4;s1s5;s1;s7;s8;d7;P4;s4;s12;s5s13;N12;d15;s15;s17;P5;P12;/rC:91,5502,-211,3882,0;91,5502,-222,5332,0;101,2020,-228,1057,0;110,8539,-222,5332,0;110,8539,-211,3882,0;101,2020,-205,8157,0;81,8984,-205,8157,0;72,2465,-211,3882,0;72,2465,-222,5332,0;81,8984,-194,6707,0;110,8539,-233,6781,0;121,4533,-225,9771,0;128,0042,-216,9607,0;121,4533,-207,9442,0;121,4533,-237,1221,0;131,1052,-242,6946,0;111,8015,-242,6946,0;111,8015,-253,8396,0;110,8539,-200,2432,0;132,2186,-228,8617,0; C12H19NO5 COC(=O)* CO2Me,CO* OMe CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 20 21 0 0 1 M V30 BEGIN ATOM M V30 1 N 91.5502 -211.3882 0 0 M V30 2 C 91.5502 -222.53316 0 0 M V30 3 C 101.20201 -228.10565 0 0 M V30 4 C 110.85385 -222.53316 0 0 CFG=1 M V30 5 C 110.85385 -211.3882 0 0 CFG=1 M V30 6 C 101.20201 -205.8157 0 0 M V30 7 C 81.89836 -205.8157 0 0 M V30 8 O 72.24652 -211.3882 0 0 M V30 9 C 72.24652 -222.53316 0 0 M V30 10 O 81.89836 -194.67075 0 0 M V30 11 C 121.45334 -225.97714 0 0 CFG=1 M V30 12 O 128.0042 -216.96068 0 0 M V30 13 C 121.45334 -207.9442 0 0 M V30 14 C 121.45334 -237.1221 0 0 M V30 15 O 131.10518 -242.69456 0 0 M V30 16 O 111.8015 -242.6946 0 0 M V30 17 C 111.8015 -253.83957 0 0 M V30 18 C 132.21857 -228.86166 0 0 M V30 19 H 110.85385 -233.67813 0 0 M V30 20 H 110.85385 -200.24323 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 1 2 3 M V30 3 1 3 4 M V30 4 1 4 5 M V30 5 1 5 6 M V30 6 1 6 1 M V30 7 1 1 7 M V30 8 1 8 9 M V30 9 1 7 8 M V30 10 2 7 10 M V30 11 1 4 19 CFG=1 M V30 12 1 4 11 M V30 13 1 11 12 M V30 14 1 12 13 M V30 15 1 13 5 M V30 16 2 14 15 M V30 17 1 14 16 M V30 18 1 16 17 M V30 19 1 11 14 CFG=3 M V30 20 1 5 20 CFG=1 M V30 21 1 11 18 CFG=1 M V30 END BOND M V30 END CTAB M END KQKSTKOUKKOXET-MNOVXSKESA-N InChI=1S/C14H19NO5/c1-14(2,3)20-12(16)11-10-5-6-15(13(17)18-4)7-9(10)8-19-11/h5-7,10-11H,8H2,1-4H3/t10-,11+/m1/s1 CC(C)(C)OC(=O)[C@@H]1[C@]2([H])C=CN(C=C2CO1)C(=O)OC N1(C=C[C@@]2(C(=C1)CO[C@@H]2C(=O)OC(C)(C)C)[H])C(OC)=O |(173.08,-21.44,;173.08,-32.58,;182.74,-38.16,;192.39,-32.58,;192.39,-21.44,;182.74,-15.87,;202.99,-18,;209.54,-27.01,;202.99,-36.03,;206.43,-46.63,;217.33,-48.94,;198.97,-54.91,;202.42,-65.51,;194.96,-73.79,;205.86,-76.11,;213.32,-67.83,;192.39,-43.73,;163.43,-15.87,;153.78,-21.44,;153.78,-32.58,;163.43,-4.72,)| AuxInfo=1/0/N:19,20,21,9,3,2,6,14,5,4,12,15,7,18,1,16,10,8,13,17/E:(1,2,3)/it:im/rA:21nNCCC.eCCCOCOHC.eOCCOOCCCC/rB:s1;d2;s3;s4;s1d5;s1;s7;s8;d7;P4;s4;s12;s5s13;N12;d15;s15;s17;s18;s18;s18;/rC:173,0835,-21,4391,0;173,0835,-32,5841,0;182,7353,-38,1566,0;192,3871,-32,5841,0;192,3871,-21,4391,0;182,7353,-15,8666,0;163,4316,-15,8666,0;153,7798,-21,4391,0;153,7798,-32,5841,0;163,4316,-4,7216,0;192,3871,-43,7290,0;202,9866,-36,0280,0;209,5375,-27,0116,0;202,9866,-17,9951,0;206,4306,-46,6275,0;217,3320,-48,9447,0;198,9731,-54,9099,0;202,4171,-65,5094,0;194,9597,-73,7917,0;205,8611,-76,1089,0;213,3186,-67,8266,0; C14H19NO5 