Beilstein J. Org. Chem.2011,7, 410–420, doi:10.3762/bjoc.7.53
Ryuji Hayashi John B. Feltenberger Andrew G. Lohse Mary C. Walton Richard P. Hsung Department of Chemistry and Division of Pharmaceutical Sciences, University of Wisconsin, Madison, WI 53705 10.3762/bjoc.7.53 Abstract Preparations of de novo acyclic 2-amido-dienes and 3-amido-trienes through 1,3
-configuration. In addition, 6π-electron electrocyclic ring-closure could be carried out with 3-amido-trienes to afford cyclic 2-amido-dienes, and such electrocyclic ring-closure could be rendered in tandem with the 1,3-hydrogen shift.
Keywords: allenamides; 2-amido-dienes; 3-amido-trienes; electrocyclic ring
][64] (for examples see [65][66][67][68][69][70][71][72]), herein, we report details of an efficient entry to synthetically rare 2-amido-dienes [73][74][75][76][77] via a regio- and stereoselective 1,3-hydrogen shift of allenamides.
Results and Discussion
As part of our initial screening efforts, both