Beilstein J. Org. Chem.2013,9, 557–576, doi:10.3762/bjoc.9.61
processes.
Keywords: amidyls; iminyls; radical allylation; radical vinylation; xanthate transfer; Introduction
Natural products exhibit an astonishing diversity of molecular architectures and structural complexity. This has spurred the development of numerous synthetic strategies for the rapid assembly of
creation of C–N bonds and for the synthesis of alkaloids is enormous [6]. One possible explanation is the lack, hitherto, of mild yet general methods for the generation of the various types of nitrogen radicals: aminyls, aminiums, iminyls, amidyls, carbamyls, ureidyls, etc.
We discovered some years ago
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Graphical Abstract
Scheme 1:
Key radical step in the total synthesis of (–)-dendrobine.