Beilstein J. Org. Chem.2016,12, 1647–1748, doi:10.3762/bjoc.12.162
-diketones 283 (Scheme 84) [359][360].
The Kornblum–DeLaMare rearrangement of 1,2-dioxenes 284 [361], 1,2-dioxanes 286 [362], and tert-butyl peroxides 288 [330][363] produces 1,4-dicarbonyl compounds 285, 287, and 289, respectively (Scheme 85). These compounds are versatile starting substrates for the
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Graphical Abstract
Figure 1:
The named transformations considered in this review.
Beilstein J. Org. Chem.2014,10, 34–114, doi:10.3762/bjoc.10.6
.10.6 Abstract The present review describes the current status of synthetic five and six-membered cyclic peroxides such as 1,2-dioxolanes, 1,2,4-trioxolanes (ozonides), 1,2-dioxanes, 1,2-dioxenes, 1,2,4-trioxanes, and 1,2,4,5-tetraoxanes. The literature from 2000 onwards is surveyed to provide an update
, and antitumor agents.
Keywords: cyclic peroxides; 1,2-dioxanes; 1,2-dioxenes; 1,2-dioxolanes; ozonides; 1,2,4,5-tetraoxanes; 1,2,4-trioxanes; 1,2,4-trioxolanes; Introduction
Approaches to the synthesis of five and six-membered cyclic peroxides, such as 1,2-dioxolanes I, 1,2,4-trioxolanes (ozonides
) II, 1,2-dioxanes III, 1,2-dioxenes IV, 1,2,4-trioxanes V, and 1,2,4,5-tetraoxanes VI, published from 2000 to present are reviewed. These compounds are widely used in synthetic and medicinal chemistry (Figure 1).
In the last decade, two reviews on this rapidly progressing field were published by