Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: +91-40-27160512 <chunk>Synthesis of (3</chunk> <chunk italic="yes">R</chunk> <chunk>,5</chunk> <chunk italic="yes">R</chunk> <chunk>)-harzialactone A and its (3</chunk> <chunk italic="yes">R</chunk> <chunk>,5</chunk> <chunk italic="yes">S</chunk> <chunk>)-isomer</chunk> dithiane harzialactone A hydroxyl directed reduction stereoisomer The total synthesis of (3 R ,5 R )-harzialactone A ( 1 ) and its (3 R ,5 S )-isomer ( 2 ) is described. Epoxide opening with thioacetal and diastereoselective reductions are used as key reactions.
<chunk>Introduction</chunk> Marine microorganisms such as bacteria, fungi, and microalgae have proved to be a rich source of structurally novel and biologically active secondary metabolites . (+)-Harzialactone A ( 1 ), a marine metabolite isolated from the culture broth of a strain of Trichoderma harzianum OUPS-N115 by Numata and co-workers, exhibited antitumor and cytotoxic activities against cultured P388 cells . The absolute configuration of (+)- 1 was established based on 1 H NMR studies and by its synthesis  . Harzialactone A ( 1 ) ( ) is a synthetic target of considerable interest due to its potent biological activity and unique structure. A few methods for its synthesis have been documented in the literature as well as a synthesis of nonnatural (−)-harzialactone A . However, the anti-tumor activity of Harzialactone A coupled with its unique structural architecture prompted us to attempt its synthesis. The retrosynthesis is depicted in . Harzialactone 1 could be made from 3 by successive protecting group transformations. 3 can be made by hydroxyl directed reduction of 4 which in turn could be prepared by epoxide 6 opening with dithiane 5 .
<chunk>Results and Discussion</chunk> The synthesis of natural (3 R ,5 R )- 1 was initiated from the known epoxide 6 , which is commercially available. Treatment of 2-phenylacetaldehyde 7 with 1,3-propanedithiol in the presence of BF 3 ·Et 2 O in CH 2 Cl 2 afforded thioacetal 5 in 90% yield ( ). The epoxide 6 was coupled with the acyl anion equivalent 5 (1.0 equiv), prepared by metallation at –78 °C with 1.0 equiv of n -butyllithium in the presence of BF 3 ·Et 2 O to obtain 8 in 64% yield. Removal of the dithioketal using HgCl 2 /CaCO 3 in CH 3 CN/H 2 O (4:1) provided the corresponding hydroxyketone 4 in 82% yield. Treatment of 5 with NaBH 4 and MeOBEt 2 stereoselectively formed the syn diol 9 in good yield (80%). The diol 9 was subsequently transformed into the isopropylidene derivative 3 by treatment with 2,2-dimethoxypropane and a catalytic amount of PPTS in CH 2 Cl 2 . In the 13 C NMR spectrum of 3 , the acetonide methyl groups resonated at 19.6 and 29.9 ppm indicating a 1,3- syn -relationship that was further substantiated by the appearance of the quaternary carbon in the downfield region (98.7 ppm). Deprotection of the benzyl group using Li/liq. NH 3 gave alcohol 10 . Oxidation of alcohol 10 under Swern conditions and further oxidation of the resulting aldehyde using NaH 2 PO 4 , NaClO 2 in DMSO/H 2 O furnished the target hydroxylactone (3 R ,5 R )- 1 as reported earlier. The IR absorption at 1774 cm −1 indicates the presence of δ-lactone system. The synthesis of (3 R ,5 S )- 2 was also accomplished in an identical manner from 4 ( ). The substrate hydroxyl directed asymmetric reduction with Me 4 NBH(OAc) 3 was performed at 0 °C to afford the anti diol 11 as the major product, which was converted into stereoisomer (3 R ,5 S )- 2 via acetonide 12 , deprotection of benzyl group to give 13 , and further functional group transformations by use of the same reagents and conditions as those described for the conversion of 10 into 1 . The IR absorption at 1775 cm −1 confirms the presence of δ-lactone in (3 R ,5 S )- 2 . The anti relationship of two hydroxyl groups was studied in compound 12 . In the 13 C NMR of 12 , the acetonide methyl groups resonated at 24.9 and 34.2 ppm indicating a 1,3- anti -relationship that was further substantiated by the appearance of the quaternary carbon in the downfield region (100.5 ppm) . In conclusion, a stereoselective synthesis of natural (+)-(3 R ,5 R )-harzialactone A and its nonnatural stereoisomer (3 R ,5 S ) has been accomplished.
