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Search for "Photorhabdus" in Full Text gives 7 result(s) in Beilstein Journal of Organic Chemistry.
Fabclavine diversity in Xenorhabdus bacteria
Beilstein J. Org. Chem. 2020, 16, 956–965, doi:10.3762/bjoc.16.84
- for bioactive compounds are required, such as the bacterial genera Xenorhabdus or Photorhabdus. In these strains, fabclavines are widely distributed SMs with a broad-spectrum bioactivity. Fabclavines are hybrid SMs derived from nonribosomal peptide synthetases (NRPS), polyunsaturated fatty acid (PUFA
- ), and polyketide synthases (PKS). Selected Xenorhabdus and Photorhabdus mutant strains were generated applying a chemically inducible promoter in front of the suggested fabclavine (fcl) biosynthesis gene cluster (BGC), followed by the analysis of the occurring fabclavines. Subsequently, known and
- actinomycetes and myxobacteria, the genera Photorhabdus and Xenorhabdus are promising sources to discover new SMs since up to 6.5% of their overall genome sequence are associated with SM biosynthesis [5][6]. This includes antimicrobials like isopropylstilbene, xenocoumacins, amicoumacin, and several other SMs
Glycoscience@Synchrotron: Synchrotron radiation applied to structural glycoscience
Beilstein J. Org. Chem. 2017, 13, 1145–1167, doi:10.3762/bjoc.13.114
Solid-phase enrichment and analysis of electrophilic natural products
Beilstein J. Org. Chem. 2017, 13, 405–409, doi:10.3762/bjoc.13.43
- entomopathogenic Photorhabdus bacteria. Keywords: azides; click chemistry; enrichment; electrophilic natural products; epoxides; glidobactin; Photorhabdus; stilbenes; Introduction Microorganisms are a major source for novel natural products and the subsequent development of new drugs for all kinds of
- for the detection of electrophilic natural products using azide as the nucleophile. Indeed, we could detect epoxystilbene 1 and three glidobactins from different Photorhabdus strains and some of these compounds are produced in such low amounts that they are not detectable in standard crude extracts
- 1. Encouraged by these results and especially the high sensitivity of the method, the azidation was performed with XAD extracts of three additional Photorhabdus strains (Photorhabdus PB45.5, Photorhabdus PB 68.1 and Photorhabdus temperata subsp. thracensis DSM 15199). Here, an even lower amount of 3
Biosynthesis of α-pyrones
Beilstein J. Org. Chem. 2016, 12, 571–588, doi:10.3762/bjoc.12.56
- ], and recently it was reported that so called photopyrones (8–15) act as signaling molecules in the cell–cell communication system of the bacterium Photorhabdus luminescens (Figure 1) [14]. Since the biological activities of α-pyrones are very diverse, these compounds are in the focus of synthetic
- function for α-pyrones within bacteria was discovered. The so called photopyrones (8–15, Figure 1) represent extracellular signals involved in cell–cell communication [14]. Photorhabdus luminescens, an entomopathogenic bacterium species, excretes these molecules, and binding of the latter to the respective
- receptor, i.e., the PluR protein, leads to the activation of the Photorhabdus clumping factor (PCF) operon (pcfABCDEF). The phenotypic change observed due to PCF expression was cell clumping, which in turn contributed to insect toxicity [14]. Structurally related are the pseudopyronines A (55), B (56), and
Recent highlights in biosynthesis research using stable isotopes
Beilstein J. Org. Chem. 2015, 11, 2493–2508, doi:10.3762/bjoc.11.271
- to different cyclic peptides from Photorhabdus and Xenorhabdus species [42] and for activity testing of heterologously expressed SAM-epimerases from various bacteria [43]. In a follow-up study the recently discovered NRPS product kollosin A (16, Figure 4) was investigated. This pentadecapeptide is
- made by the largest known NRPS that consists of 15 modules and is encoded by a single 49.1 kbp gene found in the entomopathogenic bacterium Photorhabdus luminescens [44]. Despite the non-detectable expression under various fermentation conditions, it was possible to express the machinery using a
A novel and widespread class of ketosynthase is responsible for the head-to-head condensation of two acyl moieties in bacterial pyrone biosynthesis
Beilstein J. Org. Chem. 2015, 11, 1412–1417, doi:10.3762/bjoc.11.152
- , 60438 Frankfurt am Main, Germany 10.3762/bjoc.11.152 Abstract The biosynthesis of photopyrones, novel quorum sensing signals in Photorhabdus, has been studied by heterologous expression of the photopyrone synthase PpyS catalyzing the head-to-head condensation of two acyl moieties. The biochemical
- [5] and selective COX-2 inhibitors [6]. Recently, it was shown that photopyrones (Figure 1) are signaling molecules in a new cell–cell communication system in the entomopathogenic bacterium Photorhabdus luminescens. The system consists of endogenously produced photopyrones as signaling molecules and
- PluR, a LuxR-like receptor [7]. The binding of photopyrones by PluR leads to the expression of the Photorhabdus clumping factor (PCF) operon (pcfABCDEF) that causes clumping of cells and results in insect toxicity [7]. Responsible for the formation of photopyrones is an unusual ketosynthase, named
Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum
Beilstein J. Org. Chem. 2012, 8, 528–533, doi:10.3762/bjoc.8.60
- may be required for different stages of this life cycle, including the symbiotic stage (towards the nematode) or pathogenic stage (towards the insect prey) [1][2][3]. Until three years ago, the natural products extracted from Xenorhabdus and its close neighbour Photorhabdus were only low-molecular
- ], xenematide [8] and the GameXPeptides [9]. Analysis of the genome sequences of the fully sequenced members of Xenorhabdus and Photorhabdus [10][11] has revealed that several additional compounds and especially even much larger compounds await isolation and structure elucidation. Recently, szentiamide (1) has
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