Hoveyda–Grubbs catalysts with an N→Ru coordinate bond in a six-membered ring. Synthesis of stable, industrially scalable, highly efficient ruthenium metathesis catalysts and 2-vinylbenzylamine ligands as their precursors

• Kirill B. Polyanskii,
• Kseniia A. Alekseeva,
• Pavel V. Raspertov,
• Pavel A. Kumandin,
• Eugeniya V. Nikitina,
• Atash V. Gurbanov and
• Fedor I. Zubkov

Beilstein J. Org. Chem. 2019, 15, 769–779, doi:10.3762/bjoc.15.73

• , ring-opening metathesis polymerization – ROMP and acyclic diene metathesis – ADMET. This motivates the investigations into the development of new, efficient, stable, and highly selective catalytic systems based on ruthenium complexes. However, in reality, a limited set of commercially available

Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists

• Constantinos G. Neochoritis,
• Maryam Kazemi Miraki,
• Eman M. M. Abdelraheem,
• Ewa Surmiak,
• Tryfon Zarganes-Tzitzikas,
• Beata Łabuzek,
• Tad A. Holak and
• Alexander Dömling

Beilstein J. Org. Chem. 2019, 15, 513–520, doi:10.3762/bjoc.15.45

• -pot procedure with one purification step), much better yields, no need of expensive catalysts as in ring-closing metathesis (RCM) reaction and higher complexity/diversity on the macrocyclic ring, e.g., insertion of heteroatoms that could improve the ADMET properties (Scheme 1) [4]. Results and

Aqueous olefin metathesis: recent developments and applications

• Valerio Sabatino and
• Thomas R. Ward

Beilstein J. Org. Chem. 2019, 15, 445–468, doi:10.3762/bjoc.15.39

• metathesis (ADMET), ring-closing metathesis (RCM), ring-opening metathesis (ROM), and cross-metathesis (CM). Catalytic cycle for metathesis proposed by Chauvin. First aqueous ROMP reactions catalyzed by ruthenium(III) salts. Degradation pathway of first generation Grubbs catalyst (G-I) in methanol. Synthesis

Application of olefin metathesis in the synthesis of functionalized polyhedral oligomeric silsesquioxanes (POSS) and POSS-containing polymeric materials

• Patrycja Żak and
• Cezary Pietraszuk

Beilstein J. Org. Chem. 2019, 15, 310–332, doi:10.3762/bjoc.15.28

• silsesquioxanes (POSS) and POSS-containing polymeric materials. Three types of processes, i.e., cross metathesis (CM) of vinyl-substituted POSS with terminal olefins, acyclic diene metathesis (ADMET) copolymerization of divinyl-substituted POSS with α,ω-dienes and ring-opening metathesis polymerization (ROMP) of

• metathesis in chemistry of unsaturated derivatives of POSS is limited to three types of processes, i.e., cross metathesis (CM) of vinyl-substituted POSS with terminal olefins, acyclic diene metathesis (ADMET) copolymerization of divinyl-substituted POSS with α,ω-dienes and ring-opening metathesis

• the application of ADMET in the synthesis of oligomers or polymers containing a POSS unit in the main chain. Marciniec disclosed ADMET copolymerization of DDSQ-2SiVi with dienes in the stereoselective synthesis of a new class of vinylene–arylene copolymers containing double-decker silsesquioxanes in

Olefin metathesis in multiblock copolymer synthesis

• Maria L. Gringolts,
• Yulia I. Denisova,
• Eugene Sh. Finkelshtein and
• Yaroslav V. Kudryavtsev

Beilstein J. Org. Chem. 2019, 15, 218–235, doi:10.3762/bjoc.15.21

• . Keywords: ADMET; macromolecular cross metathesis; multiblock copolymers; olefin metathesis; ROMP; Introduction Nowadays, olefin metathesis has become a well-established field of organic and polymer chemistry. The discovery of metallocarbene initiators that are capable of catalyzing metathesis

• multiple click reactions of the diazido-telechelic PBD with a dialkynyl-containing azobenzene chromophore. The newly formed triazole moieties can tune and improve the photoresponsive properties of PBD. α,ω-Functional telechelic polymers also can be synthesized by acyclic diene metathesis (ADMET

• ) polymerization. This approach was implemented for the preparation of fluorene-containing multiblock copolymers [62][63]. Poly(9,9-di-n-octylfluorene-2,7-vinylene, PFV) obtained by ADMET polymerization of 2,7-divinyl-9,9-di-n-octylfluorene in the presence of Gr2 under reduced pressure (Scheme 4), possessed

The reductive decyanation reaction: an overview and recent developments

• Jean-Marc R. Mattalia

Beilstein J. Org. Chem. 2017, 13, 267–284, doi:10.3762/bjoc.13.30

• . Rojas et al. proposed a convenient two-step pathway for the preparation of alkyl α,ω-dienes 3. These dienes are well-known precursors in ring-closing metathesis (RCM) and acyclic diene metathesis (ADMET) chemistry [32]. They first reported the quantitative α-alkylation of primary nitriles 1 [33]. In a

Recent advances in metathesis-derived polymers containing transition metals in the side chain

• Ileana Dragutan,
• Valerian Dragutan,
• Bogdan C. Simionescu,
• Albert Demonceau and
• Helmut Fischer

Beilstein J. Org. Chem. 2015, 11, 2747–2762, doi:10.3762/bjoc.11.296

• ) polymerization [15][16], living ionic polymerizations, specifically ring-opening polymerization (ROP) [17], as well as migration insertion polymerization (MIP) [18], acyclic diene metathesis polymerization (ADMET) [19][20] and ring-opening metathesis polymerization (ROMP) [21][22][23][24][25][26][27]. These

About the activity and selectivity of less well-known metathesis catalysts during ADMET polymerizations

• Hatice Mutlu,
• Lucas Montero de Espinosa,
• Oĝuz Türünç and
• Michael A. R. Meier

Beilstein J. Org. Chem. 2010, 6, 1149–1158, doi:10.3762/bjoc.6.131

• , Department of Colloid Chemistry, Potsdam, Germany 10.3762/bjoc.6.131 Abstract We report on the catalytic activity of commercially available Ru-indenylidene and “boomerang” complexes C1, C2 and C3 in acyclic diene metathesis (ADMET) polymerization of a fully renewable α,ω-diene. A high activity of these

• ADMET polymerizations were studied in detail. The isomerization reactions were investigated by degradation of the prepared polyesters via transesterification with methanol, yielding diesters. These diesters, representing the repeat units of the polyesters, were then quantified by GC-MS. Keywords: ADMET

• the isomerization of a number of allylic ethers and long chain aliphatic alkenes during RCM and cross metathesis [21]. In the context of ADMET, isomerization of a terminal to an internal olefin, followed by a productive metathesis step with a terminal olefin, would liberate an α-olefin, such as

Synthesis and crossover reaction of TEMPO containing block copolymer via ROMP

• Olubummo Adekunle,
• Susanne Tanner and
• Wolfgang H. Binder

Beilstein J. Org. Chem. 2010, 6, No. 59, doi:10.3762/bjoc.6.59

• achieved extensively via living polymerization methods. Thus, besides acyclic diene metathesis polymerization (ADMET) [2], ring opening metathesis polymerization (ROMP) [3][4][5] is another type of olefin metathesis polymerization that can be used for the synthesis of block copolymers. Early examples of