Natural harzialactone A ( 1 ), and its (3 R ,5 S )-isomer ( 2 ).
Retrosynthesis of harzialactone A ( 1 ). Synthesis of natural harzialactone A ( 1 ). Synthesis of (3 R ,5 S )-harzialactone A ( 2 ). QDWGWZDQSRYLTG-NXEZZACHSA-N InChI=1S/C11H12O3/c12-10-7-9(14-11(10)13)6-8-4-2-1-3-5-8/h1-5,9-10,12H,6-7H2/t9-,10-/m1/s1 C1=CC=C(C=C1)C[C@@H]2C[C@H](C(=O)O2)O C1[C@H](C(O[C@@H]1CC2=CC=CC=C2)=O)O |(52.2,-85.81,;65.88,-85.81,;70.15,-72.86,;59.04,-64.73,;47.92,-72.86,;35.99,-65.95,;24.09,-72.69,;12.32,-65.78,;0.44,-72.51,;0.34,-86.16,;12.1,-93.07,;23.98,-86.34,;83.16,-68.64,;73.92,-96.92,)| AuxInfo=1/0/N:10,9,11,8,12,6,1,7,5,2,3,13,14,4/E:(2,3)(4,5)/it:im/rA:14nCC.eCOC.eCCCCCCCOO/rB:s1;s2;s3;s1s4;P5;s6;d7;s8;d9;s10;s7d11;N2;d3;/rC:52,1954,-85,8114,0;65,8755,-85,8114,0;70,1513,-72,8628,0;59,0355,-64,7281,0;47,9219,-72,8628,0;35,9860,-65,9462,0;24,0861,-72,6926,0;12,3188,-65,7750,0;,4443,-72,5070,0;,3372,-86,1566,0;12,1045,-93,0742,0;23,9789,-86,3422,0;73,9173,-96,9247,0;83,1586,-68,6368,0; C11H12O3 C1=CC=C(C=C1)* Ph CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 14 15 0 0 1 M V30 BEGIN ATOM M V30 1 C 52.19536 -85.81139 0 0 M V30 2 C 65.87555 -85.81139 0 0 CFG=1 M V30 3 C 70.15128 -72.86279 0 0 M V30 4 O 59.03546 -64.72813 0 0 M V30 5 C 47.92189 -72.86279 0 0 CFG=1 M V30 6 C 35.98601 -65.94623 0 0 M V30 7 C 24.08611 -72.69263 0 0 M V30 8 C 12.3188 -65.77502 0 0 M V30 9 C 0.44434 -72.507 0 0 M V30 10 C 0.33716 -86.15657 0 0 M V30 11 C 12.10446 -93.07417 0 0 M V30 12 C 23.97893 -86.34219 0 0 M V30 13 O 73.91727 -96.92468 0 0 M V30 14 O 83.15863 -68.6368 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 1 2 3 M V30 3 1 3 4 M V30 4 1 4 5 M V30 5 1 5 1 M V30 6 1 5 6 CFG=1 M V30 7 2 7 8 M V30 8 1 8 9 M V30 9 2 9 10 M V30 10 1 10 11 M V30 11 2 11 12 M V30 12 1 7 12 M V30 13 1 6 7 M V30 14 1 2 13 CFG=3 M V30 15 2 3 14 M V30 END BOND M V30 END CTAB M END QDWGWZDQSRYLTG-VHSXEESVSA-N InChI=1S/C11H12O3/c12-10-7-9(14-11(10)13)6-8-4-2-1-3-5-8/h1-5,9-10,12H,6-7H2/t9-,10+/m0/s1 C1=CC=C(C=C1)C[C@H]2C[C@H](C(=O)O2)O C1[C@H](C(O[C@H]1CC2=CC=CC=C2)=O)O |(175.79,-85.81,;189.47,-85.81,;193.74,-72.86,;182.63,-64.73,;171.51,-72.86,;159.48,-65.85,;147.68,-72.69,;135.8,-65.79,;124,-72.47,;123.82,-86.18,;135.62,-93.07,;147.6,-86.36,;206.75,-68.64,;197.51,-96.92,)| AuxInfo=1/0/N:10,11,12,13,9,14,1,8,5,2,3,6,7,4/E:(2,3)(4,5)/it:im/rA:14nCC.eCOC.oOOCCCCCCC/rB:s1;s2;s3;s1s4;N2;d3;;d8;;s10;s9d10;s8d11;N5s8;/rC:175,7856,-85,8114,0;189,4659,-85,8114,0;193,7416,-72,8628,0;182,6257,-64,7281,0;171,5122,-72,8628,0;197,5076,-96,9247,0;206,7489,-68,6368,0;147,6764,-72,6926,0;135,8037,-65,7940,0;123,8201,-86,1752,0;135,6184,-93,0739,0;123,9950,-72,4729,0;147,5973,-86,3638,0;159,4826,-65,8525,0; C11H12O3 C1=CC=C(C=C1)* Ph CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 14 15 0 0 1 M V30 BEGIN ATOM M V30 1 C 175.78564 -85.81139 0 0 M V30 2 C 189.46585 -85.81139 0 0 CFG=1 M V30 3 C 193.74158 -72.86279 0 0 M V30 4 O 182.62575 -64.72813 0 0 M V30 5 C 171.51219 -72.86279 0 0 CFG=2 M V30 6 O 197.50755 -96.92468 0 0 M V30 7 O 206.74893 -68.6368 0 0 M V30 8 C 147.67641 -72.69263 0 0 M V30 9 C 135.80368 -65.79402 0 0 M V30 10 C 123.82014 -86.17523 0 0 M V30 11 C 135.61839 -93.07385 0 0 M V30 12 C 123.99504 -72.4729 0 0 M V30 13 C 147.59729 -86.36385 0 0 M V30 14 C 159.4826 -65.85254 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 1 2 3 M V30 3 1 3 4 M V30 4 1 4 5 M V30 5 1 5 1 M V30 6 1 2 6 CFG=3 M V30 7 2 3 7 M V30 8 2 8 9 M V30 9 1 10 11 M V30 10 1 8 13 M V30 11 1 9 12 M V30 12 2 12 10 M V30 13 2 11 13 M V30 14 1 14 8 M V30 15 1 5 14 CFG=3 M V30 END BOND M V30 END CTAB M END CVGBIKQNUITDRC-UHFFFAOYSA-N InChI=1S/C11H13S2/c1-2-5-10(6-3-1)9-11-12-7-4-8-13-11/h1-6,11H,7-9H2/q+1 C1=CC=C(C=C1)CC2SC[CH+]CS2 C1(SC[CH+]CS1)CC2=CC=CC=C2 |(371.8,-90.99,;378.52,-102.83,;392.1,-102.9,;398.89,-91.17,;392.16,-79.42,;378.56,-79.32,;359.96,-84.17,;348.03,-90.9,;336.31,-84.02,;324.52,-90.67,;324.32,-104.33,;336.03,-111.31,;348.04,-104.52,)| AuxInfo=1/0/N:10,11,12,4,13,9,3,5,7,8,1,2,6/E:(2,3)(5,6)(7,8)(12,13)/CRV:4+1/rA:13nCSCC+CSCCCCCCC/rB:s1;s2;s3;s4;s1s5;s1;s7;d8;;s10;s9d10;s8d11;/rC:371,7997,-90,9905,0;378,5234,-102,8280,0;392,1006,-102,8990,0;398,8855,-91,1655,0;392,1618,-79,4227,0;378,5585,-79,3187,0;359,9622,-84,1721,0;348,0300,-90,8958,0;336,3147,-84,0182,0;324,3174,-104,3329,0;336,0327,-111,3051,0;324,5194,-90,6737,0;348,0448,-104,5235,0; [C11H13S2]+ C1=CC=C(C=C1)* Ph + CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 13 14 0 0 0 M V30 BEGIN ATOM M V30 1 C 371.79971 -90.99049 0 0 M V30 2 S 378.52344 -102.828 0 0 M V30 3 C 392.10059 -102.899 0 0 M V30 4 C 398.8855 -91.16547 0 0 CHG=1 M V30 5 C 392.1618 -79.42267 0 0 M V30 6 S 378.55847 -79.3187 0 0 M V30 7 C 359.96222 -84.1721 0 0 M V30 8 C 348.03003 -90.8958 0 0 M V30 9 C 336.3147 -84.01825 0 0 M V30 10 C 324.31738 -104.33287 0 0 M V30 11 C 336.03271 -111.30511 0 0 M V30 12 C 324.51941 -90.67372 0 0 M V30 13 C 348.04477 -104.52351 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 1 1 6 M V30 3 1 2 3 M V30 4 1 3 4 M V30 5 1 4 5 M V30 6 1 5 6 M V30 7 1 1 7 M V30 8 2 8 9 M V30 9 1 10 11 M V30 10 1 8 13 M V30 11 1 9 12 M V30 12 2 12 10 M V30 13 2 11 13 M V30 14 1 7 8 M V30 END BOND M V30 END CTAB M END QNYBOILAKBSWFG-JTQLQIEISA-N InChI=1S/C10H12O2/c1-2-4-9(5-3-1)6-11-7-10-8-12-10/h1-5,10H,6-8H2/t10-/m0/s1 C1=CC=C(C=C1)COC[C@H]2CO2 O1C[C@@H]1COCC2=CC=CC=C2 |(416.12,-81.27,;416.22,-94.81,;428.03,-88,;439.8,-94.81,;451.64,-87.99,;463.38,-81.17,;475.23,-87.97,;486.97,-81.15,;498.82,-87.95,;498.83,-101.57,;486.99,-108.39,;475.24,-101.59,)| AuxInfo=1/0/N:10,9,11,8,12,6,4,2,7,3,5,1/E:(2,3)(4,5)/it:im/rA:12nOCC.eCOCCCCCCC/rB:s1;p1s2;s3;s4;s5;s6;s7;d8;s9;d10;d7s11;/rC:416,1240,-81,2668,0;416,2187,-94,8089,0;428,0301,-88,0032,0;439,7990,-94,8089,0;451,6365,-87,9905,0;463,3793,-81,1721,0;475,2274,-87,9721,0;475,2381,-101,5905,0;486,9915,-108,3905,0;498,8290,-101,5721,0;498,8184,-87,9537,0;486,9702,-81,1537,0; C10H12O2 C1=CC=C(C=C1)CO* OBn CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 12 13 0 0 1 M V30 BEGIN ATOM M V30 1 O 416.12402 -81.26678 0 0 M V30 2 C 416.21872 -94.8089 0 0 M V30 3 C 428.03012 -88.00319 0 0 CFG=1 M V30 4 C 439.79901 -94.8089 0 0 M V30 5 O 451.63654 -87.99049 0 0 M V30 6 C 463.37933 -81.1721 0 0 M V30 7 C 475.22742 -87.97209 0 0 M V30 8 C 475.23807 -101.59052 0 0 M V30 9 C 486.99146 -108.3905 0 0 M V30 10 C 498.82898 -101.57213 0 0 M V30 11 C 498.81836 -87.9537 0 0 M V30 12 C 486.97021 -81.1537 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 2 1 M V30 2 1 3 2 M V30 3 1 3 1 CFG=1 M V30 4 1 3 4 M V30 5 1 5 6 M V30 6 2 7 12 M V30 7 1 7 8 M V30 8 2 8 9 M V30 9 1 9 10 M V30 10 2 10 11 M V30 11 1 11 12 M V30 12 1 6 7 M V30 13 1 4 5 M V30 END BOND M V30 END CTAB M END VGVLECMZBVMPMG-GOSISDBHSA-N InChI=1S/C18H20O3/c19-17(11-15-7-3-1-4-8-15)12-18(20)14-21-13-16-9-5-2-6-10-16/h1-10,18,20H,11-14H2/t18-/m1/s1 C1=CC=C(C=C1)CC(=O)C[C@H](COCC2=CC=CC=C2)O C(C1=CC=CC=C1)C(C[C@H](COCC2=CC=CC=C2)O)=O |(237.01,-79.82,;225.17,-86.64,;213.42,-79.79,;201.62,-86.54,;201.55,-100.17,;213.4,-107.01,;225.22,-100.23,;248.75,-86.64,;260.59,-79.82,;272.33,-86.64,;284.17,-79.82,;295.91,-86.64,;307.75,-93.45,;307.74,-107.07,;319.48,-113.89,;319.47,-127.51,;307.72,-134.31,;295.88,-127.49,;295.89,-113.87,;272.33,-100.27,;248.75,-100.27,)| AuxInfo=1/0/N:8,19,9,10,18,20,11,7,17,21,1,3,15,5,6,16,2,4,12,13,14/E:(3,4)(5,6)(7,8)(9,10)/it:im/rA:21nCCCC.eCCCCCCCOOOCCCCCCC/rB:s1;s2;s3;s4;s1;d6;;s8;s7d8;s6d9;d2;N4;s5;s14;s15;s16;d17;s18;d19;d16s20;/rC:237,0062,-79,8176,0;248,7490,-86,6360,0;260,5865,-79,8176,0;272,3293,-86,6360,0;284,1668,-79,8176,0;225,1687,-86,6360,0;213,4184,-79,7932,0;201,5500,-100,1683,0;213,3951,-107,0111,0;201,6225,-86,5432,0;225,2178,-100,2288,0;248,7490,-100,2728,0;272,3293,-100,2728,0;295,9096,-86,6360,0;307,7471,-93,4544,0;307,7365,-107,0728,0;295,8884,-113,8728,0;295,8777,-127,4912,0;307,7152,-134,3096,0;319,4687,-127,5096,0;319,4793,-113,8912,0; C18H20O3 C1=CC=C(C=C1)* Ph,C1=CC=C(C=C1)CO* OBn CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 21 22 0 0 1 M V30 BEGIN ATOM M V30 1 C 237.00621 -79.8176 0 0 M V30 2 C 248.74902 -86.636 0 0 M V30 3 C 260.58652 -79.8176 0 0 M V30 4 C 272.32932 -86.636 0 0 CFG=1 M V30 5 C 284.16681 -79.8176 0 0 M V30 6 C 225.16872 -86.636 0 0 M V30 7 C 213.41838 -79.7932 0 0 M V30 8 C 201.55002 -100.16832 0 0 M V30 9 C 213.39508 -107.01112 0 0 M V30 10 C 