Identification of the new prenyltransferase Ubi-297 from marine bacteria and elucidation of its substrate specificity

• Jamshid Amiri Moghaddam,
• Huijuan Guo,
• Karsten Willing,
• Thomas Wichard and
• Christine Beemelmanns

Beilstein J. Org. Chem. 2022, 18, 722–731, doi:10.3762/bjoc.18.72

• conversion of 8-hydroxyquinoline and 1,3-dihydroxynaphthalene were observed. Xanthurenic acid and 4-methylumbelliferone were only farnesylated in negligible amounts, and no product formation was observed for phenols or catechols (Figure 5). Overall, 8-hydroxyquinoline-2-carboxylic acid (8-HQA) appeared to be

Anomeric 1,2,3-triazole-linked sialic acid derivatives show selective inhibition towards a bacterial neuraminidase over a trypanosome trans-sialidase

• Peterson de Andrade,
• Sanaz Ahmadipour and
• Robert A. Field

Beilstein J. Org. Chem. 2022, 18, 208–216, doi:10.3762/bjoc.18.24

• both enzymes (Figure 3A) (and TcTS transferase activity in the presence of an acceptor substrate, such as lactose – Figure 3B) by releasing the fluorophore 4-methylumbelliferone (MU) for detection upon cleavage of the substrate 2'-(4-methylumbelliferyl) α-ᴅ-N-acetylneuraminic acid (MUNANA). Compounds

Anomeric modification of carbohydrates using the Mitsunobu reaction

• Julia Hain,
• Patrick Rollin,
• Werner Klaffke and
• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2018, 14, 1619–1636, doi:10.3762/bjoc.14.138

• Roussel developed a Mitsunobu process to connect noviose with a broad range of 7-hydroxycoumarins [57]. Similarly, Imamura and colleagues used 4-methylumbelliferone (79) as acidic reaction partner in a Mitsunobu glycosylation with a reducing galabioside 78 (Scheme 13) [22]. Advantage was taken of the

Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores

• Mathieu L. Lepage,
• Antoine Mirloup,
• Manon Ripoll,
• Fabien Stauffert,
• Anne Bodlenner,
• Raymond Ziessel and
• Philippe Compain

Beilstein J. Org. Chem. 2015, 11, 659–667, doi:10.3762/bjoc.11.74

• ; fluorescent probes; iminosugars; 4-methylumbelliferone; multivalency; pyrene; Introduction Since the isolation in the 1970’s of 1-deoxynojirimycin (DNJ) from natural sources and the finding of its biological activity as an α-glucosidase inhibitor, thousands of sugar mimetics with a nitrogen atom replacing

• buffer conditions were chosen to be as close as possible to the conditions used for β-glucocerebrosidase activation assays (Gaucher disease) which are based on a fluorescent leaving group (4-methylumbelliferone) allowing fluorescence recording after reaction quenching at pH 10.7 [64]. The BODIPY-based

• diverse analytes and in relevant biosensing and bioimaging applications [73]. One critical aspect for the evaluation of biological activities using fluorescent dyes (e.g., the deprotonated form of 4-methylumbelliferone) [74] is to determine their spectroscopic features in different environments (local pH