Beilstein J. Org. Chem.2019,15, 2872–2880, doi:10.3762/bjoc.15.281
genes. TPS genes were found in 6 species of sequenced amoeba, including Dictyostelium discoideum, D. purpureum, Cavenderia fasciculata (formerly D. fasciculatum), Tieghemostelium lacteum (formerly D. lacteum), Heterostelium album (formerly Polysphondylium pallidum), and Actyostelium subglobosum [14
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Graphical Abstract
Figure 1:
Plasmodia of P. polycephalum emit a mixture of volatiles predominated by terpenoids. A) GC chromato...
Beilstein J. Org. Chem.2017,13, 247–250, doi:10.3762/bjoc.13.27
activate glorin-induced genes in the social amoeba Polysphondylium pallidum was evaluated by quantitative reverse transcription PCR, whereby both compounds showed bioactivity comparable to a glorin standard. This synthetic route will be useful in conducting detailed structure–activity relationship studies
as well as in the design of chemical probes to dissect glorin-mediated signaling pathways.
Keywords: Dictyostelium; glorin; multicellularity; Polysphondylium; signaling molecules; social amoebae; Introduction
The emergence of multicellularity from unicellular ancestors is considered a major
numerous species of social amoebae such as Polysphondylium pallidum, Dictyostelium fasciculatum [11], and D. caveatum [12], amongst others respond chemotactically to glorin (1), the acrasin has only been isolated from P. violaceum [13]. Despite its crucial role in the initiation of multicellularity, little