Indolizines and pyrrolo[1,2-c]pyrimidines decorated with a pyrimidine and a pyridine unit respectively

• Marcel Mirel Popa,
• Emilian Georgescu,
• Mino R. Caira,
• Florentina Georgescu,
• Constantin Draghici,
• Raluca Stan,
• Calin Deleanu and
• Florea Dumitrascu

Beilstein J. Org. Chem. 2015, 11, 1079–1088, doi:10.3762/bjoc.11.121

• structures of two of the starting materials, 4-(2-pyridyl)pyrimidine and 4-(4-pyridyl)pyrimidine, are also reported. Keywords: indolizine; nitrogen heterocycles; N-ylide; 4-pyridylpyrimidine; pyrrolo[1,2-c]pyrimidine; Introduction Two heteroarenes linked through a single bond [1] proved to be versatile

• pyrimidine. Herein, we report the efficient synthesis of small libraries of structurally diverse pyrrolo-fused heterocycles starting from the 4-pyridylpyrimidine isomers via 1,3-dipolar cycloaddition of corresponding N-ylides with several activated alkynes. The biologic and luminescent properties of newly

• synthesized 3-pyridylpyrrolo[1,2-c]pyrimidine and 7-pyrimidinylindolizine derivatives are under investigation. Results and Discussion Our purpose was to obtain new hetarylpyridines and hetarylpyrimidines. Thus, starting from the 4-pyridylpyrimidine isomers 6–8 (Figure 2) we have obtained new pyrrolo[1,2-c