Synthesis and characterization of new diiodocoumarin derivatives with promising antimicrobial activities

• Hany M. Mohamed,
• Ashraf H. F. Abd EL-Wahab,
• Ahmed M. EL-Agrody,
• Ahmed H. Bedair,
• Fathy A. Eid,
• Mostafa M. Khafagy and
• Kamal A. Abd-EL-Rehem

Beilstein J. Org. Chem. 2011, 7, 1688–1696, doi:10.3762/bjoc.7.199

• diiodocoumarin derivatives bearing side chains with different structures, as such derivatives could possess interesting and useful biological properties. Results and Discussion Interaction of 3,5-diiodosalicylaldehyde with diethyl malonate according to the literature procedure [14][15] afforded ethyl 6,8

• Shimadzu GMMS-QP-1000 EX mass spectrometer at 70 eV. The elemental analyses were performed at the Microanalytical Center, Cairo University, Cairo (Egypt). Ethyl 6,8-diiodocoumarin-3-carboxylate (1). Ethyl 6,8-diiodocoumarin-3-carboxylate (1) was prepared by the interaction of 3,5-diiodosalicylaldehyde with

• ethyl 4-oxo-2,6-methano-2-methyl-3,4,5,6-tetrahydro-8,10-diiodobenzo[2,1-g]-2H-1,3-oxazocine-5-carboxylate derivatives 14a,b. All compounds were evaluated for their antimicrobial activity and the compounds 12–14a,b exhibited a pronounced effect on all tested microorganisms. Keywords: antimicrobial; 3,5