Beilstein J. Org. Chem.2013,9, 2925–2933, doi:10.3762/bjoc.9.329
, Australia 10.3762/bjoc.9.329 Abstract A small sample of (−)-(5R,6Z)-dendrolasin-5-acetate, which was fully characterized by 2D NMR studies, was isolated from the nudibranch Hypselodoris jacksoni, along with the sesquiterpenes (+)-agassizin, (−)-furodysinin, (−)-euryfuran, (−)-dehydroherbadysidolide and
obtained by preparative enantioselective HPLC.
Keywords: enantioselective HPLC; E/Z-isomers; Hypselodoris; natural products; nudibranch; sesquiterpene; Introduction
Marine organisms have been proven a prolific source of natural products that potentially can be used as lead compounds or which have
(either directly or as a derivative) that have been approved for FDA use as a drug or are in clinical trials were first isolated from molluscs. For some of these bioactives, the actual biosynthetic source is a microorganism [6].
Within the Nudibranchia, the genus Hypselodoris is generally characterized by
PDF
Graphical Abstract
Figure 1:
(−)-(5R,6Z)-Dendrolasin-5-acetate (1), its 6E derivative and naturally occuring dentrolasin (3).