Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs

• Fabrizio Chiodo,
• Marco Marradi,
• Javier Calvo,
• Eloisa Yuste and
• Soledad Penadés

Beilstein J. Org. Chem. 2014, 10, 1339–1346, doi:10.3762/bjoc.10.136

• therapeutic approach for the treatment of HIV infection is based on the highly active antiretroviral therapy (HAART), a cocktail of antiretroviral drugs. Notwithstanding HAART has shown different drawbacks like toxic side effects and the emergence of viral multidrug resistance. Nanotechnology offers new tools

• glyconanoparticles as a new multifunctional drug-delivery system in the therapy against HIV. Keywords: drug-delivery system; gold glyconanoparticles; HAART; HIV; multivalent glycosystems; reverse transcriptase inhibitors; Introduction Acquired immune deficiency syndrome (AIDS), caused by human immunodeficiency

• preventions, the strategies used to inhibit viral replication in human CD4+ T cells consist in the highly active antiretroviral therapy (HAART) [3] and the design of a vaccine that should protect people among all the different HIV strains [4][5]. Although great results have been obtained by the use of the