Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites

• Antonio Dávila-Céspedes,
• Peter Hufendiek,
• Max Crüsemann,
• Till F. Schäberle and
• Gabriele M. König

Beilstein J. Org. Chem. 2016, 12, 969–984, doi:10.3762/bjoc.12.96

• metabolites. A most unusual structural type is represented by salimabromide from Enhygromyxa salina. In silico analyses were carried out on the available genome sequences of four bacterial members of the Nannocystineae, revealing the biosynthetic potential of these bacteria. Keywords: Enhygromyxa; genome

• ] discovered the first strictly halophilic myxobacteria within the suborder Nannocystineae, namely Enhygromyxa, Haliangium, and Plesiocystis, which strictly require sea-like salinity conditions in order to grow. Whether the adaptation to the marine environment was acquired independently several times, or if

• osmoprotective strategies of Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1 revealed that both closely related strains rely on organic osmolytes. For instance, E. salina SWB007 biosynthesizes the osmolytes betaine, ectoine, and especially hydroxyectoine under high salt concentrations. In contrast, P