CC(C)(C)OC(=O)* CO2t-Bu,CO* OMe CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 21 22 0 0 1 M V30 BEGIN ATOM M V30 1 N 173.08347 -21.43912 0 0 M V30 2 C 173.08347 -32.58408 0 0 M V30 3 C 182.73528 -38.15657 0 0 M V30 4 C 192.3871 -32.58408 0 0 CFG=1 M V30 5 C 192.3871 -21.43912 0 0 M V30 6 C 182.73528 -15.86662 0 0 M V30 7 C 163.43163 -15.86662 0 0 M V30 8 O 153.7798 -21.43912 0 0 M V30 9 C 153.7798 -32.58408 0 0 M V30 10 O 163.43163 -4.72165 0 0 M V30 11 C 202.9866 -36.02805 0 0 CFG=1 M V30 12 O 209.53746 -27.0116 0 0 M V30 13 C 202.9866 -17.99512 0 0 M V30 14 C 206.43059 -46.62755 0 0 M V30 15 O 217.33202 -48.94472 0 0 M V30 16 O 198.97314 -54.90988 0 0 M V30 17 C 202.41711 -65.50937 0 0 M V30 18 C 194.95969 -73.7917 0 0 M V30 19 C 205.86111 -76.10887 0 0 M V30 20 C 213.31856 -67.82655 0 0 M V30 21 H 192.3871 -43.72905 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 2 2 3 M V30 3 1 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 1 7 M V30 8 1 8 9 M V30 9 1 7 8 M V30 10 2 7 10 M V30 11 1 4 21 CFG=1 M V30 12 1 4 11 M V30 13 1 11 12 M V30 14 1 12 13 M V30 15 1 13 5 M V30 16 2 14 15 M V30 17 1 14 16 M V30 18 1 16 17 M V30 19 1 17 18 M V30 20 1 17 19 M V30 21 1 17 20 M V30 22 1 11 14 CFG=3 M V30 END BOND M V30 END CTAB M END VZASOSIXMJNLAI-UHFFFAOYSA-N InChI=1S/C12H17NO3/c1-12(2,3)16-11(14)9-15-8-10-5-4-6-13-7-10/h4-7H,8-9H2,1-3H3 CC(C)(C)OC(=O)COCC1=CC=CN=C1 N1=CC=CC(=C1)COCC(=O)OC(C)(C)C |(2.87,-24.83,;2.87,-35.98,;12.53,-41.55,;22.18,-35.98,;22.18,-24.83,;12.53,-19.26,;31.83,-19.26,;41.48,-24.83,;51.13,-19.26,;60.79,-24.83,;70.44,-19.26,;60.79,-35.98,;70.44,-41.55,;70.44,-52.69,;80.09,-47.12,;80.09,-35.98,)| AuxInfo=1/0/N:14,15,16,3,4,2,6,7,9,5,10,13,1,11,8,12/E:(1,2,3)/rA:16nNCCCCCCOCCOOCCCC/rB:d1;s2;d3;s4;s1d5;s5;s7;s8;s9;d10;s10;s12;s13;s13;s13;/rC:2,8750,-24,8311,0;2,8750,-35,9760,0;12,5268,-41,5485,0;22,1786,-35,9760,0;22,1786,-24,8311,0;12,5268,-19,2586,0;31,8305,-19,2586,0;41,4823,-24,8311,0;51,1341,-19,2586,0;60,7859,-24,8311,0;70,4378,-19,2586,0;60,7859,-35,9760,0;70,4378,-41,5485,0;70,4378,-52,6935,0;80,0896,-47,1210,0;80,0896,-35,9760,0; C12H17NO3 CC(C)(C)OC(=O)* CO2t-Bu CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 16 16 0 0 0 M V30 BEGIN ATOM M V30 1 N 2.87498 -24.83105 0 0 M V30 2 C 2.87498 -35.97601 0 0 M V30 3 C 12.52679 -41.54851 0 0 M V30 4 C 22.17863 -35.97601 0 0 M V30 5 C 22.17863 -24.83105 0 0 M V30 6 C 12.52679 -19.25858 0 0 M V30 7 C 31.83046 -19.25858 0 0 M V30 8 O 41.48228 -24.83105 0 0 M V30 9 C 51.13412 -19.25858 0 0 M V30 10 C 60.78595 -24.83105 0 0 M V30 11 O 70.43777 -19.25858 0 0 M V30 12 O 60.78593 -35.976 0 0 M V30 13 C 70.43777 -41.54851 0 0 M V30 14 C 70.43776 -52.6935 0 0 M V30 15 C 80.08958 -47.12099 0 0 M V30 16 C 80.08958 -35.97601 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 8 M V30 9 1 8 9 M V30 10 2 10 11 M V30 11 1 10 12 M V30 12 1 12 13 M V30 13 1 13 14 M V30 14 1 13 15 M V30 15 1 13 16 M V30 16 1 9 10 M V30 END BOND M V30 END CTAB M END XTABUFHTBAOXSX-MXWKQRLJSA-N InChI=1S/C14H23NO5/c1-14(2,3)20-12(16)11-10-5-6-15(13(17)18-4)7-9(10)8-19-11/h9-11H,5-8H2,1-4H3/t9-,10-,11+/m1/s1 CC(C)(C)OC(=O)[C@@H]1[C@]2([H])CCN(C[C@]2([H])CO1)C(=O)OC N1(CC[C@@]2([C@](C1)(CO[C@@H]2C(=O)OC(C)(C)C)[H])[H])C(OC)=O |(91.55,-79.59,;91.55,-90.73,;101.2,-96.3,;110.85,-90.73,;110.85,-79.59,;101.2,-74.01,;121.45,-76.14,;128,-85.16,;121.45,-94.18,;124.9,-104.78,;135.8,-107.09,;117.44,-113.06,;120.88,-123.66,;113.43,-131.94,;124.33,-134.26,;131.79,-125.97,;110.85,-68.44,;110.85,-101.88,;81.9,-74.01,;72.25,-79.59,;72.25,-90.73,;81.9,-62.87,)| AuxInfo=1/0/N:19,20,21,9,3,2,6,14,5,4,12,15,7,18,1,16,10,8,13,17/E:(1,2,3)/it:im/rA:22nNCCC.eC.oCCOCOHC.eOCCOOCCCCH/rB:s1;s2;s3;s4;s1s5;s1;s7;s8;d7;P4;s4;s12;s5s13;N12;d15;s15;s17;s18;s18;s18;P5;/rC:91,5502,-79,5868,0;91,5502,-90,7318,0;101,2020,-96,3042,0;110,8539,-90,7318,0;110,8539,-79,5868,0;101,2020,-74,0143,0;81,8984,-74,0143,0;72,2465,-79,5868,0;72,2465,-90,7318,0;81,8984,-62,8693,0;110,8539,-101,8767,0;121,4533,-94,1757,0;128,0042,-85,1593,0;121,4533,-76,1428,0;124,8973,-104,7752,0;135,7988,-107,0924,0;117,4399,-113,0576,0;120,8839,-123,6571,0;113,4264,-131,9394,0;124,3279,-134,2566,0;131,7853,-125,9742,0;110,8539,-68,4418,0; C14H23NO5 CC(C)(C)OC(=O)* CO2t-Bu,CO* OMe CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 22 23 0 0 1 M V30 BEGIN ATOM M V30 1 N 91.5502 -79.58678 0 0 M V30 2 C 91.5502 -90.73175 0 0 M V30 3 C 101.20201 -96.30424 0 0 M V30 4 C 110.85385 -90.73175 0 0 CFG=1 M V30 5 C 110.85385 -79.58678 0 0 CFG=1 M V30 6 C 101.20201 -74.0143 0 0 M V30 7 C 81.89836 -74.0143 0 0 M V30 8 O 72.24652 -79.58678 0 0 M V30 9 C 72.24652 -90.73175 0 0 M V30 10 O 81.89836 -62.86932 0 0 M V30 11 C 121.45334 -94.17572 0 0 CFG=1 M V30 12 O 128.0042 -85.15927 0 0 M V30 13 C 121.45334 -76.14279 0 0 M V30 14 C 124.89731 -104.77524 0 0 M V30 15 O 135.79875 -107.09241 0 0 M V30 16 O 117.43988 -113.05756 0 0 M V30 17 C 120.88385 -123.65706 0 0 M V30 18 C 113.42642 -131.93938 0 0 M V30 19 C 124.32785 -134.25656 0 0 M V30 20 C 131.78529 -125.97423 0 0 M V30 21 H 110.85385 -101.87674 0 0 M V30 22 H 110.85385 -68.44182 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 1 2 3 M V30 3 1 3 4 M V30 4 1 4 5 M V30 5 1 5 6 M V30 6 1 6 1 M V30 7 1 1 7 M V30 8 1 8 9 M V30 9 1 7 8 M V30 10 2 7 10 M V30 11 1 4 21 CFG=1 M V30 12 1 4 11 M V30 13 1 11 12 M V30 14 1 12 13 M V30 15 1 13 