Beilstein J. Org. Chem.2014,10, 34–114, doi:10.3762/bjoc.10.6
.10.6 Abstract The present review describes the current status of synthetic five and six-membered cyclic peroxides such as 1,2-dioxolanes, 1,2,4-trioxolanes (ozonides), 1,2-dioxanes, 1,2-dioxenes, 1,2,4-trioxanes, and 1,2,4,5-tetraoxanes. The literature from 2000 onwards is surveyed to provide an update
, and antitumor agents.
Keywords: cyclic peroxides; 1,2-dioxanes; 1,2-dioxenes; 1,2-dioxolanes; ozonides; 1,2,4,5-tetraoxanes; 1,2,4-trioxanes; 1,2,4-trioxolanes; Introduction
Approaches to the synthesis of five and six-membered cyclic peroxides, such as 1,2-dioxolanes I, 1,2,4-trioxolanes (ozonides
corresponding esters 161a and 161b, which were hydrolyzed to prepare the target plakinic acids (Scheme 40).
2. Synthesis of 1,2,4-trioxolanes (ozonides)
The currently most widely used methods for the synthesis of 1,2,4-trioxolanes are based on reactions of ozone with unsaturated compounds, such as the