Beilstein J. Org. Chem.2023,19, 139–157, doi:10.3762/bjoc.19.14
-capro-β-CD (MW = 1813 g/mol) and poly-β-CD-C6 (MW = 3178 g/mol) seen in Figure 9 were synthetized, purified, and characterized in the Institute for Chemical Research (CSIC-University of Sevilla, Spain) as previously reported [9][25][50].
(S)-(+)-Camptothecin (95% HPLC powder, MW: 348.35 g/mol) was
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Graphical Abstract
Figure 1:
In vitro release profile of CPT from nanoparticle formulations (n = 3, ± SD).
Beilstein J. Org. Chem.2015,11, 147–154, doi:10.3762/bjoc.11.14
, ICMPE, CNRS and University Paris Est, 2 rue Henri Dunant, 94320 Thiais, France 10.3762/bjoc.11.14 Abstract Novel (S)-camptothecin–dextran polymers were obtained by “click” grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were
prepared with a degree of substitution of (S)-camptothecin between 3.1 and 10.2%. The binding properties with β-cyclodextrin and β-cyclodextrin polymers were measured by isothermal titration calorimetry and fluorescence spectroscopy, showing no binding with β-cyclodextrin but high binding with β
-cyclodextrin polymers. In aqueous solution nanoparticles were formed from association between the (S)-camptothecin–dextran polymers and the β-cyclodextrin polymers.
Keywords: (S)-camptothecin; cyclodextrins; fluorescence; nanoparticles; ITC; Introduction
Cancer remains to be the major cause of mortality in
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Graphical Abstract
Scheme 1:
Reaction scheme for synthesis of azide-modified (S)-camptothecin.