5 M V30 16 2 14 15 M V30 17 1 14 16 M V30 18 1 16 17 M V30 19 1 17 18 M V30 20 1 17 19 M V30 21 1 17 20 M V30 22 1 11 14 CFG=3 M V30 23 1 5 22 CFG=1 M V30 END BOND M V30 END CTAB M END YWTAHXKBWFDFIK-SKDRFNHKSA-N InChI=1S/C12H15NO5/c1-12(10(14)16-2)9-4-5-13(11(15)17-3)6-8(9)7-18-12/h4-6,9H,7H2,1-3H3/t9-,12+/m1/s1 C[C@]1([C@]2([H])C=CN(C=C2CO1)C(=O)OC)C(=O)OC N1(C=C[C@@]2(C(=C1)CO[C@@]2(C(=O)OC)C)[H])C(OC)=O |(176.83,-153.24,;176.83,-164.39,;186.49,-169.96,;196.14,-164.39,;196.14,-153.24,;186.49,-147.67,;206.74,-149.8,;213.29,-158.81,;206.74,-167.83,;206.74,-178.97,;216.39,-184.55,;197.08,-184.55,;197.08,-195.69,;217.5,-170.71,;196.14,-175.53,;167.18,-147.67,;157.53,-153.24,;157.53,-164.39,;167.18,-136.52,)| AuxInfo=1/0/N:19,18,9,3,2,6,14,5,4,15,7,12,1,16,10,17,8,13/it:im/rA:19nNCCC.eCCCOCOHC.oOCCOOCC/rB:s1;d2;s3;s4;s1d5;s1;s7;s8;d7;P4;s4;s12;s5s13;N12;d15;s15;s17;P12;/rC:176,8335,-153,2405,0;176,8335,-164,3855,0;186,4853,-169,9580,0;196,1371,-164,3855,0;196,1371,-153,2405,0;186,4853,-147,6680,0;167,1816,-147,6680,0;157,5298,-153,2405,0;157,5298,-164,3855,0;167,1816,-136,5231,0;196,1371,-175,5305,0;206,7366,-167,8295,0;213,2875,-158,8130,0;206,7366,-149,7965,0;206,7366,-178,9744,0;216,3884,-184,5469,0;197,0848,-184,5469,0;197,0848,-195,6919,0;217,5018,-170,7140,0; C12H15NO5 COC(=O)* CO2Me,CO* OMe CDK 04222607212D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 19 20 0 0 1 M V30 BEGIN ATOM M V30 1 N 176.83347 -153.24051 0 0 M V30 2 C 176.83347 -164.3855 0 0 M V30 3 C 186.48528 -169.95798 0 0 M V30 4 C 196.1371 -164.3855 0 0 CFG=1 M V30 5 C 196.1371 -153.24051 0 0 M V30 6 C 186.48528 -147.66803 0 0 M V30 7 C 167.18163 -147.66803 0 0 M V30 8 O 157.5298 -153.24051 0 0 M V30 9 C 157.5298 -164.3855 0 0 M V30 10 O 167.18163 -136.52306 0 0 M V30 11 C 206.7366 -167.82945 0 0 CFG=1 M V30 12 O 213.28746 -158.81299 0 0 M V30 13 C 206.7366 -149.79654 0 0 M V30 14 C 206.7366 -178.97443 0 0 M V30 15 O 216.38844 -184.54692 0 0 M V30 16 O 197.08476 -184.54692 0 0 M V30 17 C 197.08476 -195.69188 0 0 M V30 18 C 217.50183 -170.71397 0 0 M V30 19 H 196.1371 -175.53046 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 2 2 3 M V30 3 1 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 1 7 M V30 8 1 8 9 M V30 9 1 7 8 M V30 10 2 7 10 M V30 11 1 4 19 CFG=1 M V30 12 1 4 11 M V30 13 1 11 12 M V30 14 1 12 13 M V30 15 1 13 5 M V30 16 2 14 15 M V30 17 1 14 16 M V30 18 1 16 17 M V30 19 1 11 14 CFG=3 M V30 20 1 11 18 CFG=1 M V30 END BOND M V30 END CTAB M END Synthesis and characterisation data of starting materials We are grateful to the EPSRC, GlaxoSmithKline (HB) and AstraZeneca (SH) for studentships, and to Drs Emma Blaney and Rukhsana Mohammed for valuable discussions. 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