Beilstein J. Org. Chem.2010,6, No. 11, doi:10.3762/bjoc.6.11
Diels–Alder reactions involving 1-oxa-1,3-butadienes.
Keywords: β-halo aldehydes; hetero Diels–Alder reaction; 1-oxa-1,3-butadiene; pyrido[2,3-d]pyrimidines; uracil; Introduction
The importance of uracil and its annulated derivatives is well recognized by synthetic as well as biological chemists [1][2
reactions involving 1-oxa-1,3-butadiene. This reaction, which can also be investigated for the synthesis of many other heyterocyclic compounds of biological importance, is a valuable addition to the chemistry of uracils.
Experimental
All reagents and solvents were of reagent grade and were used without
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Graphical Abstract
Scheme 1:
Stereoselective synthesis of some new complex annulated pyrido[2,3-d]pyrimidines by intramolecular ...