Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

• Matthew B. Plutschack,
• D. Tyler McQuade,
• Giulio Valenti and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2013, 9, 2022–2027, doi:10.3762/bjoc.9.238

• available from Thales). With a flow rate of 1 mL/min at 100 bar and 70 °C using a 10% Pd/C CatCart, a throughput of 8 mg/min was achieved. The crude reaction solution was pure by NMR and was used without further purification. As shown in Table 1, the hydrogenolysis represents a bottleneck in the synthesis

Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

• Marian C. Bryan,
• David Wernick,
• Christopher D. Hein,
• James V. Petersen,
• John W. Eschelbach and
• Elizabeth M. Doherty

Beilstein J. Org. Chem. 2011, 7, 1141–1149, doi:10.3762/bjoc.7.132

• run-to-run reproducibility of the H-Cube® reactor for screening and reaction optimization is discussed. Keywords: catalyst leaching; CatCart®; H-Cube®; packed bed flow hydrogenation; Introduction The potential advantages of heterogeneous catalytic flow hydrogenation over traditional batch reactor

• a convenient bench-top hydrogen flow reactor, the H-Cube®, designed for smaller-scale use in academic and drug discovery labs [6]. The reactor features a built-in hydrogen generator that functions by the electrolysis of water. Disposable pre-packed catalyst cartridges (CatCart®) are also available

• ]. Subsequently, ThalesNano commercialized the system developed by Ley and Ladlow. More recently, ThalesNano has introduced a CatCart Changer® (CCC) attachment with six CatCart® port positions and a column switcher to increase throughput and facilitate screening through multiple catalysts. These ThalesNano H-Cube