Radical-mediated dehydrative preparation of cyclic imides using (NH₄)₂S₂O₈–DMSO: application to the synthesis of vernakalant

• Dnyaneshwar N. Garad,
• Subhash D. Tanpure and
• Santosh B. Mhaske

Beilstein J. Org. Chem. 2015, 11, 1008–1016, doi:10.3762/bjoc.11.113

• Dnyaneshwar N. Garad Subhash D. Tanpure Santosh B. Mhaske CSIR-National Chemical Laboratory, Division of Organic Chemistry, Pune 411 008, India 10.3762/bjoc.11.113 Abstract Ammonium persulfate–dimethyl sulfoxide (APS–DMSO) has been developed as an efficient and new dehydrating reagent for a

• for a practical synthesis of vernakalant. Keywords: APS-DMSO; imides; practical synthesis; radical-mediated; vernakalant; Introduction Cyclic imides are privileged pharmacophores and important building blocks for the synthesis of natural products, drugs, agrochemicals, advanced materials and

• a convenient one-pot process for the preparation of structurally diverse cyclic imides starting from readily available primary amines and cyclic anhydrides using APS–DMSO as an efficient and novel dehydrating reagent and its application to a drug synthesis. The scope of the developed protocol was