Beilstein J. Org. Chem.2015,11, 1235–1240, doi:10.3762/bjoc.11.137
]quinazoline; microwave; naphthoquinone; 1,3-quinazoline; 1,3,5-triazinane; Introduction
Quinones represent a diverse family of naturally occurring secondary metabolites [1][2][3]. Interest in these substances has intensified in recent years due to their pharmacological importance [4]. Heterocycle-fused
-substituted benzyl groups. The 1,3,5-triazinane rings of 18 (molecules A and B) adopt a chair conformation, with Cremer–Pople puckering parameters q2 and Φ2 of 0.023(9) Å and 323.0(20)º, respectively, for molecule A, and q2 and Φ2 of 0.016(3) Å and 2.0(25)º, respectively, for molecule B.
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Graphical Abstract
Figure 1:
General template for heterocycle-fused 1,4-naphthoquinones.