201.62245 -86.54317 0 0 M V30 11 C 225.21783 -100.22879 0 0 M V30 12 O 248.74902 -100.2728 0 0 M V30 13 O 272.32932 -100.2728 0 0 M V30 14 O 295.90961 -86.636 0 0 M V30 15 C 307.74713 -93.45439 0 0 M V30 16 C 307.73651 -107.07281 0 0 M V30 17 C 295.88837 -113.8728 0 0 M V30 18 C 295.87775 -127.49121 0 0 M V30 19 C 307.71524 -134.3096 0 0 M V30 20 C 319.46869 -127.5096 0 0 M V30 21 C 319.47931 -113.89119 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 6 7 M V30 2 1 8 9 M V30 3 1 6 11 M V30 4 1 7 10 M V30 5 2 10 8 M V30 6 2 9 11 M V30 7 1 6 1 M V30 8 1 1 2 M V30 9 1 2 3 M V30 10 1 3 4 M V30 11 1 4 5 M V30 12 1 14 15 M V30 13 2 16 21 M V30 14 1 16 17 M V30 15 2 17 18 M V30 16 1 18 19 M V30 17 2 19 20 M V30 18 1 20 21 M V30 19 1 15 16 M V30 20 1 5 14 M V30 21 2 2 12 M V30 22 1 4 13 CFG=3 M V30 END BOND M V30 END CTAB M END ZYNHKUNSVHIICK-WOJBJXKFSA-N InChI=1S/C21H26O3/c1-21(2)23-19(13-17-9-5-3-6-10-17)14-20(24-21)16-22-15-18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/t19-,20-/m1/s1 CC1(C)O[C@H](CC2=CC=CC=C2)C[C@H](COCC3=CC=CC=C3)O1 C1(C)(C)O[C@@H](C[C@H](COCC2=CC=CC=C2)O1)CC3=CC=CC=C3 |(139.27,-106.52,;127.34,-113.34,;150.99,-113.36,;127.24,-99.8,;127.37,-86.23,;139.26,-79.44,;151,-86.26,;162.85,-79.34,;174.59,-86.16,;186.43,-92.98,;186.42,-106.6,;198.16,-113.42,;198.15,-127.04,;186.4,-133.74,;174.56,-127.02,;174.57,-113.4,;150.83,-99.7,;115.69,-79.34,;103.85,-86.16,;92.1,-79.32,;80.31,-86.07,;80.24,-99.69,;92.08,-106.54,;103.9,-99.76,)| AuxInfo=1/0/N:2,3,11,20,12,13,19,21,14,10,18,22,7,5,16,8,9,17,6,4,1,15,23,24/E:(1,2)(5,6)(7,8)(9,10)(11,12)/it:im/rA:24nCCCC.eCC.oCCCCCCCCOCCCCCCCOO/rB:s1;s1;;s4;s5;s6;s4;s7;d9;;s11;s10d11;s9d12;s8;s15;s16;s17;d18;s19;d20;d17s21;s1N6;s1N4;/rC:139,2717,-106,5230,0;127,3395,-113,3414,0;150,9911,-113,3633,0;151,0032,-86,2556,0;139,2604,-79,4372,0;127,3679,-86,2253,0;115,6914,-79,3441,0;162,8520,-79,3441,0;103,8539,-86,1625,0;92,1036,-79,3197,0;80,2352,-99,6948,0;92,0803,-106,5376,0;80,3077,-86,0697,0;103,9030,-99,7553,0;174,5948,-86,1625,0;186,4323,-92,9809,0;186,4217,-106,5993,0;174,5736,-113,3993,0;174,5630,-127,0177,0;186,4004,-133,7414,0;198,1539,-127,0361,0;198,1645,-113,4177,0;127,2448,-99,7993,0;150,8251,-99,7046,0; C21H26O3 C1=CC=C(C=C1)* Ph,C1=CC=C(C=C1)CO* OBn CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 24 26 0 0 1 M V30 BEGIN ATOM M V30 1 C 139.27171 -106.52299 0 0 M V30 2 C 127.33952 -113.3414 0 0 M V30 3 C 150.99113 -113.36331 0 0 M V30 4 C 151.00319 -86.2556 0 0 CFG=1 M V30 5 C 139.26041 -79.43719 0 0 M V30 6 C 127.36786 -86.22527 0 0 CFG=2 M V30 7 C 115.69142 -79.3441 0 0 M V30 8 C 162.85202 -79.3441 0 0 M V30 9 C 103.85393 -86.16249 0 0 M V30 10 C 92.10359 -79.31969 0 0 M V30 11 C 80.23521 -99.69482 0 0 M V30 12 C 92.08026 -106.53761 0 0 M V30 13 C 80.30768 -86.06967 0 0 M V30 14 C 103.90303 -99.75528 0 0 M V30 15 O 174.59482 -86.16249 0 0 M V30 16 C 186.43231 -92.9809 0 0 M V30 17 C 186.42168 -106.59929 0 0 M V30 18 C 174.57358 -113.39931 0 0 M V30 19 C 174.56296 -127.01772 0 0 M V30 20 C 186.40044 -133.74141 0 0 M V30 21 C 198.15387 -127.03609 0 0 M V30 22 C 198.16449 -113.41769 0 0 M V30 23 O 127.24481 -99.79929 0 0 M V30 24 O 150.82513 -99.70461 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 1 1 3 M V30 3 1 23 1 M V30 4 1 1 24 M V30 5 1 4 5 M V30 6 1 5 6 M V30 7 2 9 10 M V30 8 1 11 12 M V30 9 1 9 14 M V30 10 1 10 13 M V30 11 2 13 11 M V30 12 2 12 14 M V30 13 1 9 7 M V30 14 1 7 6 M V30 15 1 4 8 M V30 16 1 15 16 M V30 17 2 17 22 M V30 18 1 17 18 M V30 19 2 18 19 M V30 20 1 19 20 M V30 21 2 20 21 M V30 22 1 21 22 M V30 23 1 16 17 M V30 24 1 8 15 M V30 25 1 6 23 CFG=3 M V30 26 1 4 24 CFG=3 M V30 END BOND M V30 END CTAB M END DTUQWGWMVIHBKE-UHFFFAOYSA-N InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 C1=CC=C(C=C1)CC=O C1=CC=CC(=C1)CC=O |(50.6,-34.52,;50.58,-46.99,;61.3,-53.28,;72.12,-46.98,;72.07,-34.46,;61.27,-28.31,;82.83,-28.2,;93.65,-34.36,;93.72,-46.76,)| AuxInfo=1/0/N:2,1,3,6,4,7,8,5,9/E:(2,3)(4,5)/rA:9nCCCCCCCCO/rB:d1;s2;d3;s4;s1d5;s5;s7;d8;/rC:50,5985,-34,5241,0;50,5758,-46,9881,0;61,2981,-53,2806,0;72,1188,-46,9805,0;72,0734,-34,4560,0;61,2678,-28,3073,0;82,8335,-28,2013,0;93,6467,-34,3576,0;93,7216,-46,7593,0; C8H8O C(=O)* CHO CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 9 9 0 0 0 M V30 BEGIN ATOM M V30 1 C 50.5985 -34.52414 0 0 M V30 2 C 50.57578 -46.98805 0 0 M V30 3 C 61.29807 -53.28059 0 0 M V30 4 C 72.1188 -46.98047 0 0 M V30 5 C 72.07336 -34.45601 0 0 M V30 6 C 61.26778 -28.30734 0 0 M V30 7 C 82.83351 -28.20131 0 0 M V30 8 C 93.64667 -34.35756 0 0 M V30 9 O 93.72156 -46.75932 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 2 8 9 M V30 9 1 7 8 M V30 END BOND M V30 END CTAB M END IPXQFDOGAIGBNE-CHWSQXEVSA-N InChI=1S/C14H20O3/c1-14(2)16-12(9-13(10-15)17-14)8-11-6-4-3-5-7-11/h3-7,12-13,15H,8-10H2,1-2H3/t12-,13-/m1/s1 CC1(C)O[C@H](CC2=CC=CC=C2)C[C@H](CO)O1 C1=CC=CC(=C1)C[C@@H]2C[C@H](CO)OC(O2)(C)C |(49.27,-193.03,;49.25,-205.49,;60.05,-211.71,;70.87,-205.49,;70.82,-192.96,;60.02,-186.74,;81.58,-186.71,;92.37,-192.83,;103.08,-186.61,;113.83,-192.67,;124.65,-186.51,;135.48,-192.67,;113.85,-205.12,;103.14,-211.33,;92.42,-205.17,;92.31,-217.41,;113.89,-217.49,)| AuxInfo=1/0/N:15,16,2,1,3,6,4,7,9,8,5,10,14,12,17,11,13/E:(1,2)(4,5)(6,7)/it:im/rA:17nCCCCCCCCCC.eOCOC.oCCO/rB:d1;s2;d3;s4;s1d5;s5;;;s7s9;N10;s11;s12;s8s9n13;s12;s12;s8;/rC:49,2733,-193,0300,0;49,2506,-205,4940,0;60,0486,-211,7108,0;70,8694,-205,4864,0;70,8239,-192,9619,0;60,0184,-186,7375,0;81,5841,-186,7072,0;124,6550,-186,5104,0;103,0817,-186,6088,0;92,3745,-192,8256,0;92,4200,-205,1684,0;103,1423,-211,3322,0;113,8494,-205,1154,0;113,8343,-192,6666,0;92,3140,-217,4127,0;113,8948,-217,4884,0;135,4757,-192,6742,0; C14H20O3 CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 17 18 0 0 1 M V30 BEGIN ATOM M V30 1 C 49.27335 -193.03004 0 0 M V30 2 C 49.25064 -205.49396 0 0 M V30 3 C 60.04865 -211.71077 0 0 M V30 4 C 70.86938 -205.48639 0 0 M V30 5 C 70.82394 -192.96191 0 0 M V30 6 C 60.01837 -186.73753 0 0 M V30 7 C 81.58411 -186.70723 0 0 M V30 8 C 124.655 -186.51036 0 0 M V30 9 C 103.0817 -186.60881 0 0 M V30 10 C 92.37454 -192.82561 0 0 CFG=1 M V30 11 O 92.41997 -205.16835 0 0 M V30 12 C 103.14227 -211.33215 0 0 M V30 13 O 113.84943 -205.11536 0 0 M V30 14 C 113.83427 -192.6666 0 0 CFG=2 M V30 15 C 92.31396 -217.41267 0 0 M V30 16 C 113.89484 -217.48839 0 0 M V30 17 O 135.47572 -192.67416 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 10 M V30 9 1 14 8 M V30 10 1 8 17 M V30 11 1 9 10 M V30 12 1 9 14 M V30 13 1 10 11 CFG=3 M V30 14 1 11 12 M V30 15 1 12 13 M V30 16 1 14 13 CFG=3 M V30 17 1 12 15 M V30 18 1 12 16 M V30 END BOND M V30 END CTAB M END MSKJIOLAEMWMFR-HXUWFJFHSA-N InChI=1S/C21H26O2S2/c22-20(17-23-16-19-10-5-2-6-11-19)15-21(24-12-7-13-25-21)14-18-8-3-1-4-9-18/h1-6,8-11,20,22H,7,12-17H2/t20-/m1/s1 C1=CC=C(C=C1)CC2(C[C@H](COCC3=CC=CC=C3)O)SCCCS2 S1CCCSC1(CC=2C=CC=CC2)C[C@H](COCC3=CC=CC=C3)O |(82.47,-89.9,;82.47,-102.39,;93.21,-108.52,;103.95,-102.39,;103.95,-89.9,;93.21,-83.61,;82.34,-77.52,;71.58,-83.77,;71.63,-96.29,;60.88,-102.52,;50.08,-96.3,;50.11,-83.84,;60.85,-77.62,;103.91,-77.42,;114.73,-83.58,;125.49,-77.32,;136.23,-83.56,;146.99,-77.38,;157.71,-83.61,;157.68,-96.01,;168.41,-102.24,;179.16,-96.07,;179.19,-83.67,;168.47,-77.44,;114.79,-96.08,)| AuxInfo=1/0/N:8,22,7,9,21,23,3,12,10,20,24,2,4,13,14,25,16,11,19,15,6,17,18,1,5/E:(3,4)(5,6)(8,9)(10,11)(12,13)(24,25)/it:im/rA:25nSCCCSCCCCCCCCCC.eCOOCCCCCCC/rB:s1;s2;s3;s4;s1s5;;d7;s8;d9;s10;s7d11;s6s11;s6;s14;s15;N15;s16;;d19;s20;d21;s22;s19d23;s18s19;/rC:82,4701,-89,8961,0;82,4701,-102,3903,0;93,2075,-108,5239,0;103,9525,-102,3903,0;103,9525,-89,8961,0;93,2075,-83,6112,0;50,1063,-83,8384,0;50,0836,-96,3023,0;60,8816,-102,5191,0;71,6266,-96,2947,0;71,5812,-83,7702,0;60,8513,-77,6216,0;82,3413,-77,5155,0;103,9146,-77,4171,0;114,7278,-83,5809,0;125,4879,-77,3187,0;114,7884,-96,0751,0;136,2330,-83,5582,0;157,7138,-83,6119,0;157,6827,-96,0139,0;168,4077,-102,2417,0;179,1636,-96,0676,0;179,1946,-83,6657,0;168,4697,-77,4378,0;146,9889,-77,3841,0; C21H26O2S2 C1=CC=C(C=C1)CO* OBn CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 25 27 0 0 1 M V30 BEGIN ATOM M V30 1 S 82.47006 -89.89615 0 0 M V30 2 C 82.47006 -102.39034 0 0 M V30 3 C 93.20749 -108.52386 0 0 M V30 4 C 103.9525 -102.39034 0 0 M V30 5 S 103.9525 -89.89615 0 0 M V30 6 C 93.20749 -83.61119 0 0 M V30 7 C 50.10629 -83.83836 0 0 M V30 8 C 50.08357 -96.30228 0 0 M V30 9 C 60.88161 -102.51907 0 0 M V30 10 C 71.6266 -96.29469 0 0 M V30 11 C 71.58118 -83.7702 0 0 M V30 12 C 60.8513 -77.62155 0 0 M V30 13 C 82.34132 -77.51553 0 0 M V30 14 C 103.91463 -77.4171 0 0 M V30 15 C 114.7278 -83.5809 0 0 CFG=1 M V30 16 C 125.48793 -77.31866 0 0 M V30 17 O 114.78838 -96.0751 0 0 M V30 18 O 136.23296 -83.55818 0 0 M V30 19 C 157.71378 -83.61192 0 0 M V30 20 C 157.68274 -96.01389 0 0 M V30 21 C 168.40765 -102.24174 0 0 M V30 22 C 179.16359 -96.06763 0 0 M V30 23 C 179.19461 -83.66566 0 0 M V30 24 C 168.46971 -77.43782 0 0 M V30 25 C 146.98889 -77.38408 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 1 1 2 M V30 2 1 1 6 M V30 3 1 2 3 M V30 4 1 3 4 M V30 5 1 4 5 M V30 6 1 5 6 M V30 7 2 7 8 M V30 8 1 8 9 M V30 9 2 9 10 M V30 10 1 10 11 M V30 11 2 11 12 M V30 12 1 12 7 M V30 13 1 11 13 M V30 14 1 13 6 M V30 15 1 6 14 M V30 16 1 14 15 M V30 17 1 15 16 M V30 18 1 18 25 M V30 19 2 19 20 M V30 20 1 20 21 M V30 21 2 21 22 M V30 22 1 22 23 M V30 23 2 23 24 M V30 24 1 19 24 M V30 25 1 19 25 M V30 26 1 16 18 M V30 27 1 15 17 CFG=3 M V30 END BOND M V30 END CTAB M END NBGQAPJQVZTDQE-UHFFFAOYSA-N InChI=1S/C11H14S2/c1-2-5-10(6-3-1)9-11-12-7-4-8-13-11/h1-3,5-6,11H,4,7-9H2 C1=CC=C(C=C1)CC2SCCCS2 C1=CC=CC(=C1)CC2SCCCS2 |(214.31,-34.31,;214.65,-46.77,;225.55,-52.74,;236.19,-46.21,;235.85,-33.69,;224.94,-27.79,;246.51,-27.14,;257.52,-33.11,;257.78,-45.67,;268.73,-51.64,;279.43,-45.14,;279.12,-32.61,;268.11,-26.58,)| AuxInfo=1/0/N:2,1,3,11,6,4,10,12,7,5,8,9,13/E:(2,3)(5,6)(7,8)(12,13)/rA:13nCCCCCCCCSCCCS/rB:d1;s2;d3;s4;s1d5;s5;s7;s8;s9;s10;s11;s8s12;/rC:214,3097,-34,3128,0;214,6505,-46,7691,0;225,5469,-52,7437,0;236,1859,-46,2088,0;235,8452,-33,6919,0;224,9411,-27,7855,0;246,5145,-27,1419,0;257,5169,-33,1088,0;257,7820,-45,6712,0;268,7314,-51,6381,0;279,4310,-45,1411,0;279,1205,-32,6091,0;268,1105,-26,5816,0; C11H14S2 CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 13 14 0 0 0 M V30 BEGIN ATOM M V30 1 C 214.30971 -34.31282 0 0 M V30 2 C 214.65047 -46.76915 0 0 M V30 3 C 225.54692 -52.74365 0 0 M V30 4 C 236.18591 -46.2088 0 0 M V30 5 C 235.84517 -33.69189 0 0 M V30 6 C 224.94115 -27.78554 0 0 M V30 7 C 246.51445 -27.14191 0 0 M V30 8 C 257.51691 -33.10883 0 0 M V30 9 S 257.78195 -45.67119 0 0 M V30 10 C 268.73138 -51.63811 0 0 M V30 11 C 279.43097 -45.14113 0 0 M V30 12 C 279.12051 -32.60905 0 0 M V30 13 S 268.11047 -26.58156 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 8 M V30 9 1 8 9 M V30 10 1 8 13 M V30 11 1 9 10 M V30 12 1 10 11 M V30 13 1 11 12 M V30 14 1 12 13 M V30 END BOND M V30 END CTAB M END SXOORWOJUXFBFT-QZTJIDSGSA-N InChI=1S/C18H22O3/c19-17(11-15-7-3-1-4-8-15)12-18(20)14-21-13-16-9-5-2-6-10-16/h1-10,17-20H,11-14H2/t17-,18-/m1/s1 C1=CC=C(C=C1)C[C@H](C[C@H](COCC2=CC=CC=C2)O)O C1=CC=CC(=C1)C[C@H](C[C@H](COCC2=CC=CC=C2)O)O |(49.65,-136.28,;49.63,-148.74,;60.43,-155.03,;71.17,-148.73,;71.13,-136.21,;60.4,-130.06,;81.89,-129.95,;92.7,-136.19,;103.46,-129.85,;114.27,-136.09,;125.03,-129.83,;135.78,-136,;146.5,-129.77,;157.26,-135.94,;157.29,-148.34,;168.05,-154.51,;178.77,-148.28,;178.74,-135.88,;167.98,-129.71,;114.33,-148.51,;92.75,-148.6,)| AuxInfo=1/0/N:2,18,1,3,17,19,6,4,16,20,7,9,21,11,5,15,8,10,12,13,14/E:(3,4)(5,6)(7,8)(9,10)/it:im/rA:21nCCCCCCCC.eCC.eCOOOCCCCCCC/rB:d1;s2;d3;s4;s1d5;s5;s7;s8;s9;s10;N8;N10;s11;;d15;s16;d17;s18;s15d19;s14s15;/rC:49,6520,-136,2761,0;49,6292,-148,7400,0;60,4272,-155,0326,0;71,1723,-148,7325,0;71,1268,-136,2080,0;60,3970,-130,0593,0;81,8870,-129,9533,0;92,7001,-136,1853,0;103,4603,-129,8549,0;114,2735,-136,0944,0;125,0336,-129,8321,0;92,7532,-148,6037,0;114,3340,-148,5129,0;135,7786,-135,9959,0;157,2594,-135,9361,0;157,2940,-148,3381,0;168,0516,-154,5092,0;178,7748,-148,2783,0;178,7402,-135,8763,0;167,9826,-129,7053,0;146,5018,-129,7651,0; C18H22O3 C1=CC=C(C=C1)CO* OBn CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 21 22 0 0 1 M V30 BEGIN ATOM M V30 1 C 49.65198 -136.27612 0 0 M V30 2 C 49.62924 -148.74004 0 0 M V30 3 C 60.42725 -155.03256 0 0 M V30 4 C 71.17227 -148.73245 0 0 M V30 5 C 71.12685 -136.20796 0 0 M V30 6 C 60.39697 -130.05931 0 0 M V30 7 C 81.88698 -129.95329 0 0 M V30 8 C 92.70015 -136.18526 0 0 CFG=1 M V30 9 C 103.4603 -129.85486 0 0 M V30 10 C 114.27347 -136.09438 0 0 CFG=1 M V30 11 C 125.03362 -129.83214 0 0 M V30 12 O 92.75316 -148.60373 0 0 M V30 13 O 114.33403 -148.51286 0 0 M V30 14 O 135.77861 -135.99594 0 0 M V30 15 C 157.25941 -135.93614 0 0 M V30 16 C 157.29396 -148.33809 0 0 M V30 17 C 168.05164 -154.50917 0 0 M V30 18 C 178.77477 -148.27827 0 0 M V30 19 C 178.74023 -135.87633 0 0 M V30 20 C 167.98256 -129.70526 0 0 M V30 21 C 146.50177 -129.76508 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 8 M V30 9 1 8 9 M V30 10 1 9 10 M V30 11 1 10 11 M V30 12 1 14 21 M V30 13 2 15 16 M V30 14 1 16 17 M V30 15 2 17 18 M V30 16 1 18 19 M V30 17 2 19 20 M V30 18 1 15 20 M V30 19 1 15 21 M V30 20 1 11 14 M V30 21 1 8 12 CFG=3 M V30 22 1 10 13 CFG=3 M V30 END BOND M V30 END CTAB M END IPXQFDOGAIGBNE-QWHCGFSZSA-N InChI=1S/C14H20O3/c1-14(2)16-12(9-13(10-15)17-14)8-11-6-4-3-5-7-11/h3-7,12-13,15H,8-10H2,1-2H3/t12-,13+/m0/s1 CC1(C)O[C@@H](CC2=CC=CC=C2)C[C@H](CO)O1 C1=CC=CC(=C1)C[C@H]2C[C@H](CO)OC(O2)(C)C |(14.62,-141.8,;14.6,-154.24,;25.38,-160.44,;36.18,-154.23,;36.13,-141.73,;25.34,-135.52,;46.87,-135.48,;57.65,-141.59,;68.34,-135.39,;79.07,-141.43,;89.88,-135.29,;100.67,-141.44,;79.08,-153.86,;68.4,-160.07,;57.69,-153.91,;57.58,-166.14,;79.13,-166.21,)| AuxInfo=1/0/N:15,16,2,1,3,6,4,7,9,8,5,10,14,12,17,11,13/E:(1,2)(4,5)(6,7)/it:im/rA:17nCCCCCCCCCC.oOCOC.oCCO/rB:d1;s2;d3;s4;s1d5;s5;;;s7s9;P10;s11;s12;s8s9n13;s12;s12;s8;/rC:14,6213,-141,7972,0;14,6003,-154,2374,0;25,3764,-160,4427,0;36,1821,-154,2287,0;36,1303,-141,7313,0;25,3436,-135,5182,0;46,8719,-135,4839,0;89,8756,-135,2885,0;68,3360,-135,3862,0;57,6474,-141,5896,0;57,6920,-153,9120,0;68,3953,-160,0679,0;79,0839,-153,8645,0;79,0691,-141,4296,0;57,5839,-166,1387,0;79,1278,-166,2143,0;100,6736,-141,4382,0; C14H20O3 CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 17 18 0 0 1 M V30 BEGIN ATOM M V30 1 C 14.62126 -141.7972 0 0 M V30 2 C 14.60033 -154.23737 0 0 M V30 3 C 25.3764 -160.44272 0 0 M V30 4 C 36.18211 -154.22868 0 0 M V30 5 C 36.13026 -141.73128 0 0 M V30 6 C 25.34363 -135.51817 0 0 M V30 7 C 46.87187 -135.48389 0 0 M V30 8 C 89.87558 -135.28851 0 0 M V30 9 C 68.33595 -135.38618 0 0 M V30 10 C 57.64742 -141.58957 0 0 CFG=2 M V30 11 O 57.692 -153.91196 0 0 M V30 12 C 68.39534 -160.06789 0 0 M V30 13 O 79.08388 -153.86449 0 0 M V30 14 C 79.06908 -141.42961 0 0 CFG=2 M V30 15 C 57.58391 -166.13873 0 0 M V30 16 C 79.12781 -166.21432 0 0 M V30 17 O 100.67363 -141.4382 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 10 M V30 9 1 14 8 M V30 10 1 8 17 M V30 11 1 9 10 M V30 12 1 9 14 M V30 13 1 10 11 CFG=1 M V30 14 1 11 12 M V30 15 1 12 13 M V30 16 1 14 13 CFG=3 M V30 17 1 12 15 M V30 18 1 12 16 M V30 END BOND M V30 END CTAB M END SXOORWOJUXFBFT-ZWKOTPCHSA-N InChI=1S/C18H22O3/c19-17(11-15-7-3-1-4-8-15)12-18(20)14-21-13-16-9-5-2-6-10-16/h1-10,17-20H,11-14H2/t17-,18+/m0/s1 C1=CC=C(C=C1)C[C@@H](C[C@H](COCC2=CC=CC=C2)O)O C1=CC=CC(=C1)C[C@@H](C[C@H](COCC2=CC=CC=C2)O)O |(126.41,-21,;126.39,-33.89,;137.54,-40.33,;148.65,-33.89,;148.6,-20.93,;137.51,-14.57,;159.81,-14.62,;170.61,-20.85,;181.35,-14.52,;192.15,-20.75,;202.89,-14.5,;213.61,-20.65,;224.39,-26.79,;224.45,-39.27,;235.25,-45.41,;235.3,-57.81,;224.56,-64.06,;213.76,-57.91,;213.71,-45.51,;192.2,-33.15,;170.66,-33.24,)| AuxInfo=1/0/N:2,19,1,3,18,20,6,4,17,21,7,9,15,11,5,16,8,10,12,13,14/E:(3,4)(5,6)(7,8)(9,10)/it:im/rA:21nCCCCCCCC.oCC.eCOOOCCCCCCC/rB:d1;s2;d3;s4;s1d5;s5;s7;s8;s9;s10;P8;N10;s11;s14;s15;s16;d17;s18;d19;d16s20;/rC:126,4105,-21,0008,0;126,3895,-33,8945,0;137,5435,-40,3267,0;148,6516,-33,8859,0;148,5998,-20,9349,0;137,5108,-14,5706,0;159,8097,-14,6209,0;170,6077,-20,8462,0;181,3493,-14,5232,0;192,1473,-20,7485,0;202,8890,-14,5011,0;170,6641,-33,2433,0;192,2037,-33,1456,0;213,6114,-20,6508,0;224,3909,-26,7924,0;224,4473,-39,2651,0;213,7057,-45,5125,0;213,7621,-57,9095,0;224,5601,-64,0592,0;235,3017,-57,8118,0;235,2453,-45,4147,0; C18H22O3 C1=CC=C(C=C1)CO* OBn CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 21 22 0 0 1 M V30 BEGIN ATOM M V30 1 C 126.41046 -21.00082 0 0 M V30 2 C 126.38951 -33.89455 0 0 M V30 3 C 137.54355 -40.32669 0 0 M V30 4 C 148.65161 -33.88588 0 0 M V30 5 C 148.59979 -20.93492 0 0 M V30 6 C 137.51079 -14.57059 0 0 M V30 7 C 159.80968 -14.62094 0 0 M V30 8 C 170.60771 -20.84621 0 0 CFG=2 M V30 9 C 181.34932 -14.52322 0 0 M V30 10 C 192.14734 -20.74852 0 0 CFG=1 M V30 11 C 202.88896 -14.50113 0 0 M V30 12 O 170.66409 -33.2433 0 0 M V30 13 O 192.20374 -33.14565 0 0 M V30 14 O 213.6114 -20.65085 0 0 M V30 15 C 224.3909 -26.79239 0 0 M V30 16 C 224.4473 -39.26506 0 0 M V30 17 C 213.70567 -45.51245 0 0 M V30 18 C 213.76207 -57.90955 0 0 M V30 19 C 224.56009 -64.05923 0 0 M V30 20 C 235.3017 -57.81184 0 0 M V30 21 C 235.24532 -45.41475 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 7 8 M V30 8 1 8 9 M V30 9 1 9 10 M V30 10 1 10 11 M V30 11 1 14 15 M V30 12 2 16 21 M V30 13 1 16 17 M V30 14 2 17 18 M V30 15 1 18 19 M V30 16 2 19 20 M V30 17 1 20 21 M V30 18 1 15 16 M V30 19 1 11 14 M V30 20 1 8 12 CFG=1 M V30 21 1 10 13 CFG=3 M V30 22 1 7 5 M V30 END BOND M V30 END CTAB M END ZYNHKUNSVHIICK-VQTJNVASSA-N InChI=1S/C21H26O3/c1-21(2)23-19(13-17-9-5-3-6-10-17)14-20(24-21)16-22-15-18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/t19-,20+/m0/s1 CC1(C)O[C@@H](CC2=CC=CC=C2)C[C@H](COCC3=CC=CC=C3)O1 C1=CC=CC(=C1)C[C@H]2C[C@H](COCC3=CC=CC=C3)OC(O2)(C)C |(75.35,-74.16,;75.33,-86.6,;86.11,-92.8,;96.91,-86.59,;96.86,-74.09,;86.08,-67.95,;107.6,-67.84,;118.38,-73.95,;129.07,-67.75,;139.8,-73.87,;150.61,-67.65,;161.41,-73.87,;172.19,-80.02,;172.17,-92.41,;182.96,-98.64,;183.02,-111.04,;172.28,-117.28,;161.48,-111.13,;161.5,-98.66,;139.82,-86.22,;129.13,-92.43,;118.42,-86.27,;118.32,-98.57,;139.86,-98.57,)| AuxInfo=1/0/N:15,16,2,22,1,3,21,23,6,4,20,24,7,9,18,8,5,19,10,14,12,17,11,13/E:(1,2)(5,6)(7,8)(9,10)(11,12)/it:im/rA:24nCCCCCCCCCC.oOCOC.oCCOCCCCCCC/rB:d1;s2;d3;s4;s1d5;s5;;;s7s9;P10;s11;s12;s8s9n13;s12;s12;s8;s17;s18;s19;d20;s21;d22;d19s23;/rC:75,3542,-74,1575,0;75,3332,-86,5977,0;86,1093,-92,8031,0;96,9150,-86,5890,0;96,8632,-74,0916,0;86,0765,-67,9541,0;107,6048,-67,8442,0;150,6085,-67,6489,0;129,0688,-67,7465,0;118,3803,-73,9499,0;118,4249,-86,2723,0;129,1282,-92,4282,0;139,8168,-86,2249,0;139,8020,-73,8655,0;118,3168,-98,5747,0;139,8607,-98,5747,0;161,4065,-73,8741,0;172,1861,-80,0156,0;172,1669,-92,4128,0;161,5008,-98,6602,0;161,4816,-111,1328,0;172,2797,-117,2825,0;183,0213,-111,0351,0;182,9649,-98,6380,0; C21H26O3 C1=CC=C(C=C1)CO* OBn CDK 04212621322D 0 0 0 0 0 999 V3000 M V30 BEGIN CTAB M V30 COUNTS 24 26 0 0 1 M V30 BEGIN ATOM M V30 1 C 75.35416 -74.15755 0 0 M V30 2 C 75.33322 -86.5977 0 0 M V30 3 C 86.10928 -92.80305 0 0 M V30 4 C 96.91499 -86.58904 0 0 M V30 5 C 96.86316 -74.09161 0 0 M V30 6 C 86.07652 -67.9541 0 0 M V30 7 C 107.60477 -67.84422 0 0 M V30 8 C 150.60846 -67.64886 0 0 M V30 9 C 129.06883 -67.74652 0 0 M V30 10 C 118.38029 -73.94992 0 0 CFG=2 M V30 11 O 118.4249 -86.27229 0 0 M V30 12 C 129.12822 -92.42824 0 0 M V30 13 O 139.81676 -86.22487 0 0 M V30 14 C 139.80197 -73.86554 0 0 CFG=2 M V30 15 C 118.31679 -98.57468 0 0 M V30 16 C 139.8607 -98.57468 0 0 M V30 17 O 161.40652 -73.87411 0 0 M V30 18 C 172.18608 -80.01564 0 0 M V30 19 C 172.16689 -92.41277 0 0 M V30 20 C 161.50082 -98.66016 0 0 M V30 21 C 161.48164 -111.13284 0 0 M V30 22 C 172.27968 -117.28253 0 0 M V30 23 C 183.0213 -111.03513 0 0 M V30 24 C 182.9649 -98.63805 0 0 M V30 END ATOM M V30 BEGIN BOND M V30 1 2 1 2 M V30 2 1 2 3 M V30 3 2 3 4 M V30 4 1 4 5 M V30 5 2 5 6 M V30 6 1 6 1 M V30 7 1 5 7 M V30 8 1 7 10 M V30 9 1 14 8 M V30 10 1 17 18 M V30 11 2 19 24 M V30 12 1 19 20 M V30 13 2 20 21 M V30 14 1 21 22 M V30 15 2 22 23 M V30 16 1 23 24 M V30 17 1 18 19 M V30 18 1 8 17 M V30 19 1 9 10 M V30 20 1 9 14 M V30 21 1 10 11 CFG=1 M V30 22 1 11 12 M V30 23 1 12 13 M V30 24 1 14 13 CFG=3 M V30 25 1 12 15 M V30 26 1 12 16 M V30 END BOND M V30 END CTAB M END Experimental section and analytical data. <chunk>Acknowledgements</chunk> R. S. thanks CSIR, S. K. D thanks UGC, New Delhi for the award of fellowships. Nat. Prod. Rep. (and references cited therein) J. Antibiot. Tetrahedron: Asymmetry Tetrahedron: Asymmetry Heterocycles Tetrahedron Lett. Tetrahedron Lett. Tetrahedron Lett. Tetrahedron: Asymmetry Tetrahedron: Asymmetry Tetrahedron: Asymmetry Tetrahedron Lett. Tetrahedron Lett. Tetrahedron Lett. J. Am. Chem. Soc. Tetrahedron Lett. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)