Natural products in the predatory defence of the filamentous fungal pathogen Aspergillus fumigatus

• Jana M. Boysen,
• Nauman Saeed and
• Falk Hillmann

Beilstein J. Org. Chem. 2021, 17, 1814–1827, doi:10.3762/bjoc.17.124

• A. fumigatus suggests a role of gliotoxin in natural microenvironments. In vitro studies have also revealed the amoebicidal activities of gliotoxin on its natural co-inhabitant Dictyostelium discoideum [82]. However, these pathogenic activities sometimes prove to be beneficial for other co-habitants

Emission and biosynthesis of volatile terpenoids from the plasmodial slime mold Physarum polycephalum

• Xinlu Chen,
• Tobias G. Köllner,
• Wangdan Xiong,
• Guo Wei and
• Feng Chen

Beilstein J. Org. Chem. 2019, 15, 2872–2880, doi:10.3762/bjoc.15.281

• genes. TPS genes were found in 6 species of sequenced amoeba, including Dictyostelium discoideum, D. purpureum, Cavenderia fasciculata (formerly D. fasciculatum), Tieghemostelium lacteum (formerly D. lacteum), Heterostelium album (formerly Polysphondylium pallidum), and Actyostelium subglobosum [14

18-Hydroxydolabella-3,7-diene synthase – a diterpene synthase from Chitinophaga pinensis

• Jeroen S. Dickschat,
• Jan Rinkel,
• Patrick Rabe,
• Arman Beyraghdar Kashkooli and
• Harro J. Bouwmeester

Beilstein J. Org. Chem. 2017, 13, 1770–1780, doi:10.3762/bjoc.13.171

• ]. Recently, the first terpene synthases were reported from a eukaryotic soil microorganism, the social amoeba Dictyostelium discoideum [4][5]. With respect to bacterial enzymes, many terpene synthases have been identified and their products have been structurally characterised (reviewed in [6], following

The chemistry and biology of mycolactones

• Matthias Gehringer and
• Karl-Heinz Altmann

Beilstein J. Org. Chem. 2017, 13, 1596–1660, doi:10.3762/bjoc.13.159

Versatile synthesis of the signaling peptide glorin

• Robert Barnett,
• Daniel Raszkowski,
• Thomas Winckler and
• Pierre Stallforth

Beilstein J. Org. Chem. 2017, 13, 247–250, doi:10.3762/bjoc.13.27

• as well as in the design of chemical probes to dissect glorin-mediated signaling pathways. Keywords: Dictyostelium; glorin; multicellularity; Polysphondylium; signaling molecules; social amoebae; Introduction The emergence of multicellularity from unicellular ancestors is considered a major

• numerous species of social amoebae such as Polysphondylium pallidum, Dictyostelium fasciculatum [11], and D. caveatum [12], amongst others respond chemotactically to glorin (1), the acrasin has only been isolated from P. violaceum [13]. Despite its crucial role in the initiation of multicellularity, little

• glorinamide 2 were assayed by their ability to elevate the expression of the glorin-induced gene PPL_09347 in the social amoeba P. pallidum, as previously determined [11]. We chose the gene PPL_09347, which encodes the Dictyostelium discoideum ortholog of profilin I, an actin binding protein required for the