Beilstein J. Org. Chem.2011,7, 179–197, doi:10.3762/bjoc.7.25
involve the reactions of β-ketonitriles, malononitrile, alkylidenemalononitriles and their derivatives with hydrazines, as well as some novel miscellaneous methods.
Keywords: alkylidenemalononitriles; 5-aminopyrazoles; hydrazines; β-ketonitriles; malononitriles; Review
The 5-aminopyrazole system
].
Synthesis of 5-amino-1-heteroaryl-3-methyl/aryl-4-cyanopyrazoles 102 has been carried out by us by treating various heteroarylhydrazines with alkylidenemalononitriles 101 in refluxing ethanol (Scheme 28) [70]. The starting material 101a (R = C2H5, R1 = CH3) was obtained by the reaction of malononitrile with
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Graphical Abstract
Figure 1:
Pharmacologically active 5-aminopyrazoles.