New enzymatically polymerized copolymers from 4-tert-butylphenol and 4-ferrocenylphenol and their modification and inclusion complexes with β-cyclodextrin

• Adam Mondrzyk,
• Beate Mondrzik,
• Sabrina Gingter and
• Helmut Ritter

Beilstein J. Org. Chem. 2012, 8, 2118–2123, doi:10.3762/bjoc.8.238

• of a copolymer of 4-tert-butylphenol and 4-ferrocenylphenol by horse radish peroxidase (HRP) in the presence of H2O2 in a 1,4-dioxane/water system is described. Furthermore, polymer-analogous alkylation of the free hydroxy groups and subsequent click reaction with mono-6-azido-6-desoxy-β-cyclodextrin

• (N3-β-CD) was carried out. The formation of inter- and intramolecular inclusion complexes was investigated by DLS measurement. Keywords: copolymer; ß-cyclodextrin; enzymatic polymerization; 4-ferrocenylphenol; polyphenol; 4-tert-butylphenol; horseradish peroxidase; HRP oxidative coupling; inclusion

• functional groups, such as nitrones, double bonds and imides, have been synthetized and investigated in our group [14][15][16][17][18]. There are also several natural phenols such as flavonoides, or isoflavonoides, which were also polymerized successfully [19]. 4-Ferrocenylphenol (2) has been the subject of